Cancer
Malignant Rectal Neoplasm
CI-CAN-00008012Explore in graph →
Top-level388 active trials1 approved drugs5 evidence items
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Cancer
CI-CAN-00008012Explore in graph →
Clinical trials
1,551 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (153)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT03975491 | The Exercise And Colorectal Cancer Treatment Trial(EXACT) | active not recruiting | N/A | 60 | Pennington Biomedical Research CenterOTHER | 1 | Sep 22, 2025 | clinicaltrials |
| NCT07175636 | QL1706 With Short-Course Radiotherapy and Chemotherapy for MSS Rectal Cancer | not yet recruiting | Phase 2 | 66 | Sun Yat-sen UniversityOTHER | 0 | Sep 16, 2025 | clinicaltrials |
| NCT07161115 | Involve-site Radiotherapy Combined With Chemotherapy and Immunotherapy as Neoadjuvant Treatment for Locally Advanced Rectal Cancer(REFIRT) | not yet recruiting | Phase 2 | 60 | Longhao LiOTHER | 1 | Sep 15, 2025 | clinicaltrials |
| NCT06682793 | A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression(DENALI-1) | recruiting | Phase 1 / Phase 2 | 240 | A2 Biotherapeutics Inc.INDUSTRY | 1 | Sep 9, 2025 | clinicaltrials |
| NCT05938322 | Ketogenic Diet Compliance in Patients Undergoing Radiotherapy for Pelvic Cancers(KOMPARC) | recruiting | N/A | 194 | Fondazione Policlinico Universitario Agostino Gemelli IRCCSOTHER | 1 | Sep 5, 2025 | clinicaltrials |
| NCT06770270 | Pucotenlimab Plus Radiotherapy and Chemotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cance(PUCRT)(PUCRT) | recruiting | Phase 2 | 68 | Second Affiliated Hospital, Zhejiang University, School of MedicineOTHER | 1 | Sep 4, 2025 | clinicaltrials |
| NCT07150949 | Long-course Chemoradiotherapy or Short-course Radiotherapy Combined With CAPOX, PD-1antibody, and COX-2 Inhibitor for MSS Locally Advanced Rectal Cancer (SERRAC) | recruiting | Phase 2 | 138 | Fudan UniversityOTHER | 1 | Sep 2, 2025 | clinicaltrials |
| NCT05576480 | SCRT Sequential Penpulimab in Combination With CAPEOX in the Neoadjuvant Treatment of MSS Locally Advanced Rectal Cancer(SPARC) | recruiting | Phase 2 | 55 | Ruijin HospitalOTHER | 1 | Aug 28, 2025 | clinicaltrials |
| NCT07146334 | Low Powered Colorectal Anastomosis After Rectal Excision (OASIS)(OASIS) | not yet recruiting | — | 400 | Bordeaux Colorectal InstituteOTHER | 6 | Aug 28, 2025 | clinicaltrials |
| NCT07137000 | The Effect of Art Therapy in Patients Undergoing Colorectal Cancer | active not recruiting | N/A | 96 | Saglik Bilimleri UniversitesiOTHER | 1 | Aug 22, 2025 | clinicaltrials |
| NCT07134218 | Neoadjuvant Chemoradiotherapy Combined With Immunotherapy and Anti-angiogenesis in Treating Locally Advanced Rectal Cancer | not yet recruiting | Phase 2 / Phase 3 | 180 | Changhai HospitalOTHER | 1 | Aug 21, 2025 | clinicaltrials |
| NCT07134296 | Magnetic Resonance Imaging (MRI)-Guided Rectal Cancer Preservation Program | not yet recruiting | N/A | 32 | Clinica Universidad de Navarra, Universidad de NavarraOTHER | 0 | Aug 21, 2025 | clinicaltrials |
| NCT03283540 | Transanal Total Mesorectal Excision for Rectal Cancer on Anal Physiology + Fecal Incontinence | active not recruiting | — | 39 | Case Comprehensive Cancer CenterOTHER | 1 | Aug 17, 2025 | clinicaltrials |
| NCT06366841 | Stigma and Psychological profilE in REctal-anal caNcer pAtients(SERENA) | recruiting | — | 148 | Fondazione Policlinico Universitario Agostino Gemelli IRCCSOTHER | 1 | Aug 15, 2025 | clinicaltrials |
| NCT06087718 | Feasibility of the Maastro Applicator in Rectal Cancer | active not recruiting | N/A | 10 | Maastricht Radiation OncologyOTHER | 1 | Aug 14, 2025 | clinicaltrials |
| NCT05732389 | Immunotherapy in Patients With Early dMMR Rectal Cancer(RESET-R) | recruiting | Phase 2 | 39 | Odense University HospitalOTHER | 1 | Aug 7, 2025 | clinicaltrials |
