PIK3CA

← targets

Samotolisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Pilaralisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Pictilisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Omipalisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Izorlisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Inavolisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Dactolisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Copanlisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Buparlisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Apitolisibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Alpelisibsmall_molecule

—

INHIBITOR

—

Curated

Malignant Neoplasm,Solid Neoplasm,Malignant Breast Neoplasm+2

PIK3CA has variant …HAS_VARIANTderived15 of 788show all (up to 200)
→ has variant	Mutationother 44 accepted CIViC evidence items	—	—	Malignant Neoplasm,Solid Neoplasm,Malignant Breast Neoplasm+2	44	Curated	civic	graph →
→ has variant	H1047RSNV 30 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Head and Neck Neoplasm,Head and Neck Squamous Cell Carcinoma+2	30	Curated	civic	graph →
→ has variant	E545KSNV 29 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Breast Neoplasm,Melanoma+2	29	Curated	civic	graph →
→ has variant	E542KSNV 15 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Head and Neck Squamous Cell Carcinoma,Malignant Thyroid Gland Neoplasm+2	15	Curated	civic	graph →
→ has variant	K111NSNV 12 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,HER2-Positive Breast Carcinoma	12	Curated	civic	graph →
→ has variant	H1047LSNV 7 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Breast Tubular Carcinoma,Malignant Colorectal Neoplasm	7	Curated	civic	graph →
→ has variant	C420RSNV 6 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Colorectal Neoplasm,HER2-Positive Breast Carcinoma	6	Curated	civic	graph →
→ has variant	Exon 10 Mutation 6 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Colorectal Neoplasm,Rectal Carcinoma	6	Curated	civic	graph →
→ has variant	Exon 21 Mutation 6 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Colorectal Neoplasm,Rectal Carcinoma	6	Curated	civic	graph →
→ has variant	Amplificationamplification 5 accepted CIViC evidence items	—	—	Gastric Carcinoma,Head and Neck Squamous Cell Carcinoma,Ovarian Carcinoma+2	5	Curated	civic	graph →
→ has variant	Overexpressionexpression 5 accepted CIViC evidence items	—	—	Melanoma,HER2-Positive Breast Carcinoma	5	Curated	civic	graph →
→ has variant	E545GSNV 3 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Melanoma	3	Curated	civic	graph →
→ has variant	R88QSNV 3 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Colorectal Neoplasm	3	Curated	civic	graph →
→ has variant	E545ASNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ has variant	E545DSNV 2 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	2	Curated	civic	graph →

PIK3CA has variant …HAS_VARIANTderived15 of 788show all (up to 200)

→ has variant

Mutationother

44 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Malignant Head and Neck Neoplasm,Head and Neck Squamous Cell Carcinoma+2

→ has variant

H1047RSNV

30 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Malignant Breast Neoplasm,Melanoma+2

→ has variant

E545KSNV

29 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Head and Neck Squamous Cell Carcinoma,Malignant Thyroid Gland Neoplasm+2

→ has variant

E542KSNV

15 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,HER2-Positive Breast Carcinoma

→ has variant

K111NSNV

12 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Breast Tubular Carcinoma,Malignant Colorectal Neoplasm

→ has variant

H1047LSNV

7 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Malignant Colorectal Neoplasm,HER2-Positive Breast Carcinoma

→ has variant

C420RSNV

6 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Malignant Colorectal Neoplasm,Rectal Carcinoma

→ has variant

Exon 10 Mutation

6 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Malignant Colorectal Neoplasm,Rectal Carcinoma

→ has variant

Exon 21 Mutation

6 accepted CIViC evidence items

—

Curated

Gastric Carcinoma,Head and Neck Squamous Cell Carcinoma,Ovarian Carcinoma+2

→ has variant

Amplificationamplification

5 accepted CIViC evidence items

—

Curated

Melanoma,HER2-Positive Breast Carcinoma

→ has variant

Overexpressionexpression

5 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Melanoma

→ has variant

E545GSNV

3 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm,Malignant Colorectal Neoplasm

