Malignant Anorectal Neoplasm — Genomics

Malignant Anorectal Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

4 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Colorectal Adenocarcinoma (MSK, 2026) crc_msk_2026MSK

7,237 cases with simple somatic mutation data · 7,237 cases total · 2026-09-01 · mapped to Rectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	5,400	7,237	74.6%	cbioportal
2	TP53	Ssm	5,295	7,237	73.2%	cbioportal
3	KRAS	Ssm	3,096	7,237	42.8%	cbioportal
4	PIK3CA	Ssm	1,486	7,237	20.5%	cbioportal
5	FBXW7	Ssm	1,127	7,237	15.6%	cbioportal
6	TCF7L2	Ssm	1,088	7,035	15.5%	cbioportal
7	SMAD4	Ssm	1,078	7,237	14.9%	cbioportal
8

Data updated 22 days agoSource updated 2026-09-01

Colorectal Cancer Radiation (MSK, 2024) rectal_radiation_msk_2024MSK

48 cases with simple somatic mutation data · 48 cases total · 2026-01-20 · mapped to Rectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm

Rectal Adenocarcinoma (TCGA GDC, 2025) read_tcga_gdcTCGA GDC

155 cases with simple somatic mutation data · 171 cases total · 2026-01-13 · mapped to Rectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	126	155

Rectum Adenocarcinoma TCGA-READTCGA

171 cases with simple somatic mutation data · 172 cases total · Data Release 46.0 · mapped to Rectal Adenocarcinoma ALIAS

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTPRT

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.