SMAD4 D351H

CI-VAR-00000482Explore in graph →CIViC 2852

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Unmapped disease1unmapped disease
SMAD4 D351H	(functional)	Functional	D	Supports Loss Of Function	3	submitted	EID7681 Constructs containing SMAD4 mutations were introduced into MDA-MB468, a breast adenocarcinoma cell line with homozygous loss of SMAD4 and insensitivity to TGF-beta. A TGF-beta responsive luciferase re… (full text at CIViC) PMID 14647410 · Kuang et al., 2004 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.