| NCT07108348 | ADAR1 Expression Level in Rectal Cancer(ADAR1TNT) | recruiting | — | 50 | Necmettin Erbakan UniversityOTHER | 1 | Aug 7, 2025 | clinicaltrials |
| NCT07107815 | A Study On The Prediction of Neoadjuvant Efficacy For Rectal Cancer Based On MR Cytometry Imaging and Deep-radiomics | enrolling by invitation | — | 250 | Cancer Institute and Hospital, Chinese Academy of Medical SciencesOTHER | 1 | Aug 6, 2025 | clinicaltrials |
| NCT07108127 | Efficacy and Safety of Trastuzumab Biosimilars and Pertuzumab Biosimilars Combined With Chemotherapy for Neoadjuvant Treatment of Patients With Locally Advanced HER2-positive Rectal Cancer(NePHera) | recruiting | Phase 2 | 24 | Peking Union Medical College HospitalOTHER | 1 | Aug 6, 2025 | clinicaltrials |
| NCT07095439 | Efficacy and Toxicity of Total Neoadjuvant Sandwich Treatment Via Short Course Radiotherapy in the Treatment of Stage II and III Rectal Cancer Patients | recruiting | Phase 2 | 38 | Ain Shams UniversityOTHER | 1 | Jul 31, 2025 | clinicaltrials |
| NCT04852653 | A Prospective Feasibility Study Evaluating Extracellular Vesicles Obtained by Liquid Biopsy for Neoadjuvant Treatment Response Assessment in Rectal Cancer(RECC-EV) | active not recruiting | — | 58 | University Hospital, BordeauxOTHER | 1 | Jul 30, 2025 | clinicaltrials |
| NCT04927897 | DETECT: Target Volume for Rectal Endoluminal Radiation Boosting(DETECT) | recruiting | — | 50 | Maastricht Radiation OncologyOTHER | 1 | Jul 28, 2025 | clinicaltrials |
| NCT07074353 | Irinotecan Liposomes in Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer(CinClare-2) | not yet recruiting | Phase 3 | 360 | Zhejiang Cancer HospitalOTHER | 1 | Jul 25, 2025 | clinicaltrials |
| NCT06940388 | Total Neoadjuvant Treatment With or Without Tislelizumab for Locally Advanced Rectal Cancer.(TOTAL) | recruiting | Phase 2 | 134 | brenner baruchOTHER | 2 | Jul 24, 2025 | clinicaltrials |
| NCT07080411 | the Efficacy of MR-guided Online Adaptive Radiotherapy for Locally Advanced Rectal Cancer | not yet recruiting | N/A | 49 | Cancer Institute and Hospital, Chinese Academy of Medical SciencesOTHER | 0 | Jul 23, 2025 | clinicaltrials |
| NCT07070622 | Planed Organ Preservation for Low Rectal Cancer After Neoadjuvant Chemotherapy (OPLAR)(OPLAR) | recruiting | Phase 3 | 186 | West China HospitalOTHER | 1 | Jul 17, 2025 | clinicaltrials |
| NCT04922853 | Comparison of the Pathological Effect Between 2 and 4 Cycles Neoadjuvant CAPOX for Low/Intermediate Risk II/III Rectal Cancer(COPEC) | active not recruiting | Phase 3 | 554 | West China HospitalOTHER | 1 | Jul 11, 2025 | clinicaltrials |
| NCT07059949 | Short Course Radiotherapy Followed by CAPOX and Carrilizumab and Bevacizumab or Cetuximab for the Initial Treatment of Unresectable Metastatic Rectal Cancer(Union-mRC) | not yet recruiting | Phase 2 | 80 | Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyOTHER | 0 | Jul 11, 2025 | clinicaltrials |
| NCT07056374 | Adaptive Anastomosis for Anterior Resection in Sigmoid and Proximal Rectal Cancer or Premalignant Lesions(ADAPT) | recruiting | — | 165 | Amsterdam UMC, location VUmcOTHER | 1 | Jul 9, 2025 | clinicaltrials |
| NCT05663775 | Prophylactic Mesalamine to Prevent Colitis Following Treatment With Ipilimumab/Nivolumab (Ipi/Nivo)(IMPACT 1) | recruiting | Phase 2 | 20 | AHS Cancer Control AlbertaOTHER | 1 | Jun 27, 2025 | clinicaltrials |
| NCT06823297 | Can Neoadjuvant Chemoradiotherapy be Ommited in Mid-rectal Cancer(CANO) | not yet recruiting | — | 436 | Turkish Society of Colon and Rectal SurgeryOTHER | 1 | Jun 27, 2025 | clinicaltrials |
| NCT07040098 | Optimizing Immunotherapy Combined With Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer(STELLARIII) | recruiting | Phase 2 | 228 | Cancer Institute and Hospital, Chinese Academy of Medical SciencesOTHER | 1 | Jun 26, 2025 | clinicaltrials |
