Gastroesophageal Junction Carcinoma — Genomics

Gastroesophageal Junction Carcinoma — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

19 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Esophageal Adenocarcinoma (DFCI, Nat Genet 2013) esca_broadDFCI

151 cases with simple somatic mutation data · 151 cases total · 2026-01-07 · mapped to Esophageal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Esophageal Adenocarcinoma (TCGA GDC, 2025) esca_tcga_gdcTCGA GDC

185 cases with simple somatic mutation data · 186 cases total · 2026-01-13 · mapped to Esophageal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	156	185	84.3%	cbioportal
2	TTN	Ssm	75	185	40.5%	cbioportal
3	MUC16	Ssm	40	185	21.6%	cbioportal
4	CSMD3	Ssm	35	185	18.9%	cbioportal
5	SYNE1	Ssm	33	185	17.8%	cbioportal
6	FLG	Ssm	27	185	14.6%	cbioportal
7	LRP1B	Ssm	27	185	14.6%	cbioportal
8	DNAH5	Ssm	26	185	14.1%	cbioportal
9	PCLO	Ssm	25	185	13.5%	cbioportal
10	HMCN1	Ssm	24	185	13%	cbioportal
12	RYR2	Ssm	22	185	11.9%	cbioportal
11	KMT2D	Ssm	22	185	11.9%	cbioportal
13	CSMD1	Ssm	20	185	10.8%	cbioportal
15	ZNF804B	Ssm	19	185	10.3%	cbioportal
14	FAT3	Ssm	19	185	10.3%	cbioportal
17	SPTA1	Ssm	18	185	9.7%	cbioportal
16	SACS	Ssm	18	185	9.7%	cbioportal
18	UNC13C	Ssm	18	185	9.7%	cbioportal
20	NOTCH1	Ssm	17	185	9.2%	cbioportal
21	RYR3	Ssm	17	185	9.2%	cbioportal
19	NFE2L2	Ssm	17	185	9.2%	cbioportal
24	LAMA1	Ssm	16	185	8.6%	cbioportal
23	DYNC2H1	Ssm	16	185	8.6%	cbioportal
22	COL11A1	Ssm	16	185	8.6%	cbioportal
27	PIK3CA	Ssm	16	185	8.6%	cbioportal
26	PCDH15	Ssm	16	185	8.6%	cbioportal
25	OBSCN	Ssm	16	185	8.6%	cbioportal
28	ADGRV1	Ssm	15	185	8.1%	cbioportal
29	ARID1A	Ssm	15	185	8.1%	cbioportal
30	CNTNAP5	Ssm	15	185	8.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Esophageal Adenocarcinoma (TCGA, PanCancer Atlas) esca_tcga_pan_can_atlas_2018TCGA

182 cases with simple somatic mutation data · 182 cases total · 2026-06-05 · mapped to Esophageal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	158	182	86.8%	cbioportal
2	TTN	Ssm	75	182	41.2%	cbioportal
3	MUC16	Ssm	43	182	23.6%	cbioportal
4	SYNE1	Ssm	37	182	20.3%	cbioportal
5	CSMD3	Ssm	35	182	19.2%	cbioportal
6	FLG	Ssm	32	182	17.6%	cbioportal
8	LRP1B	Ssm	31	182	17%	cbioportal
7	HMCN1	Ssm	31	182	17%	cbioportal
9	DNAH5	Ssm	30	182	16.5%	cbioportal
10	PCLO	Ssm	27	182	14.8%	cbioportal
11	RYR2	Ssm	23	182	12.6%	cbioportal
13	KMT2D	Ssm	22	182	12.1%	cbioportal
12	EYS	Ssm	22	182	12.1%	cbioportal
14	CSMD1	Ssm	21	182	11.5%	cbioportal
15	FAT3	Ssm	20	182	11%	cbioportal
17	SPTA1	Ssm	20	182	11%	cbioportal
18	UNC13C	Ssm	20	182	11%	cbioportal
16	PKHD1L1	Ssm	20	182	11%	cbioportal
20	OBSCN	Ssm	19	182	10.4%	cbioportal
19	DYNC2H1	Ssm	19	182	10.4%	cbioportal
21	PCDH15	Ssm	19	182	10.4%	cbioportal
22	ZNF804B	Ssm	19	182	10.4%	cbioportal
25	USH2A	Ssm	18	182	9.9%	cbioportal
23	NFE2L2	Ssm	18	182	9.9%	cbioportal
24	SACS	Ssm	18	182	9.9%	cbioportal
30	PIK3CA	Ssm	17	182	9.3%	cbioportal
26	CNTNAP5	Ssm	17	182	9.3%	cbioportal
27	LAMA1	Ssm	17	182	9.3%	cbioportal
28	LRRK2	Ssm	17	182	9.3%	cbioportal
29	MUC4	Ssm	17	182	9.3%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Esophageal Cancer-TRAP Project (MSK, Lancet Oncol 2020) egc_trap_msk_2020MSK

