Publication
Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (7)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 7
- cancerUveal Melanomacivic_curation1.00
- drugMirdametinibcivic_curation1.00
- drugSotrastaurin Acetatecivic_curation1.00
- geneGNA11civic_curation1.00
- geneGNAQcivic_curation1.00
- variantGNA11 Mutationcivic_curation1.00
- variantGNAQ Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24141786
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| GNA11 Mutation1 | ||||||||
| Mirdametinib + Sotrastaurin AcetateCombination | Uveal Melanoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID1952Preclinical study in uveal melanoma. Increased PKC activity was found in uveal melanoma cell lines with GNA11 or GNAQ mutations (n=6) compared to GNA wt cell lines (n=4) and could be induced by introd… (full text at CIViC) PMID 24141786 · Chen et al., 2014 · Open in CIViC | civic |
| GNAQ Mutation1 | ||||||||
| Mirdametinib + Sotrastaurin AcetateCombination | Uveal Melanoma | Predictive | D | Supports Sensitivity Response | 4 | accepted | EID1953Preclinical study in uveal melanoma. Increased PKC activity was found in uveal melanoma cell lines with GNA11 or GNAQ mutations (n=6) compared to GNA wt cell lines (n=4) and could be induced by introd… (full text at CIViC) PMID 24141786 · Chen et al., 2014 · Open in CIViC | civic |