SMAD4 NM_005359.6(SMAD4):c.1082G>A (p.Arg361His)

CI-VAR-00006579Explore in graph →p.Arg361HisNM_005359.6:c.1082G>AClinVar 24832 rs377767347

Curated evidence

Evidence by cancer (0 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

Data not yet available

No curated evidence item references this variant yet.

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
24832	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	Juvenile polyposis syndrome; Myhre syndrome; Carcinoma of pancreas; Generalized juvenile polyposis/juvenile polyposis coli; Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome; Familial thoracic aortic aneurysm and aortic dissection; Hereditary cancer-predisposing syndrome; Neoplasm; Colorectal cancer; SMAD4-related disorder	germline/somatic	9	Nov 03, 2025	clinvar