Panitumumab

Curated

← predicts response to

NRAS Mutationother

resistance

Curated

← predicts response to

KRAS Mutationother

resistance

Curated

← predicts response to

KRAS G12/G13

2 source records aggregated

resistance

Curated

← predicts response to

EGFR Expressionexpression

sensitivity

Curated

← predicts response to

ERBB2 Amplificationamplification

resistance

Curated

← predicts response to

SMAD4 Mutationother

resistance

Curated

← predicts response to

FBXW7 Mutationother

resistance

Curated

← predicts response to

PIK3CA Mutationother

resistance

Curated

← predicts response to

PTEN Lossdeletion_cna

resistance

Curated

← predicts response to

resistance

Curated

← predicts response to

EGFR Amplificationamplification

sensitivity

Curated

← predicts response to

CDKN2A p16 Expressionexpression

sensitivity

Curated

← predicts response to

CDKN2A p16 Expressionexpression

resistance

Curated

← predicts response to

BRAF V600

resistance

Curated

← predicts response to

sensitivity

Curated

← predicts response to

EREG EXPRESSIONexpression

sensitivity

Curated

← predicts response to

AREG Expressionexpression

sensitivity

Curated

← predicts response to

KRAS G12VSNV

3 source records aggregated

resistance

Curated

← predicts response to

KRAS G12DSNV

3 source records aggregated

resistance

Curated

← predicts response to

KRAS G13DSNV

2 source records aggregated

resistance

Curated

← predicts response to

KRAS G12SSNV

2 source records aggregated

resistance

Curated

← predicts response to

Cholangiocarcinoma,Malignant Colorectal Neoplasm

2 source records aggregated

sensitivity

Curated

← predicts response to

NRAS G13RSNV

resistance

Curated

← predicts response to

KRAS G12ASNV

resistance

Curated

← predicts response to

KRAS G13VSNV

resistance

Curated

Colon Mucinous Adenocarcinoma

← predicts response to

KRAS Q22*SNV

resistance

Curated

← predicts response to

EGFR S492RSNV

sensitivity

Curated

← predicts response to

PIK3CA H1047RSNV

resistance

Curated

← predicts response to

resistance

Curated

← predicts response to

BRAF Amplificationamplification

resistance

Curated

← predicts response to

KRAS G12CSNV

resistance

Curated

← predicts response to

MET Amplificationamplification

resistance

Curated

← predicts response to

KRAS Mutationother

resistance

Curated

← predicts response to

PIK3CA E545KSNV

resistance

Curated

← predicts response to

EGFR G465RSNV

resistance

Curated

← predicts response to

KRAS G12RSNV

resistance

Curated

← predicts response to

EGFR R451CSNV

sensitivity

Curated

← predicts response to

BRAF G466VSNV

sensitivity

Curated

← predicts response to

EGFR K467TSNV

sensitivity

Curated

← predicts response to

sensitivity

Curated

← predicts response to

EGFR S492RSNV

sensitivity

Curated

← predicts response to

EGFR V441FSNV

resistance

Curated

Panitumumab targets …TARGETS1 of 1
→ targets	EGFR	—	INHIBITOR	—	1	Curated	chembl	graph →