63 cases with simple somatic mutation data · 68 cases total · 2026-01-07 · mapped to Gastroesophageal Junction Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	45	63	71.4%	cbioportal
3	TTN	Ssm	11	31	35.5%	cbioportal
6	PCLO	Ssm	7	31	22.6%	cbioportal
7	SYNE1	Ssm	7	31	22.6%	cbioportal
5	LRP1B	Ssm	7	31	22.6%	cbioportal
11	OBSCN	Ssm	6	31	19.4%	cbioportal
10	CSMD2	Ssm	6	31	19.4%	cbioportal
2	CDKN2A	Ssm	11	63	17.5%	cbioportal
16	DNAH8	Ssm	5	31	16.1%	cbioportal
18	MUC16	Ssm	5	31	16.1%	cbioportal
23	UNC13C	Ssm	5	31	16.1%	cbioportal
19	MXRA5	Ssm	5	31	16.1%	cbioportal
21	TENM4	Ssm	5	31	16.1%	cbioportal
14	CSMD3	Ssm	5	31	16.1%	cbioportal
15	CUBN	Ssm	5	31	16.1%	cbioportal
13	COL4A4	Ssm	5	31	16.1%	cbioportal
4	PTPRT	Ssm	10	63	15.9%	cbioportal
33	DMD	Ssm	4	31	12.9%	cbioportal
24	ABCA13	Ssm	4	31	12.9%	cbioportal
30	CNTN6	Ssm	4	31	12.9%	cbioportal
31	CNTNAP4	Ssm	4	31	12.9%	cbioportal
32	CSMD1	Ssm	4	31	12.9%	cbioportal
25	ANKS1B	Ssm	4	31	12.9%	cbioportal
35	FAT4	Ssm	4	31	12.9%	cbioportal
36	FBN2	Ssm	4	31	12.9%	cbioportal
37	GLI3	Ssm	4	31	12.9%	cbioportal
41	MAGEC1	Ssm	4	31	12.9%	cbioportal
45	PABPC3	Ssm	4	31	12.9%	cbioportal
43	NRK	Ssm	4	31	12.9%	cbioportal
44	NRXN1	Ssm	4	31	12.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Esophageal Carcinoma (TCGA, Firehose Legacy) esca_tcgaTCGA

