NRAS

NRAS proto-oncogene, GTPase

Identifier: CI-GENE-00017216
Entity page: /gene/NRAS ↗
Edges: 93

Neighbours: 17 cancers15 variants1 drugs
Drawn: 33 of 33 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
NRAS associated with …ASSOCIATED_WITH19 of 19show fewer
→ associated with	Malignant Colorectal Neoplasmsubtype	supports	A	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ associated with	Melanomacancer_family 5 source records aggregated

NRAS targets …TARGETS1 of 1
← targets	Salirasibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

NRAS targets …TARGETS1 of 1

← targets

Salirasibsmall_molecule

—

INHIBITOR

—

Curated

NRAS has variant …HAS_VARIANTderived15 of 64show all (up to 200)
→ has variant	Mutationother 21 accepted CIViC evidence items	—	—	Malignant Neoplasm,Solid Neoplasm,Melanoma+2	21	Curated	civic	graph →
→ has variant	Q61SNV 8 accepted CIViC evidence items	—	—	Melanoma,Thyroid Gland Follicular Carcinoma,Cutaneous Melanoma+1	8	Curated	civic	graph →
→ has variant	Q61KSNV 8 accepted CIViC evidence items	—	—	Cutaneous Melanoma,Lung Non-Small Cell Carcinoma,Malignant Ovarian Serous Tumor+2	8	Curated	civic	graph →
→ has variant	G13RSNV 3 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm,Acral Lentiginous Melanoma	3	Curated	civic	graph →
→ has variant	Q61LSNV 3 accepted CIViC evidence items	—	—	Melanoma,Mucosal Melanoma,Malignant Colorectal Neoplasm	3	Curated	civic	graph →
→ has variant	Q61RSNV 3 accepted CIViC evidence items	—	—	Melanoma,Malignant Colorectal Neoplasm	3	Curated	civic	graph →
→ has variant	G12DSNV 2 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has variant	Gain 2 accepted CIViC evidence items	—	—	Melanoma	2	Curated	civic	graph →
→ has variant	G12SNV 1 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	1	Curated	civic	graph →
→ has variant	G12ASNV 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	G12CSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	G12/G13 1 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	1	Curated	civic	graph →
→ has variant	G13DSNV 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	Q179*SNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	Q61HSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →

NRAS altered in cohorts of …ALTERED_INderived9 of 9
→ altered in cohorts of	Melanomacancer_family 43 / 144 cases (30 %) · ssm · mel_dfci_2019 · largest of 3 cohorts	—	—	Melanoma	3	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanomacancer 207 / 696 cases (30 %) · ssm · mel_mskimpact_2020 · largest of 7 cohorts	—	—	Cutaneous Melanoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Multiple Myelomahematologic_malignancy 183 / 961 cases (19 %) · ssm · MMRF-COMMPASS · largest of 2 cohorts	—	—	Multiple Myeloma	2	Observed	gdc	graph →
→ altered in cohorts of	Acute Myeloid Leukemiahematologic_malignancy 119 / 903 cases (13 %) · ssm · aml_ohsu_2022 · largest of 5 cohorts	—	—	Acute Myeloid Leukemia	5	Observed	cbioportal	graph →
→ altered in cohorts of	B Lymphoblastic Leukemia/Lymphoma 88 / 739 cases (12 %) · ssm · bll_target_gdc	—	—	B Lymphoblastic Leukemia/Lymphoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Myelodysplastic Syndrome 492 / 4,231 cases (12 %) · ssm · mds_mskcc_2020 · largest of 2 cohorts	—	—	Myelodysplastic Syndrome	2	Observed	cbioportal	graph →
→ altered in cohorts of	Acute Lymphoblastic Leukemia 85 / 768 cases (11 %) · ssm · TARGET-ALL-P2	—	—	Acute Lymphoblastic Leukemia	1	Observed	gdc	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 20 / 224 cases (8.9 %) · ssm · coadread_tcga_pub · largest of 2 cohorts	—	—	Colorectal Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Thyroid Gland Papillary Carcinoma 39 / 496 cases (7.9 %) · ssm · thpa_tcga_gdc · largest of 4 cohorts	—	—	Thyroid Gland Papillary Carcinoma	4	Observed	cbioportal	graph →

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