Publication
Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (2)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 2
- geneCRLF2civic_curation1.00
- variantCRLF2 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (4)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 20139093
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| CRLF2 Fusion2 | ||||||||
| (prognostic) | B Lymphoblastic Leukemia/LymphomaCURATED_BROADER | Prognostic | B | Supports Poor Outcome | 3 | submitted | EID6231CRLF2 overexpression due to P2RY8-CRLF2 fusion or IGH translocation was found in 14% of high risk pediatric B-ALL cases (in the cohort of 209 high-risk patients). 62% of the cases had IGH translocatio… (full text at CIViC) PMID 20139093 · Harvey et al., 2010 · Open in CIViC | civic |
| (oncogenic) | Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED | Oncogenic | C | Supports Oncogenicity | 5 | submitted | EID7239Gene expression profiling of 207 uniformly treated children with high-risk B-progenitor acute lymphoblastic leukemia enrolled in COG P9906 study identified 29/207 (14%) with increased expression of CR… (full text at CIViC) PMID 20139093 · Harvey et al., 2010 · Open in CIViC | civic |
| CRLF2 Fusion2 | ||||||||
| (prognostic) | Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED | Prognostic | B | Supports Poor Outcome | 5 | accepted | EID7238Gene expression profiling of 207 uniformly treated children with high-risk B-progenitor acute lymphoblastic leukemia enrolled in COG P9906 study identified 29/207 (14%) with increased expression of CR… (full text at CIViC) PMID 20139093 · Harvey et al., 2010 · Open in CIViC | civic |
| (oncogenic) | Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED | Oncogenic | C | Supports Oncogenicity | 2 | submitted | EID7240Gene expression profiling of 207 uniformly treated children with high-risk B-progenitor acute lymphoblastic leukemia enrolled in COG P9906 study identified 29/207 (14%) with increased expression of CR… (full text at CIViC) PMID 20139093 · Harvey et al., 2010 · Open in CIViC | civic |