185 cases with simple somatic mutation data · 186 cases total · 2026-01-07 · mapped to Esophageal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	153	185	82.7%	cbioportal
2	TTN	Ssm	97	185	52.4%	cbioportal
3	MUC16	Ssm	51	185	27.6%	cbioportal
4	SYNE1	Ssm	44	185	23.8%	cbioportal
5	CSMD3	Ssm	40	185	21.6%	cbioportal
6	DNAH5	Ssm	35	185	18.9%	cbioportal
7	HMCN1	Ssm	34	185	18.4%	cbioportal
8	LRP1B	Ssm	33	185	17.8%	cbioportal
10	KMT2D	Ssm	32	185	17.3%	cbioportal
9	FLG	Ssm	32	185	17.3%	cbioportal
11	RYR2	Ssm	31	185	16.8%	cbioportal
14	USH2A	Ssm	29	185	15.7%	cbioportal
12	MUC4	Ssm	29	185	15.7%	cbioportal
13	PCLO	Ssm	29	185	15.7%	cbioportal
16	OBSCN	Ssm	27	185	14.6%	cbioportal
15	CSMD1	Ssm	27	185	14.6%	cbioportal
17	PKHD1L1	Ssm	26	185	14.1%	cbioportal
18	FAT3	Ssm	25	185	13.5%	cbioportal
20	SPTA1	Ssm	25	185	13.5%	cbioportal
19	FAT4	Ssm	25	185	13.5%	cbioportal
21	MUC12	Ssm	24	185	13%	cbioportal
23	RYR3	Ssm	23	185	12.4%	cbioportal
24	XIRP2	Ssm	23	185	12.4%	cbioportal
22	DYNC2H1	Ssm	23	185	12.4%	cbioportal
26	DST	Ssm	22	185	11.9%	cbioportal
25	ADGRV1	Ssm	22	185	11.9%	cbioportal
27	ATM	Ssm	21	185	11.4%	cbioportal
30	NEB	Ssm	21	185	11.4%	cbioportal
29	EYS	Ssm	21	185	11.4%	cbioportal
28	CDKN2A	Ssm	21	185	11.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Esophageal Carcinoma (TCGA, Nature 2017) stes_tcga_pubTCGA

518 cases with simple somatic mutation data · 559 cases total · 2026-01-13 · mapped to Gastroesophageal Junction Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	309	518	59.7%	cbioportal
2	TTN	Ssm	276	518	53.3%	cbioportal
3	MUC16	Ssm	171	518	33%	cbioportal
4	SYNE1	Ssm	134	518	25.9%	cbioportal
5	LRP1B	Ssm	125	518	24.1%	cbioportal
6	CSMD3	Ssm	121	518	23.4%	cbioportal
7	FLG	Ssm	108	518	20.8%	cbioportal
8	ARID1A	Ssm	106	518	20.5%	cbioportal
9	CSMD1	Ssm	104	518	20.1%	cbioportal
10	OBSCN	Ssm	104	518	20.1%	cbioportal
11	PCLO	Ssm	103	518	19.9%	cbioportal
12	DNAH5	Ssm	99	518	19.1%	cbioportal
13	FAT4	Ssm	99	518	19.1%	cbioportal
14	RYR2	Ssm	98	518	18.9%	cbioportal
15	HMCN1	Ssm	92	518	17.8%	cbioportal
16	KMT2D	Ssm	91	518	17.6%	cbioportal
17	FAT3	Ssm	88	518	17%	cbioportal
18	SPTA1	Ssm	86	518	16.6%	cbioportal
19	ZFHX4	Ssm	80	518	15.4%	cbioportal
20	USH2A	Ssm	79	518	15.3%	cbioportal
21	PIK3CA	Ssm	77	518	14.9%	cbioportal
22	PCDH15	Ssm	76	518	14.7%	cbioportal
23	RYR3	Ssm	74	518	14.3%	cbioportal
24	LRRK2	Ssm	72	518	13.9%	cbioportal
25	SACS	Ssm	72	518	13.9%	cbioportal
26	DNAH11	Ssm	71	518	13.7%	cbioportal
27	DNAH7	Ssm	70	518	13.5%	cbioportal
29	DMD	Ssm	67	518	12.9%	cbioportal
28	AHNAK2	Ssm	67	518	12.9%	cbioportal
30	MUC4	Ssm	67	518	12.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Esophagogastric Cancer (MSK, Clin Cancer Res 2022) egc_msk_tp53_ccr_2022MSK

