Publication
BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- cancerUveal Melanomacivic_curation1.00
- drugJQ1civic_curation1.00
- geneGNA11civic_curation1.00
- geneGNAQcivic_curation1.00
- variantGNA11 Mutationcivic_curation1.00
- variantGNAQ Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26397223
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| GNA11 Mutation1 | ||||||||
| JQ1 | Uveal Melanoma | Predictive | D | Supports Sensitivity Response | 1 | accepted | EID1211Preclinical study in uveal melanoma cell lines. Cell lines (n=5) with GNAQ (92.1, Omm1.3, Mel270, Mel202) or GNA11 (Omm1) mutation were more sensitive to BRD4 inhibition with JQ1 than GNAQ/11 wild typ… (full text at CIViC) PMID 26397223 · Ambrosini et al., 2015 · Open in CIViC | civic |
| GNAQ Mutation1 | ||||||||
| JQ1 | Uveal Melanoma | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID1210Preclinical study in uveal melanoma cell lines. Cell lines (n=4) with GNAQ mutation (92.1, Omm1.3, Mel270, Mel202) were more sensitive to BRD4 inhibition with JQ1 than GNAQ/GNA11 wild type (n=3) cell … (full text at CIViC) PMID 26397223 · Ambrosini et al., 2015 · Open in CIViC | civic |