Publication
Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerUveal Melanomacivic_curation1.00
- drugSelumetinibcivic_curation1.00
- geneGNA11civic_curation1.00
- geneGNAQcivic_curation1.00
- variantGNA11 Q209civic_curation1.00
- variantGNAQ Q209civic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24938562
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| GNA11 Q2091 | ||||||||
| Selumetinib | Uveal Melanoma | Predictive | B | Does Not Support Sensitivity Response | 3 | accepted | EID1212101 patients with metastatic uveal melanoma were randomized 1:1 to receive selumetinib or chemotherapy. Median PFS among patients randomized to chemotherapy was 7 weeks (95% CI, 4.3-8.4 weeks; median … (full text at CIViC) PMID 24938562 · Carvajal et al., 2014 · Open in CIViC | civic |
| GNAQ Q2091 | ||||||||
| Selumetinib | Uveal Melanoma | Predictive | B | Does Not Support Sensitivity Response | 3 | accepted | EID1213101 patients with metastatic uveal melanoma were randomized 1:1 to receive selumetinib or chemotherapy. Median PFS among patients randomized to chemotherapy was 7 weeks (95% CI, 4.3-8.4 weeks; median … (full text at CIViC) PMID 24938562 · Carvajal et al., 2014 · Open in CIViC | civic |