Cancer Family
Pleural Mesothelial Neoplasm
CI-CAN-00000322Explore in graph →
Non-malignant34 active trials4 approved drugs6 evidence items
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Cancer Family
CI-CAN-00000322Explore in graph →
Genomics
5 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
87 cases with simple somatic mutation data · 87 cases total · 2026-01-16 · mapped to Pleural Mesothelial Neoplasm EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | NF2 | Ssm | 19 | 87 | 21.8% | cbioportal |
| 2 | BAP1 | Ssm | 17 | 87 | 19.5% | cbioportal |
| 4 | TTN | Ssm | 13 | 87 | 14.9% | cbioportal |
| 3 | TP53 | Ssm | 13 | 87 | 14.9% | cbioportal |
| 5 | NBPF10 | Ssm | 12 | 87 | 13.8% | cbioportal |
| 6 | MUC4 | Ssm | 9 | 87 | 10.3% | cbioportal |
| 7 | LATS2 | Ssm | 8 | 87 | 9.2% | cbioportal |
| 10 | WDR89 |
Data updated 22 days agoSource updated 2026-01-16
86 cases with simple somatic mutation data · 87 cases total · 2026-06-04 · mapped to Pleural Mesothelial Neoplasm EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 |
14 cases with simple somatic mutation data · 14 cases total · 2026-01-13 · mapped to Pleural Mesothelial Neoplasm EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 3 | SETDB1 |
22 cases with simple somatic mutation data · 22 cases total · 2026-01-13 · mapped to Pleural Mesothelial Neoplasm EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | BAP1 |
78 cases with simple somatic mutation data · 87 cases total · 2026-01-13 · mapped to Pleural Mesothelial Neoplasm EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | BAP1 | Ssm | 22 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 7 |
| 87 |
| 8% |
| cbioportal |
| 9 | SETD2 | Ssm | 7 | 87 | 8% | cbioportal |
| 8 | KRTAP4-11 | Ssm | 7 | 87 | 8% | cbioportal |
| 11 | FRG1BP | Ssm | 6 | 87 | 6.9% | cbioportal |
| 12 | PAK2 | Ssm | 6 | 87 | 6.9% | cbioportal |
| 14 | KRTAP4-7 | Ssm | 5 | 87 | 5.7% | cbioportal |
| 13 | ANHX | Ssm | 5 | 87 | 5.7% | cbioportal |
| 25 | TPTE2 | Ssm | 4 | 87 | 4.6% | cbioportal |
| 16 | FAT4 | Ssm | 4 | 87 | 4.6% | cbioportal |
| 17 | KRTAP4-9 | Ssm | 4 | 87 | 4.6% | cbioportal |
| 18 | LRP4 | Ssm | 4 | 87 | 4.6% | cbioportal |
| 19 | PTCH1 | Ssm | 4 | 87 | 4.6% | cbioportal |
| 20 | RANBP10 | Ssm | 4 | 87 | 4.6% | cbioportal |
| 21 | RLF | Ssm | 4 | 87 | 4.6% | cbioportal |
| 22 | SRGAP3 | Ssm | 4 | 87 | 4.6% | cbioportal |
| 23 | SYNE1 | Ssm | 4 | 87 | 4.6% | cbioportal |
| 24 | TDRD6 | Ssm | 4 | 87 | 4.6% | cbioportal |
| 15 | CNTNAP4 | Ssm | 4 | 87 | 4.6% | cbioportal |
| 63 | RDH16 | Ssm | 3 | 87 | 3.4% | cbioportal |
| 64 | RYR2 | Ssm | 3 | 87 | 3.4% | cbioportal |
| 65 | SETDB1 | Ssm | 3 | 87 | 3.4% | cbioportal |
| 66 | SHROOM1 | Ssm | 3 | 87 | 3.4% | cbioportal |
| 67 | SIRPB1 | Ssm | 3 | 87 | 3.4% | cbioportal |
| Ssm |
| 20 |
| 86 |
| 23.3% |
| cbioportal |
| 2 | BAP1 | Ssm | 18 | 86 | 20.9% | cbioportal |
| 3 | TP53 | Ssm | 14 | 86 | 16.3% | cbioportal |
| 4 | TTN | Ssm | 12 | 86 | 14% | cbioportal |