237 cases with simple somatic mutation data · 237 cases total · 2026-01-07 · mapped to Gastroesophageal Junction Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	185	237	78.1%	cbioportal
2	ARID1A	Ssm	39	237	16.5%	cbioportal
3	CDKN2A	Ssm	39	237	16.5%	cbioportal
5	PREX2	Ssm	24	198	12.1%	cbioportal
4	SMARCA4	Ssm	25	237	10.5%	cbioportal
6	PIK3CA	Ssm	22	237	9.3%	cbioportal
9	SMAD4	Ssm	21	237	8.9%	cbioportal
7	ERBB4	Ssm	21	237	8.9%	cbioportal
8	PTPRD	Ssm	21	237	8.9%	cbioportal
10	KMT2D	Ssm	20	237	8.4%	cbioportal
11	APC	Ssm	19	237	8%	cbioportal
14	ZFHX3	Ssm	17	228	7.5%	cbioportal
13	PTPRT	Ssm	17	237	7.2%	cbioportal
12	KRAS	Ssm	17	237	7.2%	cbioportal
15	EPHA5	Ssm	16	237	6.8%	cbioportal
16	BRCA2	Ssm	15	237	6.3%	cbioportal
22	KMT2B	Ssm	12	198	6.1%	cbioportal
17	ARID2	Ssm	13	237	5.5%	cbioportal
18	KMT2A	Ssm	13	237	5.5%	cbioportal
21	ERBB2	Ssm	12	237	5.1%	cbioportal
19	AR	Ssm	12	237	5.1%	cbioportal
20	CREBBP	Ssm	12	237	5.1%	cbioportal
23	PTPRS	Ssm	12	237	5.1%	cbioportal
31	RNF43	Ssm	11	237	4.6%	cbioportal
24	CIC	Ssm	11	237	4.6%	cbioportal
25	ERBB3	Ssm	11	237	4.6%	cbioportal
26	FLT4	Ssm	11	237	4.6%	cbioportal
27	IRS2	Ssm	11	237	4.6%	cbioportal
28	NF1	Ssm	11	237	4.6%	cbioportal
30	NTRK3	Ssm	11	237	4.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Esophagogastric Cancer (MSK, Clin Cancer Res 2023) egc_trap_ccr_msk_2023MSK

64 cases with simple somatic mutation data · 64 cases total · 2026-01-07 · mapped to Gastroesophageal Junction Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	44	64	68.8%	cbioportal
2	TTN	Ssm	27	64	42.2%	cbioportal
3	PCLO	Ssm	17	64	26.6%	cbioportal
4	LRP1B	Ssm	14	64	21.9%	cbioportal
5	MUC16	Ssm	14	64	21.9%	cbioportal
6	SYNE1	Ssm	14	64	21.9%	cbioportal
7	CDKN2A	Ssm	12	64	18.8%	cbioportal
9	CSMD2	Ssm	11	64	17.2%	cbioportal
11	OBSCN	Ssm	11	64	17.2%	cbioportal
10	CUBN	Ssm	11	64	17.2%	cbioportal
8	COL4A4	Ssm	11	64	17.2%	cbioportal
14	DNAH8	Ssm	10	64	15.6%	cbioportal
15	MYO18B	Ssm	10	64	15.6%	cbioportal
16	TENM4	Ssm	10	64	15.6%	cbioportal
12	CNTNAP4	Ssm	10	64	15.6%	cbioportal
13	DNAH5	Ssm	10	64	15.6%	cbioportal
17	ABCA13	Ssm	9	64	14.1%	cbioportal
19	CSMD3	Ssm	9	64	14.1%	cbioportal
20	FLG	Ssm	9	64	14.1%	cbioportal
21	MYH6	Ssm	9	64	14.1%	cbioportal
22	MYT1L	Ssm	9	64	14.1%	cbioportal
23	RIMS2	Ssm	9	64	14.1%	cbioportal
24	RYR3	Ssm	9	64	14.1%	cbioportal
18	APOB	Ssm	9	64	14.1%	cbioportal
28	HMCN1	Ssm	8	64	12.5%	cbioportal
31	TTC6	Ssm	8	64	12.5%	cbioportal
30	SDK1	Ssm	8	64	12.5%	cbioportal
29	PTPRT	Ssm	8	64	12.5%	cbioportal
26	EPHA3	Ssm	8	64	12.5%	cbioportal
27	FAT4	Ssm	8	64	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Gastric Adenocarcinoma (TMUCIH, PNAS 2015) egc_tmucih_2015TMUCIH

