Cancer
Neoplasm of Uncertain Histogenesis
CI-CAN-00000034Explore in graph →
Non-malignant20,272 active trials259 approved drugs3,813 evidence items
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Cancer
CI-CAN-00000034Explore in graph →
Genomics
465 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
69 cases with simple somatic mutation data · 69 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 48 |
| 69 |
| 69.6% |
| cbioportal |
| 2 | PIK3CA | Ssm | 12 | 69 | 17.4% | cbioportal |
| 3 | PKD1 | Ssm | 8 | 69 | 11.6% | cbioportal |
| 4 | PTEN | Ssm | 7 | 69 | 10.1% | cbioportal |
| 8 | USH2A | Ssm | 6 | 69 | 8.7% | cbioportal |
| 5 | KMT2D | Ssm | 6 | 69 | 8.7% | cbioportal |
| 6 | PTPRD | Ssm | 6 | 69 | 8.7% | cbioportal |
| 7 | TSC2 | Ssm | 6 | 69 | 8.7% | cbioportal |
| 14 | PLCG1 | Ssm | 5 | 69 | 7.2% | cbioportal |
| 10 | CREBBP | Ssm | 5 | 69 | 7.2% | cbioportal |
| 12 | FAM47C | Ssm | 5 | 69 | 7.2% | cbioportal |
| 11 | EHMT2 | Ssm | 5 | 69 | 7.2% | cbioportal |
| 9 | ARID1B | Ssm | 5 | 69 | 7.2% | cbioportal |
| 13 | KMT2C | Ssm | 5 | 69 | 7.2% | cbioportal |
| 24 | FASN | Ssm | 4 | 69 | 5.8% | cbioportal |
| 23 | ERCC4 | Ssm | 4 | 69 | 5.8% | cbioportal |
| 22 | ERBB3 | Ssm | 4 | 69 | 5.8% | cbioportal |
| 19 | CDH1 | Ssm | 4 | 69 | 5.8% | cbioportal |
| 21 | ERBB2 | Ssm | 4 | 69 | 5.8% | cbioportal |
| 20 | COL2A1 | Ssm | 4 | 69 | 5.8% | cbioportal |
| 17 | ANKRD11 | Ssm | 4 | 69 | 5.8% | cbioportal |
| 18 | ARID1A | Ssm | 4 | 69 | 5.8% | cbioportal |
| 31 | TEK | Ssm | 4 | 69 | 5.8% | cbioportal |
| 15 | AFF2 | Ssm | 4 | 69 | 5.8% | cbioportal |
| 30 | PIK3R1 | Ssm | 4 | 69 | 5.8% | cbioportal |
| 29 | MAP3K1 | Ssm | 4 | 69 | 5.8% | cbioportal |
| 16 | AKT1 | Ssm | 4 | 69 | 5.8% | cbioportal |
| 28 | KCNB2 | Ssm | 4 | 69 | 5.8% | cbioportal |
| 27 | ITGB4 | Ssm | 4 | 69 | 5.8% | cbioportal |
| 26 | INSR | Ssm | 4 | 69 | 5.8% | cbioportal |
Data updated 22 days agoSource updated 2026-01-05