→ has variant

R88QSNV

3 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm

→ has variant

E545ASNV

2 accepted CIViC evidence items

—

Curated

Malignant Breast Neoplasm

→ has variant

E545DSNV

2 accepted CIViC evidence items

—

Curated

Lung Squamous Cell Carcinoma

PIK3CA altered in cohorts of …ALTERED_INderived27 of 27show fewer
→ altered in cohorts of	Lung Squamous Cell Carcinoma 442 / 504 cases (88 %) · ssm · TCGA-LUSC · largest of 5 cohorts	—	—	Lung Squamous Cell Carcinoma	5	Observed	gdc	graph →
→ altered in cohorts of	Cervical Carcinoma 248 / 306 cases (81 %) · ssm · TCGA-CESC · largest of 2 cohorts	—	—	Cervical Carcinoma	2	Observed	gdc	graph →
→ altered in cohorts of	Uterine Carcinosarcoma 46 / 57 cases (81 %) · ssm · TCGA-UCS	—	—	Uterine Carcinosarcoma	1	Observed	gdc	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinomasubtype 390 / 528 cases (74 %) · ssm · TCGA-HNSC · largest of 5 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	5	Observed	gdc	graph →
→ altered in cohorts of	Esophageal Carcinoma 130 / 185 cases (70 %) · ssm · TCGA-ESCA	—	—	Esophageal Carcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Endometrial Carcinoma 824 / 1,882 cases (44 %) · ssm · ucec_ancestry_cds_msk_2023 · largest of 11 cohorts	—	—	Endometrial Carcinoma	11	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 105 / 247 cases (43 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 1,401 / 3,879 cases (36 %) · ssm · breast_msk_2025 · largest of 19 cohorts	—	—	Invasive Breast Carcinoma	19	Observed	cbioportal	graph →
→ altered in cohorts of	Uterine Malignant Mixed Mesodermal (Mullerian) Tumor 20 / 57 cases (35 %) · ssm · ucs_tcga · largest of 3 cohorts	—	—	Uterine Malignant Mixed Mesodermal (Mullerian) Tumor	3	Observed	cbioportal	graph →
→ altered in cohorts of	Malignant Breast Neoplasmcancer_family 52 / 174 cases (30 %) · ssm · CMI-MBC	—	—	Malignant Breast Neoplasm	1	Observed	gdc	graph →
→ altered in cohorts of	Colon Adenocarcinoma 127 / 429 cases (30 %) · ssm · coad_tcga_gdc · largest of 4 cohorts	—	—	Colon Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Cervical Squamous Cell Carcinoma 83 / 291 cases (29 %) · ssm · cesc_tcga_pan_can_atlas_2018 · largest of 3 cohorts	—	—	Cervical Squamous Cell Carcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 103 / 474 cases (22 %) · ssm · blca_msk_tcga_2020 · largest of 14 cohorts	—	—	Bladder Urothelial Carcinoma	14	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 1,486 / 7,237 cases (21 %) · ssm · crc_msk_2026 · largest of 2 cohorts	—	—	Rectal Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 229 / 1,134 cases (20 %) · ssm · crc_msk_2017 · largest of 10 cohorts	—	—	Colorectal Adenocarcinoma	10	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 77 / 518 cases (15 %) · ssm · stes_tcga_pub · largest of 3 cohorts	—	—	Gastroesophageal Junction Adenocarcinoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinomasubtype 65 / 478 cases (14 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Ampulla of Vater Carcinoma 21 / 160 cases (13 %) · ssm · ampca_bcm_2016	—	—	Ampulla of Vater Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinomasubtype 54 / 447 cases (12 %) · ssm · nsclc_tracerx_2017 · largest of 2 cohorts	—	—	Lung Non-Small Cell Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 111 / 1,004 cases (11 %) · ssm · glioma_mskcc_2019 · largest of 11 cohorts	—	—	Diffuse Glioma	11	Observed	cbioportal	graph →
→ altered in cohorts of	Gallbladder Carcinoma 26 / 244 cases (11 %) · ssm · gbc_mskcc_2022	—	—	Gallbladder Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Appendix Adenocarcinoma 26 / 273 cases (9.5 %) · ssm · appendiceal_msk_2022	—	—	Appendix Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinomasubtype 159 / 2,653 cases (6.0 %) · ssm · luad_mskcc_2023_met_organotropism · largest of 5 cohorts	—	—	Lung Adenocarcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 41 / 696 cases (5.9 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Prostate Adenocarcinoma 24 / 424 cases (5.7 %) · ssm · prad_mcspc_mskcc_2020	—	—	Prostate Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Adenoid Cystic Carcinoma 54 / 1,049 cases (5.1 %) · ssm · acc_2019	—	—	Adenoid Cystic Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cholangiocarcinoma 21 / 417 cases (5.0 %) · ssm · chol_icgc_2017	—	—	Cholangiocarcinoma	1	Observed	cbioportal	graph →

PIK3CA altered in cohorts of …ALTERED_INderived27 of 27show fewer

→ altered in cohorts of

442 / 504 cases (88 %) · ssm · TCGA-LUSC · largest of 5 cohorts

—

Lung Squamous Cell Carcinoma

Observed

→ altered in cohorts of

Cervical Carcinoma

248 / 306 cases (81 %) · ssm · TCGA-CESC · largest of 2 cohorts

—

Cervical Carcinoma

Observed

→ altered in cohorts of

Uterine Carcinosarcoma

46 / 57 cases (81 %) · ssm · TCGA-UCS

—

Uterine Carcinosarcoma

Observed

Head and Neck Squamous Cell Carcinoma

→ altered in cohorts of

Head and Neck Squamous Cell Carcinomasubtype

390 / 528 cases (74 %) · ssm · TCGA-HNSC · largest of 5 cohorts

—

Observed

→ altered in cohorts of

Esophageal Carcinoma

130 / 185 cases (70 %) · ssm · TCGA-ESCA

—

Esophageal Carcinoma

Observed

→ altered in cohorts of

Endometrial Carcinoma

824 / 1,882 cases (44 %) · ssm · ucec_ancestry_cds_msk_2023 · largest of 11 cohorts