Panitumumab targets …TARGETS1 of 1

→ targets

EGFR

—

INHIBITOR

—

Curated

Panitumumab investigated for …INVESTIGATED_FOR15 of 32show all (up to 200)
→ investigated for	Malignant Colorectal Neoplasmsubtype 3 source records aggregated	supports	A	Malignant Colorectal Neoplasm	3	Curated	civic	graph →
→ investigated for	Malignant Colorectal Neoplasmsubtype 14 source records aggregated	supports	B	Malignant Colorectal Neoplasm	14	Curated	civic	graph →
→ investigated for	Head and Neck Squamous Cell Carcinomasubtype 2 source records aggregated	supports	B	Head and Neck Squamous Cell Carcinoma	2	Curated	civic	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Colorectal Neoplasmsubtype	unknown	4	Colorectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Malignant Colorectal Neoplasmsubtype 23 source records aggregated	supports	C	Malignant Colorectal Neoplasm	23	Curated	civic	graph →
→ investigated for	Colon Mucinous Adenocarcinomasubtype	supports	C	Colon Mucinous Adenocarcinoma	1	Curated	civic	graph →
→ investigated for	Cholangiocarcinomasubtype	supports	C	Cholangiocarcinoma	1	Curated	civic	graph →
→ investigated for	Colon Neoplasmsubtype	unknown	3	Colon Neoplasm	1	Curated	chembl	graph →
→ investigated for	Head and Neck Neoplasmcancer_family	unknown	3	Head and Neck Neoplasm	1	Curated	chembl	graph →
→ investigated for	Squamous Cell Carcinomahistology	unknown	3	Squamous Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Malignant Colorectal Neoplasmsubtype 5 source records aggregated	supports	D	Malignant Colorectal Neoplasm	5	Curated	civic	graph →
→ investigated for	Gallbladder Neoplasmsubtype	unknown	2	Gallbladder Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Neoplasmcancer_family	unknown	2	Lung Neoplasm	1	Curated	chembl	graph →
→ investigated for	Triple-Negative Breast Carcinomamolecular_subtype	unknown	2	Triple-Negative Breast Carcinoma	1	Curated	chembl	graph →

Panitumumab investigated for …INVESTIGATED_FOR15 of 32show all (up to 200)

→ investigated for

3 source records aggregated

supports

Curated

→ investigated for

14 source records aggregated

supports

Curated

→ investigated for

Head and Neck Squamous Cell Carcinomasubtype

2 source records aggregated

supports

Curated

→ investigated for

Neoplasmcancer_family

unknown

Neoplasm

Curated

→ investigated for

Colorectal Neoplasmsubtype

unknown

Colorectal Neoplasm

Curated

→ investigated for

23 source records aggregated

supports

Curated

Colon Mucinous Adenocarcinoma

→ investigated for

Colon Mucinous Adenocarcinomasubtype

supports

Curated

→ investigated for

Cholangiocarcinomasubtype

supports

Cholangiocarcinoma

Curated

→ investigated for

Colon Neoplasmsubtype

unknown

Colon Neoplasm

Curated

→ investigated for

Head and Neck Neoplasmcancer_family

unknown

Head and Neck Neoplasm

Curated

→ investigated for

Squamous Cell Carcinomahistology

unknown

Squamous Cell Carcinoma

Curated

→ investigated for

5 source records aggregated

supports

Curated

→ investigated for

Gallbladder Neoplasmsubtype

unknown

Gallbladder Neoplasm

Curated

→ investigated for

Lung Neoplasmcancer_family

unknown

Lung Neoplasm

Curated

Triple-Negative Breast Carcinoma

→ investigated for

Triple-Negative Breast Carcinomamolecular_subtype

unknown

Curated

Panitumumab investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 76show all (up to 200)
→ investigated in trials for	Malignant Colorectal Neoplasmsubtype 84 trials (18 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	84	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colon Neoplasm 15 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colon Neoplasm	15	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Rectal Neoplasm 12 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Rectal Neoplasm	12	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinoma 10 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	10	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Carcinoma 9 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Carcinoma	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Neoplasmsubtype 9 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Neoplasm	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 9 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	9	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Esophageal Neoplasm 8 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Esophageal Neoplasm	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Head and Neck Neoplasm 7 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Head and Neck Neoplasm	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Lung Neoplasm 7 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Lung Neoplasm	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Pancreatic Neoplasm 7 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Pancreatic Neoplasm	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 7 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Head and Neck Squamous Cell Carcinomasubtype 6 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Head and Neck Squamous Cell Carcinoma	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Squamous Cell Carcinomahistology 5 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Squamous Cell Carcinoma	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Adenocarcinoma 4 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Adenocarcinoma	4	Observed	clinicaltrials	graph →

Panitumumab investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 76show all (up to 200)

→ investigated in trials for

84 trials (18 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Malignant Colon Neoplasm

15 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Colon Neoplasm

Observed

Malignant Rectal Neoplasm

→ investigated in trials for

12 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Rectal Neoplasm

Observed

Lung Non-Small Cell Carcinoma

→ investigated in trials for

10 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Lung Non-Small Cell Carcinoma

