SMAD4 H132Y

CI-VAR-00001896Explore in graph →CIViC 3803

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
SMAD4 H132Y	(functional)	Functional	D	Supports Dominant Negative	3	submitted	EID10275 Exome sequencing of a panel of HNSCC-derived cell lines identified three lines with SMAD4 alterations, two with truncating mutations and one (UM-SCC-2) with the missense mutation H132Y. H132Y was pred… (full text at CIViC) PMID 25275298 · Martin et al., 2014 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.