78 cases with simple somatic mutation data · 78 cases total · 2026-01-07 · mapped to Gastroesophageal Junction Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	36	78	46.2%	cbioportal
2	TTN	Ssm	34	78	43.6%	cbioportal
3	ARID1A	Ssm	17	78	21.8%	cbioportal
4	MUC16	Ssm	14	78	17.9%	cbioportal
8	ZFHX4	Ssm	13	78	16.7%	cbioportal
5	COL11A1	Ssm	13	78	16.7%	cbioportal
6	CSMD3	Ssm	13	78	16.7%	cbioportal
7	PCLO	Ssm	13	78	16.7%	cbioportal
9	LRP1B	Ssm	12	78	15.4%	cbioportal
10	SYNE1	Ssm	12	78	15.4%	cbioportal
11	CDH1	Ssm	11	78	14.1%	cbioportal
12	HMCN1	Ssm	11	78	14.1%	cbioportal
14	FAT4	Ssm	10	78	12.8%	cbioportal
15	PIK3CA	Ssm	10	78	12.8%	cbioportal
13	DNAH5	Ssm	10	78	12.8%	cbioportal
16	APC	Ssm	9	78	11.5%	cbioportal
17	DNAH7	Ssm	9	78	11.5%	cbioportal
21	USH2A	Ssm	9	78	11.5%	cbioportal
20	PCDH9	Ssm	9	78	11.5%	cbioportal
19	FREM2	Ssm	9	78	11.5%	cbioportal
18	FAT3	Ssm	9	78	11.5%	cbioportal
26	FSIP2	Ssm	8	78	10.3%	cbioportal
29	MAGEC1	Ssm	8	78	10.3%	cbioportal
28	LRP2	Ssm	8	78	10.3%	cbioportal
27	LRBA	Ssm	8	78	10.3%	cbioportal
25	DYNC2H1	Ssm	8	78	10.3%	cbioportal
24	DMD	Ssm	8	78	10.3%	cbioportal
23	DCHS2	Ssm	8	78	10.3%	cbioportal
22	AKAP6	Ssm	8	78	10.3%	cbioportal
35	UNC13C	Ssm	8	78	10.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Gastric Cancer (OncoSG, 2018) stad_oncosg_2018OncoSG

147 cases with simple somatic mutation data · 147 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	70	147	47.6%	cbioportal
2	TTN	Ssm	59	147	40.1%	cbioportal
3	SYNE1	Ssm	36	147	24.5%	cbioportal
4	LRP1B	Ssm	32	147	21.8%	cbioportal
5	MUC16	Ssm	29	147	19.7%	cbioportal
6	DNAH5	Ssm	25	147	17%	cbioportal
7	CSMD1	Ssm	22	147	15%	cbioportal
8	NEB	Ssm	21	147	14.3%	cbioportal
9	FAT3	Ssm	20	147	13.6%	cbioportal
10	OBSCN	Ssm	20	147	13.6%	cbioportal
11	MUC19	Ssm	19	147	12.9%	cbioportal
13	RYR2	Ssm	18	147	12.2%	cbioportal
12	CSMD3	Ssm	18	147	12.2%	cbioportal
15	XIRP2	Ssm	18	147	12.2%	cbioportal
14	USH2A	Ssm	18	147	12.2%	cbioportal
22	SPTA1	Ssm	17	147	11.6%	cbioportal
20	PCLO	Ssm	17	147	11.6%	cbioportal
19	NBEA	Ssm	17	147	11.6%	cbioportal
18	EYS	Ssm	17	147	11.6%	cbioportal
17	ARID1A	Ssm	17	147	11.6%	cbioportal
16	ABCA13	Ssm	17	147	11.6%	cbioportal
21	SACS	Ssm	17	147	11.6%	cbioportal
25	RYR1	Ssm	16	147	10.9%	cbioportal
23	PAPPA2	Ssm	16	147	10.9%	cbioportal
24	RIMS2	Ssm	16	147	10.9%	cbioportal
26	SYNE2	Ssm	16	147	10.9%	cbioportal
30	HMCN1	Ssm	15	147	10.2%	cbioportal
27	ANK2	Ssm	15	147	10.2%	cbioportal
28	COL11A1	Ssm	15	147	10.2%	cbioportal
29	FSIP2	Ssm	15	147	10.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Metastatic Esophagogastric Cancer (MSK, Cancer Discovery 2017) egc_msk_2017MSK

