Rare Neoplasm — Genomics

Rare Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

3 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Histiocytic and Dendritic Cell Neoplasms (MSK, 2025) hdcn_msk_2025MSK

1,270 cases with simple somatic mutation data · 1,270 cases total · 2026-01-20 · mapped to Histiocytic and Dendritic Cell Neoplasm EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BRAF	Ssm	224	1,270	17.6%	cbioportal
2	MAP2K1	Ssm	113	1,270	8.9%	cbioportal
3	DNMT3A	Ssm	104	1,270	8.2%	cbioportal
4	KRAS	Ssm	102	1,270	8%	cbioportal
5	TET2	Ssm	66	1,270	5.2%	cbioportal
6	NRAS	Ssm	33	1,270	2.6%	cbioportal
7	TP53	Ssm	28	1,270	2.2%	cbioportal
9	NF1

Data updated 22 days agoSource updated 2026-01-20

Histiocytosis Cobimetinib (MSK, Nature 2019) histiocytosis_cobi_msk_2019MSK

52 cases with simple somatic mutation data · 52 cases total · 2026-01-07 · mapped to Histiocytic and Dendritic Cell Neoplasm EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
3	FADS6

Myoepithelial Carcinomas of Soft Tissue (WCM, CSH Molecular Case Studies 2022) stmyec_wcm_2022WCM

12 cases with simple somatic mutation data · 12 cases total · 2026-01-13 · mapped to Malignant Myoepithelioma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	CORO2A

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.