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Neoplasm by Special Category
CI-CAN-00000004Explore in graph →
Non-malignant21,331 active trials259 approved drugs3,859 evidence items
- NCIt
- C7062
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Other
CI-CAN-00000004Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
341 cases with simple somatic mutation data · 341 cases total · 2026-01-07 · mapped to Gastroesophageal Junction Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| TP53 |
| Ssm |
| 253 |
| 341 |
| 74.2% |
| cbioportal |
| 2 | ARID1A | Ssm | 44 | 341 | 12.9% | cbioportal |
| 164 | PREX2 | Ssm | 4 | 36 | 11.1% | cbioportal |
| 3 | CDKN2A | Ssm | 37 | 341 | 10.9% | cbioportal |
| 185 | DROSHA | Ssm | 3 | 28 | 10.7% | cbioportal |
| 4 | SMAD4 | Ssm | 33 | 341 | 9.7% | cbioportal |
| 5 | KRAS | Ssm | 31 | 341 | 9.1% | cbioportal |
| 6 | KMT2D | Ssm | 30 | 341 | 8.8% | cbioportal |
| 14 | ZFHX3 | Ssm | 17 | 206 | 8.3% | cbioportal |
| 7 | CDH1 | Ssm | 27 | 341 | 7.9% | cbioportal |
| 8 | PIK3CA | Ssm | 26 | 341 | 7.6% | cbioportal |
| 9 | ERBB4 | Ssm | 25 | 341 | 7.3% | cbioportal |
| 10 | EPHA5 | Ssm | 24 | 341 | 7% | cbioportal |
| 11 | PTPRT | Ssm | 23 | 341 | 6.7% | cbioportal |
| 12 | ERBB3 | Ssm | 21 | 341 | 6.2% | cbioportal |
| 37 | PGR | Ssm | 12 | 206 | 5.8% | cbioportal |
| 13 | PTPRD | Ssm | 19 | 341 | 5.6% | cbioportal |
| 18 | SMARCA4 | Ssm | 16 | 341 | 4.7% | cbioportal |
| 16 | NF1 | Ssm | 16 | 341 | 4.7% | cbioportal |
| 15 | APC | Ssm | 16 | 341 | 4.7% | cbioportal |
| 17 | PBRM1 | Ssm | 16 | 341 | 4.7% | cbioportal |
| 20 | NOTCH1 | Ssm | 15 | 341 | 4.4% | cbioportal |
| 19 | KMT2A | Ssm | 15 | 341 | 4.4% | cbioportal |
| 57 | POLD1 | Ssm | 9 | 206 | 4.4% | cbioportal |
| 52 | INHBA | Ssm | 9 | 206 | 4.4% | cbioportal |
| 25 | RHOA | Ssm | 14 | 333 | 4.2% | cbioportal |
| 24 | PTPRS | Ssm | 14 | 341 | 4.1% | cbioportal |
| 21 | AR | Ssm | 14 | 341 | 4.1% | cbioportal |
| 23 | CREBBP | Ssm | 14 | 341 | 4.1% | cbioportal |
| 22 | CIC | Ssm | 14 | 341 | 4.1% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07