341 cases with simple somatic mutation data · 341 cases total · 2026-01-07 · mapped to Gastroesophageal Junction Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	253	341	74.2%	cbioportal
2	ARID1A	Ssm	44	341	12.9%	cbioportal
164	PREX2	Ssm	4	36	11.1%	cbioportal
3	CDKN2A	Ssm	37	341	10.9%	cbioportal
185	DROSHA	Ssm	3	28	10.7%	cbioportal
4	SMAD4	Ssm	33	341	9.7%	cbioportal
5	KRAS	Ssm	31	341	9.1%	cbioportal
6	KMT2D	Ssm	30	341	8.8%	cbioportal
14	ZFHX3	Ssm	17	206	8.3%	cbioportal
7	CDH1	Ssm	27	341	7.9%	cbioportal
8	PIK3CA	Ssm	26	341	7.6%	cbioportal
9	ERBB4	Ssm	25	341	7.3%	cbioportal
10	EPHA5	Ssm	24	341	7%	cbioportal
11	PTPRT	Ssm	23	341	6.7%	cbioportal
12	ERBB3	Ssm	21	341	6.2%	cbioportal
37	PGR	Ssm	12	206	5.8%	cbioportal
13	PTPRD	Ssm	19	341	5.6%	cbioportal
16	NF1	Ssm	16	341	4.7%	cbioportal
15	APC	Ssm	16	341	4.7%	cbioportal
18	SMARCA4	Ssm	16	341	4.7%	cbioportal
17	PBRM1	Ssm	16	341	4.7%	cbioportal
20	NOTCH1	Ssm	15	341	4.4%	cbioportal
19	KMT2A	Ssm	15	341	4.4%	cbioportal
52	INHBA	Ssm	9	206	4.4%	cbioportal
57	POLD1	Ssm	9	206	4.4%	cbioportal
25	RHOA	Ssm	14	333	4.2%	cbioportal
22	CIC	Ssm	14	341	4.1%	cbioportal
23	CREBBP	Ssm	14	341	4.1%	cbioportal
24	PTPRS	Ssm	14	341	4.1%	cbioportal
21	AR	Ssm	14	341	4.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Stomach Adenocarcinoma TCGA-STADTCGA

443 cases with simple somatic mutation data · 443 cases total · Data Release 46.0 · mapped to Gastric Adenocarcinoma ALIAS

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	CSMD3	Ssm	305	443	68.8%	gdc
2	RIMS2	Ssm	302	443	68.2%	gdc
3	FER1L6	Ssm	299	443	67.5%	gdc
4	TTN	Ssm	297	443	67%	gdc
5	MYC	Ssm	296	443	66.8%	gdc
7	TG	Ssm	295	443	66.6%	gdc
6	ADCY8	Ssm	295	443	66.6%	gdc
8	POU5F1B	Ssm	294	443	66.4%	gdc
9	ASAP1	Ssm	293	443	66.1%	gdc
11	UBR5	Ssm	293	443	66.1%	gdc
10	LRP12	Ssm	293	443	66.1%	gdc
12	DDX27	Ssm	292	443	65.9%	gdc
14	ZNF831	Ssm	290	443	65.5%	gdc
13	VPS13B	Ssm	290	443	65.5%	gdc
15	COL14A1	Ssm	290	443	65.5%	gdc
19	PLEC	Ssm	289	443	65.2%	gdc
18	DIDO1	Ssm	289	443	65.2%	gdc
17	NFATC2	Ssm	289	443	65.2%	gdc
16	GSDMC	Ssm	289	443	65.2%	gdc
21	WASHC5	Ssm	288	443	65%	gdc
23	KLHL38	Ssm	288	443	65%	gdc
22	ANXA13	Ssm	288	443	65%	gdc
20	PKHD1L1	Ssm	288	443	65%	gdc
29	PTPRT	Ssm	287	443	64.8%	gdc
27	FBXO32	Ssm	287	443	64.8%	gdc
24	FAM91A1	Ssm	287	443	64.8%	gdc
25	EXT1	Ssm	287	443	64.8%	gdc
26	ATAD2	Ssm	287	443	64.8%	gdc
28	SQLE	Ssm	287	443	64.8%	gdc
30	LRATD2	Ssm	287	443	64.8%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Stomach Adenocarcinoma (Pfizer and UHK, Nat Genet 2014) stad_pfizer_uhongkongPfizer and UHK

