Gene

EPOR

erythropoietin receptor

Explore in graph →CI-GENE-00044883HGNC:3416 ENSG00000187266 NCBI 2057 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (8)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–8 of 8 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
EPOR Overexpression3
(diagnostic)	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	A	Supports Positive	3	submitted	EID7023 The study showed that the EPOR gene rearrangements with immunoglobulin loci are associated with Ph-like molecular subtype of B-ALL, characterized by a gene-expression profile similar to that of the BC… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
(prognostic)	Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED	Prognostic	C	Supports Poor Outcome	3	submitted	EID7205 The manuscripts describes a small case series (6 patients) with the t(14;19)(q32;p13.1) involving the EPOR locus in 19p13.1 and the IGH locus in 14q32, which is predicted to result in EPOR overexpress… (full text at CIViC) PMID 24030742 ·

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Pediatric Low-Grade Glioma (CTF, Acta Neuropathol 2021) lgg_ctf_synodos_2025	Diffuse Glioma	Ssm	1	31

Literature

Linked publications (5)

25 per page, newest first.

pubmedPublishedShowing 1–5 of 5 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

B acute lymphoblastic leukemia with t(14;19)(q32;p13.1) involving IGH/EPOR: a clinically aggressive subset of disease.
· Mod Pathol · 2014 · PMID 24030742 · validated civic_curation pubmed
Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia.
· Cancer Cell · 2016 · PMID 26859458 · validated civic_curation pubmed
Concurrent EPOR::IGH fusion gene and numerous cytoplasmic granules in BCR::ABL1-like B-lymphoblastic leukemia.
· Pediatr Blood Cancer · 2024 · PMID 38302862 · validated civic_curation pubmed
From the archives of MD Anderson Cancer Center: BCR-ABL1-like B acute lymphoblastic leukemia with IGH/EPOR fusion.
· Ann Diagn Pathol · 2020 · PMID 32330662 · validated civic_curation

EPOR rearrangements1
(diagnostic)	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	B	Supports Positive	4	accepted	EID12397 This 2017 study is result of collaboration of multiple institutions and was led by St. Jude Children's Research Hospital team. The total cohort of 3115 B-ALL patients (all ages) was studied, with 212 … (full text at CIViC) PMID 26859458 · Iacobucci et al., 2016 · Open in CIViC	civic

EPOR rearrangements1

(diagnostic)

B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like

Diagnostic

Supports Positive

accepted

EID12397

This 2017 study is result of collaboration of multiple institutions and was led by St. Jude Children's Research Hospital team. The total cohort of 3115 B-ALL patients (all ages) was studied, with 212 … (full text at CIViC)

PMID 26859458 · Iacobucci et al., 2016 · Open in CIViC

civic

EPOR Fusion4
(diagnostic)	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	B	Supports Positive	4	accepted	EID12395 This MD Anderson Cancer Center study describes six adult patients (3 males and 3 females, median age 39 yo) with t(14;19)(q32;p13) resulting in IGH::EPOR. 3 patients did not receive any prior chemothe… (full text at CIViC) PMID 24030742 · Jaso et al., 2014 · Open in CIViC	civic
〃	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	C	Supports Positive	4	accepted	EID12393 In this 2024 case report the authors describe a case of BCR::ABL1-like B-ALL with unusual granular morphology in a female patient, 12 year old, with the following symptoms: paroxysmal headache, vomiti… (full text at CIViC) PMID 38302862 · Long et al., 2024 · Open in CIViC	civic
〃	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	C	Supports Positive	4	accepted	EID12394 This is a case report from MD Anderson Cancer Center. A 40yo Caucasian male patient was diagnosed with B-ALL with IGH::EPOR fusion. The patient received 4 cycles of R-hyper-CVAD and archived CR with M… (full text at CIViC) PMID 32330662 · Liu et al., 2020 · Open in CIViC	civic
〃	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	C	Supports Positive	4	accepted	EID12396 This 2021 study reports 3 adolescent/young adult patients with IGH::EPOR-positive B-ALL treated with post-induction chemotherapy combined with JAKi ruxolitinib or TKI ponatinib. Patient 1 was hispanic… (full text at CIViC) PMID 34196168 · Niswander et al., 2021 · Open in CIViC	civic

EPOR Fusion4

(diagnostic)

B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like

Diagnostic

Supports Positive

accepted

EID12395

This MD Anderson Cancer Center study describes six adult patients (3 males and 3 females, median age 39 yo) with t(14;19)(q32;p13) resulting in IGH::EPOR. 3 patients did not receive any prior chemothe… (full text at CIViC)

PMID 24030742 · Jaso et al., 2014 · Open in CIViC

civic

〃

B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like

Diagnostic

Supports Positive

accepted

EID12393

In this 2024 case report the authors describe a case of BCR::ABL1-like B-ALL with unusual granular morphology in a female patient, 12 year old, with the following symptoms: paroxysmal headache, vomiti… (full text at CIViC)

PMID 38302862 · Long et al., 2024 · Open in CIViC

civic

〃

B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like

Diagnostic

Supports Positive

accepted

EID12394

This is a case report from MD Anderson Cancer Center. A 40yo Caucasian male patient was diagnosed with B-ALL with IGH::EPOR fusion. The patient received 4 cycles of R-hyper-CVAD and archived CR with M… (full text at CIViC)

PMID 32330662 · Liu et al., 2020 · Open in CIViC

civic

〃

B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like

Diagnostic

Supports Positive

accepted

EID12396

This 2021 study reports 3 adolescent/young adult patients with IGH::EPOR-positive B-ALL treated with post-induction chemotherapy combined with JAKi ruxolitinib or TKI ponatinib. Patient 1 was hispanic… (full text at CIViC)

PMID 34196168 · Niswander et al., 2021 · Open in CIViC

civic