Clinical trial · Interventional
The Exercise And Colorectal Cancer Treatment Trial
The Exercise And Colorectal Cancer Treatment (EXACT) Trial
NCT03975491CI-TRIAL-00095565EXACTactive not recruitingN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study will examine the biologic processes through which exercise may prevent disease recurrence in patients who have completed treatment for colorectal cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Moderate-Intensity Aerobic Exercise | Behavioral | — | UNRESOLVED |
| Wait-List Control | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Aerobic Exercise
- description
- Moderate-intensity aerobic exercise
- interventionNames
- Behavioral: Moderate-Intensity Aerobic Exercise
- type
- SHAM_COMPARATOR
- label
- Control
- description
- Wait-list control
- interventionNames
- Behavioral: Wait-List Control
Primary outcomes (2)
- measure
- The Percentage Change in High-sensitivity C-reactive Protein
- timeFrame
- Baseline, 12 weeks
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥18 years * Histologically-confirmed stage I-III colorectal cancer * Completed surgical resection * Completed chemotherapy (if applicable) * Completed radiotherapy (if applicable) * Provide written approval by physician or other qualified healthcare provider * No planned major surgery during the study period (including colostomy reversal; chemotherapy infusion port removal is permitted) * Readiness to exercise \[as determined by a modified version the Physical Activity Readiness Questionnaire (PAR-Q) * Allow the collection and storage of specimens and data for future use * Willing to be randomized Exclusion Criteria: * Evidence of metastatic colon cancer * Concurrently actively treated other cancer (except non-melanoma skin cancer or in situ cancers) * Currently enrolled in another clinical trial of weight loss, physical activity, or dietary intervention * Current body mass greater than or equal to 181 kg * Unable to provide a baseline fasting blood sample * Unable or unwilling to give informed consent * Unable or unwilling to be randomized * Or any other condition that may impede testing of the study hypothesis or make it unsafe to engage in the exercise program (as determined by the investigative team)
References
Publications (3)
- BACKGROUNDCompton SLE, Yang S, Maniscalco LS, Muhsen RA, Shrestha P, Wu X, Woodard KT, Zunica ERM, Cho E, Wall RL, Brown J, Jayaraman A, Kirby BJ, Gilmore LA, Greenway FL, Spielmann G, Brown JC. A randomized trial of aerobic exercise in colorectal cancer: Rationale, design, recruitment, and exercise adherence results. Contemp Clin Trials. 2024 Nov;146:107702. doi: 10.1016/j.cct.2024.107702. Epub 2024 Oct 1. PMID 39362405
- BACKGROUNDCho E, Chodzko M, Compton SLE, Yang S, Heymsfield S, Spielmann G, Brown JC. Effects of aerobic exercise on body composition and exerkines in colorectal cancer survivors. Front Sports Act Living. 2025 Jun 26;7:1579221. doi: 10.3389/fspor.2025.1579221. eCollection 2025. PMID 40642656
- RESULTBrown JC, Compton SLE, Kang A, Jayaraman A, Gilmore LA, Kirby BJ, Greenway FL, Yang S, Spielmann G. Effects of exercise on inflammation, circulating tumor cells, and circulating tumor DNA in colorectal cancer. J Sport Health Sci. 2025 Dec;14:101036. doi: 10.1016/j.jshs.2025.101036. Epub 2025 Mar 17. PMID 40107449