NTRK2 Fusion

CI-VAR-00001230Explore in graph →CIViC 2396

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Myeloid Leukemia1
ETV6::NTRK2 Fusion	Larotrectinib	Predictive	C	Supports Sensitivity Response	4	accepted	EID6396 Rearrangements involving the neurotrophic receptor kinase genes (NTRK1, NTRK2, and NTRK3; hereafter referred to as TRK) produce oncogenic fusions in a wide variety of cancers in adults and children. I… (full text at CIViC) PMID 29920189 · Taylor et al., 2018 · Open in CIViC	civic
Malignant Neoplasm1
ETV6::NTRK2 Fusion	Entrectinib	Predictive	D	Supports Sensitivity Response	3	accepted	EID10099 BaF3 cells were transduced with a number of NTRK fusions. IC50 values were measured following treatment with entrectinib in cell viability assays: TPM3-NTRK1 (2.5nM), LMNA-NTRK1 (1.4nM), ETV6-NTRK1 (2… (full text at CIViC) PMID 26884591 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Thyroid Gland Papillary Carcinoma1
ETV6::NTRK2 Fusion AND TERT c.-124C.T	Larotrectinib	Predictive	C	Supports Sensitivity Response	2	submitted	EID11278 A 53 year old female patient had PTC treated with surgery and multiple brain metastases. TERT c.-124C.T mutation and ETV6::NTRK2 fusion was found in pleural biopsy and cerebellar resection specimens.… (full text at CIViC) PMID 35171659 · Park et al., 2022 · Open in CIViC	civic