—

Endometrial Carcinoma

Observed

Endometrial Endometrioid Adenocarcinoma

→ altered in cohorts of

105 / 247 cases (43 %) · ssm · uec_cptac_gdc

—

Endometrial Endometrioid Adenocarcinoma

Observed

Invasive Breast Carcinoma

→ altered in cohorts of

1,401 / 3,879 cases (36 %) · ssm · breast_msk_2025 · largest of 19 cohorts

—

Invasive Breast Carcinoma

Observed

Uterine Malignant Mixed Mesodermal (Mullerian) Tumor

→ altered in cohorts of

20 / 57 cases (35 %) · ssm · ucs_tcga · largest of 3 cohorts

—

Uterine Malignant Mixed Mesodermal (Mullerian) Tumor

Observed

Malignant Breast Neoplasm

→ altered in cohorts of

Malignant Breast Neoplasmcancer_family

52 / 174 cases (30 %) · ssm · CMI-MBC

—

Observed

→ altered in cohorts of

Colon Adenocarcinoma

127 / 429 cases (30 %) · ssm · coad_tcga_gdc · largest of 4 cohorts

—

Colon Adenocarcinoma

Observed

Cervical Squamous Cell Carcinoma

→ altered in cohorts of

83 / 291 cases (29 %) · ssm · cesc_tcga_pan_can_atlas_2018 · largest of 3 cohorts

—

Cervical Squamous Cell Carcinoma

Observed

Bladder Urothelial Carcinoma

→ altered in cohorts of

103 / 474 cases (22 %) · ssm · blca_msk_tcga_2020 · largest of 14 cohorts

—

Bladder Urothelial Carcinoma

Observed

→ altered in cohorts of

Rectal Adenocarcinoma

1,486 / 7,237 cases (21 %) · ssm · crc_msk_2026 · largest of 2 cohorts

—

Rectal Adenocarcinoma

Observed

Colorectal Adenocarcinoma

→ altered in cohorts of

229 / 1,134 cases (20 %) · ssm · crc_msk_2017 · largest of 10 cohorts

—

Colorectal Adenocarcinoma

Observed

Gastroesophageal Junction Adenocarcinoma

→ altered in cohorts of

77 / 518 cases (15 %) · ssm · stes_tcga_pub · largest of 3 cohorts

—

Gastroesophageal Junction Adenocarcinoma

Observed

→ altered in cohorts of

Gastric Adenocarcinomasubtype

65 / 478 cases (14 %) · ssm · stad_tcga · largest of 4 cohorts

—

Gastric Adenocarcinoma

Observed

Ampulla of Vater Carcinoma

→ altered in cohorts of

21 / 160 cases (13 %) · ssm · ampca_bcm_2016

—

Ampulla of Vater Carcinoma

Observed

Lung Non-Small Cell Carcinoma

→ altered in cohorts of

Lung Non-Small Cell Carcinomasubtype

54 / 447 cases (12 %) · ssm · nsclc_tracerx_2017 · largest of 2 cohorts

—

Observed

→ altered in cohorts of

Diffuse Glioma

111 / 1,004 cases (11 %) · ssm · glioma_mskcc_2019 · largest of 11 cohorts

—

Diffuse Glioma

Observed

→ altered in cohorts of

Gallbladder Carcinoma

26 / 244 cases (11 %) · ssm · gbc_mskcc_2022

—

Gallbladder Carcinoma

Observed

→ altered in cohorts of

Appendix Adenocarcinoma

26 / 273 cases (9.5 %) · ssm · appendiceal_msk_2022

—

Appendix Adenocarcinoma

Observed

→ altered in cohorts of

Lung Adenocarcinomasubtype

159 / 2,653 cases (6.0 %) · ssm · luad_mskcc_2023_met_organotropism · largest of 5 cohorts

—

Lung Adenocarcinoma

Observed

→ altered in cohorts of

Cutaneous Melanoma

41 / 696 cases (5.9 %) · ssm · mel_mskimpact_2020

—

Cutaneous Melanoma

Observed

→ altered in cohorts of

Prostate Adenocarcinoma

24 / 424 cases (5.7 %) · ssm · prad_mcspc_mskcc_2020

—

Prostate Adenocarcinoma

Observed

→ altered in cohorts of

Adenoid Cystic Carcinoma

54 / 1,049 cases (5.1 %) · ssm · acc_2019

—

Adenoid Cystic Carcinoma

Observed

→ altered in cohorts of

Cholangiocarcinoma

21 / 417 cases (5.0 %) · ssm · chol_icgc_2017

—

Cholangiocarcinoma

Observed