NTRK2

neurotrophic receptor tyrosine kinase 2

Identifier: CI-GENE-00017360
Entity page: /gene/NTRK2 ↗
Edges: 39

Neighbours: 14 cancers15 variants6 drugs
Drawn: 35 of 35 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
NTRK2 associated with …ASSOCIATED_WITH14 of 14
→ associated with	Solid Neoplasmcancer_family 2 source records aggregated	supports	A	Solid Neoplasm	2	Curated	civic	graph →
→ associated with	Solid Neoplasmcancer_family	supports	B

NTRK2 targets …TARGETS6 of 6
← targets	Taletrectinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Selitrectinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Repotrectinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Lestaurtinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Larotrectinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Entrectinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

NTRK2 has variant …HAS_VARIANTderived15 of 18show all (up to 200)
→ has variant	Fusionfusion 6 accepted CIViC evidence items	—	—	Sarcoma,Anaplastic Ependymoma,Glioblastoma+2	6	Curated	civic	graph →
→ has variant	Fusionfusion 5 accepted CIViC evidence items	—	—	Anaplastic Astrocytoma,Low Grade Glioma,Polymorphous Low Grade Neuroepithelial Tumor of the Young+1	5	Curated	civic	graph →
→ has variant	Fusionfusion 3 accepted CIViC evidence items	—	—	Solid Neoplasm	3	Curated	civic	graph →
→ has variant	Fusionfusion 2 accepted CIViC evidence items	—	—	Malignant Neoplasm,Acute Myeloid Leukemia	2	Curated	civic	graph →
→ has variant	Fusionfusion 2 accepted CIViC evidence items	—	—	Brain Glioblastoma,Ganglioglioma	2	Curated	civic	graph →
→ has variant	Amplificationamplification 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	e6::e7fusion 1 accepted CIViC evidence items	—	—	Osteosarcoma	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Sarcoma	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Ganglioglioma	1	Curated	civic	graph →
→ has variant	A203TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	e3::e16fusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

NTRK2 altered in cohorts of …ALTERED_INderived1 of 1
→ altered in cohorts of	Cutaneous Melanoma 37 / 696 cases (5.3 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →

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