Cancer
Neoplasm of Uncertain Histogenesis
CI-CAN-00000034Explore in graph →
Non-malignant20,272 active trials259 approved drugs3,813 evidence items
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Cancer
CI-CAN-00000034Explore in graph →
Genomics
465 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
72 cases with simple somatic mutation data · 74 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 40 |
| 72 |
| 55.6% |
| cbioportal |
| 2 | KRAS | Ssm | 37 | 72 | 51.4% | cbioportal |
| 4 | TTN | Ssm | 29 | 72 | 40.3% | cbioportal |
| 3 | APC | Ssm | 29 | 72 | 40.3% | cbioportal |
| 5 | PIK3CA | Ssm | 22 | 72 | 30.6% | cbioportal |
| 6 | SYNE1 | Ssm | 19 | 72 | 26.4% | cbioportal |
| 7 | DNAH5 | Ssm | 18 | 72 | 25% | cbioportal |
| 9 | FAT3 | Ssm | 17 | 72 | 23.6% | cbioportal |
| 8 | CSMD1 | Ssm | 17 | 72 | 23.6% | cbioportal |
| 11 | SMAD4 | Ssm | 17 | 72 | 23.6% | cbioportal |
| 10 | FAT4 | Ssm | 17 | 72 | 23.6% | cbioportal |
| 12 | RYR2 | Ssm | 16 | 72 | 22.2% | cbioportal |
| 15 | OBSCN | Ssm | 15 | 72 | 20.8% | cbioportal |
| 16 | PLEC | Ssm | 15 | 72 | 20.8% | cbioportal |
| 13 | FBXW7 | Ssm | 15 | 72 | 20.8% | cbioportal |
| 14 | NEB | Ssm | 15 | 72 | 20.8% | cbioportal |
| 17 | HERC2 | Ssm | 14 | 72 | 19.4% | cbioportal |
| 20 | MYO15A | Ssm | 14 | 72 | 19.4% | cbioportal |
| 19 | LRP2 | Ssm | 14 | 72 | 19.4% | cbioportal |
| 22 | PCLO | Ssm | 14 | 72 | 19.4% | cbioportal |
| 21 | NRXN1 | Ssm | 14 | 72 | 19.4% | cbioportal |
| 18 | LAMA5 | Ssm | 14 | 72 | 19.4% | cbioportal |
| 23 | RYR1 | Ssm | 14 | 72 | 19.4% | cbioportal |
| 24 | ADGRV1 | Ssm | 13 | 72 | 18.1% | cbioportal |
| 34 | ROBO1 | Ssm | 13 | 72 | 18.1% | cbioportal |
| 25 | ATM | Ssm | 13 | 72 | 18.1% | cbioportal |
| 26 | ATP10A | Ssm | 13 | 72 | 18.1% | cbioportal |
| 28 | DNAH11 | Ssm | 13 | 72 | 18.1% | cbioportal |
| 36 | UNC80 | Ssm | 13 | 72 | 18.1% | cbioportal |
| 29 | DNHD1 | Ssm | 13 | 72 | 18.1% | cbioportal |
Data updated 22 days agoSource updated 2026-01-06