| 5 | LATS2 | Ssm | 8 | 86 | 9.3% | cbioportal |
| 6 | SETD2 | Ssm | 8 | 86 | 9.3% | cbioportal |
| 7 | FAT4 | Ssm | 4 | 86 | 4.7% | cbioportal |
| 8 | PTCH1 | Ssm | 4 | 86 | 4.7% | cbioportal |
| 17 | MROH2B | Ssm | 3 | 86 | 3.5% | cbioportal |
| 18 | NCOR1 | Ssm | 3 | 86 | 3.5% | cbioportal |
| 19 | NDST2 | Ssm | 3 | 86 | 3.5% | cbioportal |
| 20 | NEXMIF | Ssm | 3 | 86 | 3.5% | cbioportal |
| 21 | NLRP7 | Ssm | 3 | 86 | 3.5% | cbioportal |
| 22 | NLRP9 | Ssm | 3 | 86 | 3.5% | cbioportal |
| 23 | OGDHL | Ssm | 3 | 86 | 3.5% | cbioportal |
| 24 | PAPPA2 | Ssm | 3 | 86 | 3.5% | cbioportal |
| 25 | PHRF1 | Ssm | 3 | 86 | 3.5% | cbioportal |
| 26 | SDK1 | Ssm | 3 | 86 | 3.5% | cbioportal |
| 27 | SETDB1 | Ssm | 3 | 86 | 3.5% | cbioportal |
| 28 | SHROOM1 | Ssm | 3 | 86 | 3.5% | cbioportal |
| 29 | SRGAP3 | Ssm | 3 | 86 | 3.5% | cbioportal |
| 30 | SYNE1 | Ssm | 3 | 86 | 3.5% | cbioportal |
| 31 | TDRD6 | Ssm | 3 | 86 | 3.5% | cbioportal |
| 9 | ALPK3 | Ssm | 3 | 86 | 3.5% | cbioportal |
| 32 | USH2A | Ssm | 3 | 86 | 3.5% | cbioportal |
| 33 | VWF | Ssm | 3 | 86 | 3.5% | cbioportal |
| 34 | WWP2 | Ssm | 3 | 86 | 3.5% | cbioportal |
| 35 | ZNF469 | Ssm | 3 | 86 | 3.5% | cbioportal |
| 10 | CNTNAP2 | Ssm | 3 | 86 | 3.5% | cbioportal |
| 11 | CRACD | Ssm | 3 | 86 | 3.5% | cbioportal |
Data updated 22 days agoSource updated 2026-06-04
| Ssm |
| 4 |
| 4 |
| 100% |
| cbioportal |
| 1 | NF2 | Ssm | 13 | 14 | 92.9% | cbioportal |
| 2 | TP53 | Ssm | 6 | 14 | 42.9% | cbioportal |
| 6 | LATS2 | Ssm | 2 | 14 | 14.3% | cbioportal |
| 7 | STK11 | Ssm | 2 | 14 | 14.3% | cbioportal |
| 4 | BAP1 | Ssm | 2 | 14 | 14.3% | cbioportal |
| 5 | GNAS | Ssm | 2 | 14 | 14.3% | cbioportal |
| 32 | SESN3 | Ssm | 1 | 12 | 8.3% | cbioportal |
| 30 | NSD2 | Ssm | 1 | 12 | 8.3% | cbioportal |
| 16 | CDC42 | Ssm | 1 | 12 | 8.3% | cbioportal |
| 8 | ACVR1 | Ssm | 1 | 13 | 7.7% | cbioportal |
| 9 | ANKRD11 | Ssm | 1 | 13 | 7.7% | cbioportal |
| 18 | DICER1 | Ssm | 1 | 14 | 7.1% | cbioportal |
| 10 | AR | Ssm | 1 | 14 | 7.1% | cbioportal |
| 11 | ARID1A | Ssm | 1 | 14 | 7.1% | cbioportal |
| 12 | ASXL1 | Ssm | 1 | 14 | 7.1% | cbioportal |
| 13 | ATR | Ssm | 1 | 14 | 7.1% | cbioportal |
| 14 | AXIN1 | Ssm | 1 | 14 | 7.1% | cbioportal |
| 15 | BTK | Ssm | 1 | 14 | 7.1% | cbioportal |
| 17 | CUL3 | Ssm | 1 | 14 | 7.1% | cbioportal |
| 19 | ERCC3 | Ssm | 1 | 14 | 7.1% | cbioportal |
| 20 | FAT1 | Ssm | 1 | 14 | 7.1% | cbioportal |
| 21 | GRIN2A | Ssm | 1 | 14 | 7.1% | cbioportal |
| 22 | IRS2 | Ssm | 1 | 14 | 7.1% | cbioportal |
| 23 | MAX | Ssm | 1 | 14 | 7.1% | cbioportal |
| 24 | MEN1 | Ssm | 1 | 14 | 7.1% | cbioportal |
| 25 | NF1 | Ssm | 1 | 14 | 7.1% | cbioportal |
| 26 | NOTCH1 | Ssm | 1 | 14 | 7.1% | cbioportal |
| 27 | NOTCH3 | Ssm | 1 | 14 | 7.1% | cbioportal |
| 28 | NRAS | Ssm | 1 | 14 | 7.1% | cbioportal |
Data updated 22 days agoSource updated 2026-01-13
| 8 |
| 22 |
| 36.4% |
| cbioportal |
| 2 | NF2 | Ssm | 3 | 22 | 13.6% | cbioportal |