100 cases with simple somatic mutation data · 100 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	55	100	55%	cbioportal
2	TTN	Ssm	41	100	41%	cbioportal
3	MUC16	Ssm	24	100	24%	cbioportal
4	SYNE1	Ssm	22	100	22%	cbioportal
5	CSMD1	Ssm	19	100	19%	cbioportal
6	ARID1A	Ssm	18	100	18%	cbioportal
7	FLG	Ssm	17	100	17%	cbioportal
8	DNAH5	Ssm	16	100	16%	cbioportal
9	CDH1	Ssm	15	100	15%	cbioportal
11	HYDIN	Ssm	14	100	14%	cbioportal
12	LRP1B	Ssm	14	100	14%	cbioportal
10	FAT3	Ssm	14	100	14%	cbioportal
15	OBSCN	Ssm	13	100	13%	cbioportal
14	KMT2C	Ssm	13	100	13%	cbioportal
13	DNAH14	Ssm	13	100	13%	cbioportal
17	SPTA1	Ssm	13	100	13%	cbioportal
16	RYR3	Ssm	13	100	13%	cbioportal
18	SDK1	Ssm	12	100	12%	cbioportal
23	MDN1	Ssm	11	100	11%	cbioportal
30	XIRP2	Ssm	11	100	11%	cbioportal
29	TGFBR2	Ssm	11	100	11%	cbioportal
28	SYNE2	Ssm	11	100	11%	cbioportal
27	RYR1	Ssm	11	100	11%	cbioportal
26	RNF43	Ssm	11	100	11%	cbioportal
25	PREX2	Ssm	11	100	11%	cbioportal
19	ABCA13	Ssm	11	100	11%	cbioportal
20	CACNA1C	Ssm	11	100	11%	cbioportal
21	COBLL1	Ssm	11	100	11%	cbioportal
22	HRNR	Ssm	11	100	11%	cbioportal
24	PCLO	Ssm	11	100	11%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Stomach Adenocarcinoma (TCGA, Firehose Legacy) stad_tcgaTCGA

