SMAD4 Loss-of-function

CI-VAR-00002535Explore in graph →CIViC 2415

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm1
SMAD4 Loss-of-function	Lysine	Predictive	B	Supports Resistance	4	submitted	EID6448 In this study, the goal was to find the predictive effect of lysine treatment with the under expression of SMAD4 for patients with colorectal cancer(CRC). The study used only female patients as it was… (full text at CIViC) PMID 27875625 · Ganesh et al., 2017 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.