Observed

→ investigated in trials for

Colorectal Carcinoma

9 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Colorectal Carcinoma

Observed

→ investigated in trials for

Colorectal Neoplasmsubtype

9 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Colorectal Neoplasm

Observed

→ investigated in trials for

Malignant Neoplasm

9 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Neoplasm

Observed

Malignant Esophageal Neoplasm

→ investigated in trials for

8 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Esophageal Neoplasm

Observed

Malignant Head and Neck Neoplasm

→ investigated in trials for

7 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Head and Neck Neoplasm

Observed

→ investigated in trials for

Malignant Lung Neoplasm

7 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Lung Neoplasm

Observed

Malignant Pancreatic Neoplasm

→ investigated in trials for

7 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Pancreatic Neoplasm

Observed

→ investigated in trials for

Solid Neoplasm

7 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Solid Neoplasm

Observed

→ investigated in trials for

Head and Neck Squamous Cell Carcinomasubtype

6 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Squamous Cell Carcinomahistology

5 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Squamous Cell Carcinoma

Observed

Colorectal Adenocarcinoma

→ investigated in trials for

4 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Colorectal Adenocarcinoma

Observed

Malignant Solid Neoplasm,Primary Peritoneal Carcinoma,Malignant Female Reproductive System Neoplasm+2

Panitumumab studied in …STUDIED_INderived10 of 182show all (up to 200)
→ studied in	NCT05564377Phase 2 · recruiting Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial · 182 trials list this drug (35 active)	—	—	Malignant Solid Neoplasm,Primary Peritoneal Carcinoma,Malignant Female Reproductive System Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT06820463Phase 2 · recruiting A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer · 182 trials list this drug (35 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07659795Phase 2 · recruiting A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer · 182 trials list this drug (35 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05863195Phase 3 · recruiting Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial · 182 trials list this drug (35 active)	—	—	Colorectal Neoplasm,Colorectal Carcinoma,Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05786924Phase 1/Phase 2 · recruiting Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies · 182 trials list this drug (35 active)	—	—	Solid Neoplasm,Histiocytic and Dendritic Cell Neoplasm,Malignant Lung Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT05845450Phase 2 · recruiting Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN) · 182 trials list this drug (35 active)	—	—	Colorectal Carcinoma,Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06252649Phase 3 · recruiting Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation · 182 trials list this drug (35 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT03366155Phase 2 · completed Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver · 182 trials list this drug (35 active)	—	—	Colorectal Adenocarcinoma,Colorectal Carcinoma,Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04787341Phase 2 · completed PAnitumumab REchallenge Followed by REgorafenib Versus the Reverse Sequence · 182 trials list this drug (35 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04034173Phase 2 · terminated Optimal Anti-EGFR Treatment of mCRC Patients With Low-Frequency RAS Mutation · 182 trials list this drug (35 active)	—	—	Colorectal Neoplasm	1	Observed	clinicaltrials	graph →

Panitumumab studied in …STUDIED_INderived10 of 182show all (up to 200)

→ studied in

NCT05564377Phase 2 · recruiting

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial · 182 trials list this drug (35 active)

—

Observed

→ studied in

NCT06820463Phase 2 · recruiting

A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer · 182 trials list this drug (35 active)

—

Observed

→ studied in

NCT07659795Phase 2 · recruiting

A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer · 182 trials list this drug (35 active)

—

Observed

Colorectal Neoplasm,Colorectal Carcinoma,Malignant Colorectal Neoplasm

→ studied in

NCT05863195Phase 3 · recruiting

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial · 182 trials list this drug (35 active)

—

Observed

Solid Neoplasm,Histiocytic and Dendritic Cell Neoplasm,Malignant Lung Neoplasm+2

→ studied in

NCT05786924Phase 1/Phase 2 · recruiting

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies · 182 trials list this drug (35 active)

—

Observed

Colorectal Carcinoma,Malignant Colorectal Neoplasm

→ studied in

NCT05845450Phase 2 · recruiting

Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN) · 182 trials list this drug (35 active)

—

Observed

→ studied in

NCT06252649Phase 3 · recruiting

Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation · 182 trials list this drug (35 active)

—

Observed

Colorectal Adenocarcinoma,Colorectal Carcinoma,Malignant Colorectal Neoplasm

→ studied in

NCT03366155Phase 2 · completed

Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver · 182 trials list this drug (35 active)

—

Observed

→ studied in

NCT04787341Phase 2 · completed

PAnitumumab REchallenge Followed by REgorafenib Versus the Reverse Sequence · 182 trials list this drug (35 active)

—

Observed