NTRK2 Fusion

CI-VAR-00001374Explore in graph →CIViC 4536

Curated evidence

Evidence by cancer (5 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–5 of 5 evidence items across 5 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Anaplastic Astrocytoma1
QKI::NTRK2 Fusion	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	accepted	EID11450 Authors demonstrated that a flag-tagged QKI::NTRK2 (e6::e16) fusion was able to transform Ink4a−/−/Arf−/− astrocytes, and these cells induced astrocytomas when injected intracranially into mice. QKI… (full text at CIViC) PMID 27402815 · Ni et al., 2017 · Open in CIViC	civic
Low Grade Glioma1
QKI::NTRK2 Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	accepted	EID11437 From a retrospective review of 38,095 tumor samples from 33,997 patients that underwent fusion screening at Memorial Sloan Kettering Cancer Center, 87 tumors were found to be positive for an NTRK1, NT… (full text at CIViC) PMID 31375766 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Pilocytic Astrocytoma1
QKI::NTRK2 Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	accepted	EID11449 Whole genome sequencing of 96 pilocytic astrocytomas by the International Cancer Genome Consortium (ICGC) PedBrain Tumor Project identified QKI::NTRK2 (e6::e16) fusions in 2 cases (5 yo & 12 yo males)… (full text at CIViC) PMID 23817572 · Jones et al., 2013 · Open in CIViC	civic

Polymorphous Low Grade Neuroepithelial Tumor of the Young1
QKI::NTRK2 Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	accepted	EID11438 Molecular profiling of 13 patients with polymorphous low-grade neuroepithelial tumor of the young (PLNTY) at Mayo Clinic, identified 1 patient (15 yo female) with a QKI::NTRK2 (e6::e15) fusion. PMID 34363682 · Ida et al., 2021 · Open in CIViC	civic

Unmapped disease1unmapped disease
QKI::NTRK2 Fusion	(functional)	Functional	D	Supports Gain Of Function	2	accepted	EID11451 Authors demonstrated that a flag-tagged QKI::NTRK2 (e6::e16) fusion was able to transform Ink4a−/−/Arf−/− astrocytes, and these cells induced astrocytomas when injected intracranially into mice. Thi… (full text at CIViC) PMID 27402815 · Ni et al., 2017 · Open in CIViC	civic