| NCT07035600 | Walking and Sitting Difficulties After Rectal Cancer Surgery(WASA) | not yet recruiting | N/A | 300 | Sahlgrenska University HospitalOTHER | 1 | Jun 25, 2025 | clinicaltrials |
| NCT06057831 | PET/MRI in Rectal Cancer | not yet recruiting | Phase 2 | 40 | AHS Cancer Control AlbertaOTHER | 0 | Jun 18, 2025 | clinicaltrials |
| NCT07020247 | Personalized Long-course Radiotherapy Plus Chemotherapy With or Without Immunotherapy for LARC: PALACE Study | recruiting | Phase 3 | 184 | West China HospitalOTHER | 1 | Jun 13, 2025 | clinicaltrials |
| NCT06209099 | Organ Preservation First Strategy and Intentional Watch and Wait for MRI Defined Low-risk Rectal Cancer | recruiting | N/A | 96 | Peking University Cancer Hospital & InstituteOTHER | 1 | Jun 12, 2025 | clinicaltrials |
| NCT06761287 | Optimizing Patient Selection for Surgery Using Pathologic Analysis Following Neoadjuvant Therapy in Locally Advanced Rectal Cancer(OPAL) | recruiting | N/A | 20 | Centre Hospitalier Universitaire Saint PierreOTHER | 1 | May 30, 2025 | clinicaltrials |
| NCT05551052 | CRC Detection Reliable Assessment With Blood(CRC-DRAW) | active not recruiting | — | 196 | New Day DiagnosticsNETWORK | 1 | May 29, 2025 | clinicaltrials |
| NCT06214988 | Selective Defunctioning Stoma in Low Anterior Resection for Rectal Cancer(SELSA) | recruiting | N/A | 212 | Skane University HospitalOTHER | 1 | May 21, 2025 | clinicaltrials |
| NCT05914766 | An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer(PATHWAYS) | recruiting | N/A | 80 | Massachusetts General HospitalOTHER | 1 | May 18, 2025 | clinicaltrials |
| NCT06968221 | Bovine Reinforcement in Stomach, Colorectal and Lung Operation | recruiting | Phase 3 | 172 | Shanghai Cingularbio Co. LtdINDUSTRY | 1 | May 15, 2025 | clinicaltrials |
| NCT06814093 | Robotic Versus Laparoscopic Surgery for Middle and Low Rectal Cancer: a Target Trial Emulation | active not recruiting | — | 2,702 | Xu jianminOTHER | 1 | May 9, 2025 | clinicaltrials |
| NCT05179824 | Tempus Priority Study: A Pan-tumor Observational Study | active not recruiting | — | 1,000 | Tempus AIINDUSTRY | 1 | May 6, 2025 | clinicaltrials |
| NCT06956976 | Preservation Vs. Dissection of No. 253 Lymph Nodes of Robotic Resection for Mid/Low Rectal Cancer(REAL2) | not yet recruiting | N/A | 1,596 | Fudan UniversityOTHER | 1 | May 4, 2025 | clinicaltrials |
| NCT05965531 | Treating Locally Advanced Rectal Cancer With TAS-102 Chemotherapy Plus Neoadjuvant Radiotherapy(TASLARC) | recruiting | Phase 2 | 65 | Sun Yat-sen UniversityOTHER | 1 | Apr 29, 2025 | clinicaltrials |
| NCT06940778 | LIQUID BIOPSY FOCUSING ON CIRCULATING TUMOR CELLS AND CIRCULATING TUMOR DNA AS PRECISION MEDICINE IN GASTROINTESTINAL TUMORS(BLENTI) | active not recruiting | — | 273 | Hospital do CoracaoOTHER | 1 | Apr 27, 2025 | clinicaltrials |
| NCT06943690 | Safety and Efficacy Study of Single-port Robotic Versus Multi-port Robotic Radical Rectal Cancer Surgery | not yet recruiting | N/A | 212 | Ruijin HospitalOTHER | 1 | Apr 24, 2025 | clinicaltrials |
| NCT06923345 | Modified Long-Course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for MSS/pMMR High-risk Mid/Low LARC (MODIFI-RC-I) | recruiting | Phase 2 | 80 | Sixth Affiliated Hospital, Sun Yat-sen UniversityOTHER | 1 | Apr 18, 2025 | clinicaltrials |
| NCT06931808 | Intestinal Microbiota Transplantation, Radiochemotherapy and Sintilimab in Localized Advanced Colon Cancer | enrolling by invitation | Phase 4 | 20 | First Affiliated Hospital of Ningbo UniversityNETWORK | 1 | Apr 17, 2025 | clinicaltrials |
| NCT06931873 | Neoadjuvant Radiochemotherapy Combined With QL1706 for Low Rectal Cancer | not yet recruiting | Early Phase 1 | 60 | Changhai HospitalOTHER | 0 | Apr 17, 2025 | clinicaltrials |
Data updated 23 days agoSource updated Sep 22, 2025source: clinicaltrials