| 3 | TTN | Ssm | 3 | 22 | 13.6% | cbioportal |
| 4 | CUL1 | Ssm | 2 | 22 | 9.1% | cbioportal |
| 5 | OR56A3 | Ssm | 2 | 22 | 9.1% | cbioportal |
| 6 | PIK3C2B | Ssm | 2 | 22 | 9.1% | cbioportal |
| 7 | RDX | Ssm | 2 | 22 | 9.1% | cbioportal |
| 8 | TAOK1 | Ssm | 2 | 22 | 9.1% | cbioportal |
| 9 | TP53 | Ssm | 2 | 22 | 9.1% | cbioportal |
| 10 | AADACL4 | Ssm | 1 | 22 | 4.5% | cbioportal |
| 11 | AASS | Ssm | 1 | 22 | 4.5% | cbioportal |
| 12 | AATK | Ssm | 1 | 22 | 4.5% | cbioportal |
| 13 | ABCA7 | Ssm | 1 | 22 | 4.5% | cbioportal |
| 14 | ABCC11 | Ssm | 1 | 22 | 4.5% | cbioportal |
| 15 | ABCC9 | Ssm | 1 | 22 | 4.5% | cbioportal |
| 16 | ABHD11 | Ssm | 1 | 22 | 4.5% | cbioportal |
| 17 | ABHD2 | Ssm | 1 | 22 | 4.5% | cbioportal |
| 18 | ACKR5 | Ssm | 1 | 22 | 4.5% | cbioportal |
| 19 | ACP1 | Ssm | 1 | 22 | 4.5% | cbioportal |
| 20 | ACVR1B | Ssm | 1 | 22 | 4.5% | cbioportal |
| 21 | ADAMTS17 | Ssm | 1 | 22 | 4.5% | cbioportal |
| 22 | ADAMTSL1 | Ssm | 1 | 22 | 4.5% | cbioportal |
| 23 | ADGRE2 | Ssm | 1 | 22 | 4.5% | cbioportal |
| 24 | ADGRG4 | Ssm | 1 | 22 | 4.5% | cbioportal |
| 25 | AFM | Ssm | 1 | 22 | 4.5% | cbioportal |
| 26 | AGAP3 | Ssm | 1 | 22 | 4.5% | cbioportal |
| 27 | AHNAK | Ssm | 1 | 22 | 4.5% | cbioportal |
| 28 | AHNAK2 | Ssm | 1 | 22 | 4.5% | cbioportal |
| 29 | AKAP11 | Ssm | 1 | 22 | 4.5% | cbioportal |
| 30 | ALDH1B1 | Ssm | 1 | 22 | 4.5% | cbioportal |
Data updated 22 days agoSource updated 2026-01-13
| 78 |
| 28.2% |
| cbioportal |
| 2 | NF2 | Ssm | 19 | 78 | 24.4% | cbioportal |
| 3 | TP53 | Ssm | 11 | 78 | 14.1% | cbioportal |
| 4 | LATS2 | Ssm | 8 | 78 | 10.3% | cbioportal |
| 5 | SETD2 | Ssm | 8 | 78 | 10.3% | cbioportal |
| 6 | TTN | Ssm | 8 | 78 | 10.3% | cbioportal |
| 7 | FAT4 | Ssm | 4 | 78 | 5.1% | cbioportal |
| 8 | PTCH1 | Ssm | 4 | 78 | 5.1% | cbioportal |
| 9 | ALPK3 | Ssm | 3 | 78 | 3.8% | cbioportal |
| 10 | CRACD | Ssm | 3 | 78 | 3.8% | cbioportal |
| 11 | FLG | Ssm | 3 | 78 | 3.8% | cbioportal |
| 12 | MROH2B | Ssm | 3 | 78 | 3.8% | cbioportal |
| 13 | NCOR1 | Ssm | 3 | 78 | 3.8% | cbioportal |
| 14 | NDST2 | Ssm | 3 | 78 | 3.8% | cbioportal |
| 15 | NEXMIF | Ssm | 3 | 78 | 3.8% | cbioportal |
| 16 | NLRP9 | Ssm | 3 | 78 | 3.8% | cbioportal |
| 17 | OGDHL | Ssm | 3 | 78 | 3.8% | cbioportal |
| 18 | PHRF1 | Ssm | 3 | 78 | 3.8% | cbioportal |
| 19 | RYR2 | Ssm | 3 | 78 | 3.8% | cbioportal |
| 20 | SDK1 | Ssm | 3 | 78 | 3.8% | cbioportal |
| 21 | SETDB1 | Ssm | 3 | 78 | 3.8% | cbioportal |
| 22 | SHROOM1 | Ssm | 3 | 78 | 3.8% | cbioportal |
| 23 | SRGAP3 | Ssm | 3 | 78 | 3.8% | cbioportal |
| 24 | WWP2 | Ssm | 3 | 78 | 3.8% | cbioportal |
| 25 | ABCC8 | Ssm | 2 | 78 | 2.6% | cbioportal |
| 26 | ABLIM3 | Ssm | 2 | 78 | 2.6% | cbioportal |
| 27 | ACAP1 | Ssm | 2 | 78 | 2.6% | cbioportal |
| 28 | AGRN | Ssm | 2 | 78 | 2.6% | cbioportal |
| 29 | AKAP6 | Ssm | 2 | 78 | 2.6% | cbioportal |
| 30 | ALS2 | Ssm | 2 | 78 | 2.6% | cbioportal |
Data updated 22 days agoSource updated 2026-01-13