478 cases with simple somatic mutation data · 478 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	217	478	45.4%	cbioportal
2	TP53	Ssm	190	478	39.7%	cbioportal
3	MUC16	Ssm	134	478	28%	cbioportal
4	LRP1B	Ssm	104	478	21.8%	cbioportal
5	ARID1A	Ssm	102	478	21.3%	cbioportal
6	SYNE1	Ssm	101	478	21.1%	cbioportal
7	OBSCN	Ssm	95	478	19.9%	cbioportal
8	FLG	Ssm	86	478	18%	cbioportal
9	FAT4	Ssm	85	478	17.8%	cbioportal
10	CSMD1	Ssm	84	478	17.6%	cbioportal
11	PCLO	Ssm	80	478	16.7%	cbioportal
12	RYR2	Ssm	77	478	16.1%	cbioportal
15	HMCN1	Ssm	73	478	15.3%	cbioportal
13	DNAH5	Ssm	73	478	15.3%	cbioportal
14	FAT3	Ssm	73	478	15.3%	cbioportal
16	KMT2D	Ssm	69	478	14.4%	cbioportal
17	SPTA1	Ssm	69	478	14.4%	cbioportal
18	ZFHX4	Ssm	69	478	14.4%	cbioportal
19	PIK3CA	Ssm	65	478	13.6%	cbioportal
20	HSPG2	Ssm	63	478	13.2%	cbioportal
21	DNAH7	Ssm	62	478	13%	cbioportal
22	PCDH15	Ssm	61	478	12.8%	cbioportal
23	RYR3	Ssm	61	478	12.8%	cbioportal
24	SACS	Ssm	60	478	12.6%	cbioportal
25	ACVR2A	Ssm	59	478	12.3%	cbioportal
28	USH2A	Ssm	59	478	12.3%	cbioportal
27	LRRK2	Ssm	59	478	12.3%	cbioportal
26	DNAH11	Ssm	59	478	12.3%	cbioportal
30	CUBN	Ssm	58	478	12.1%	cbioportal
29	AHNAK2	Ssm	58	478	12.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Stomach Adenocarcinoma (TCGA GDC, 2025) stad_tcga_gdcTCGA GDC

431 cases with simple somatic mutation data · 443 cases total · 2026-01-14 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	221	431	51.3%	cbioportal
2	TP53	Ssm	198	431	45.9%	cbioportal
3	MUC16	Ssm	135	431	31.3%	cbioportal
4	ARID1A	Ssm	116	431	26.9%	cbioportal
5	LRP1B	Ssm	115	431	26.7%	cbioportal
6	CSMD3	Ssm	102	431	23.7%	cbioportal
7	SYNE1	Ssm	102	431	23.7%	cbioportal
8	FAT4	Ssm	92	431	21.3%	cbioportal
9	FLG	Ssm	85	431	19.7%	cbioportal
10	PCLO	Ssm	81	431	18.8%	cbioportal
11	HMCN1	Ssm	80	431	18.6%	cbioportal
13	ZFHX4	Ssm	77	431	17.9%	cbioportal
12	ACVR2A	Ssm	77	431	17.9%	cbioportal
14	DNAH5	Ssm	76	431	17.6%	cbioportal
15	OBSCN	Ssm	74	431	17.2%	cbioportal
16	SPTA1	Ssm	74	431	17.2%	cbioportal
17	RYR2	Ssm	73	431	16.9%	cbioportal
19	FAT3	Ssm	71	431	16.5%	cbioportal
18	CSMD1	Ssm	71	431	16.5%	cbioportal
20	KMT2D	Ssm	68	431	15.8%	cbioportal
21	PIK3CA	Ssm	67	431	15.5%	cbioportal
22	DST	Ssm	66	431	15.3%	cbioportal
23	SACS	Ssm	65	431	15.1%	cbioportal
24	PCDH15	Ssm	62	431	14.4%	cbioportal
25	PLEC	Ssm	62	431	14.4%	cbioportal
26	DMD	Ssm	61	431	14.2%	cbioportal
27	LRRK2	Ssm	60	431	13.9%	cbioportal
28	SYNE2	Ssm	59	431	13.7%	cbioportal
29	UBR5	Ssm	59	431	13.7%	cbioportal
30	COL12A1	Ssm	58	431	13.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Stomach Adenocarcinoma (TCGA, Nature 2014) stad_tcga_pubTCGA

295 cases with simple somatic mutation data · 295 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	166	295	56.3%	cbioportal
2	TP53	Ssm	138	295	46.8%	cbioportal
3	MUC16	Ssm	101	295	34.2%	cbioportal
4	ARID1A	Ssm	90	295	30.5%	cbioportal
5	LRP1B	Ssm	78	295	26.4%	cbioportal
6	SYNE1	Ssm	76	295	25.8%	cbioportal
7	FAT4	Ssm	70	295	23.7%	cbioportal
8	CSMD3	Ssm	68	295	23.1%	cbioportal
9	PCLO	Ssm	67	295	22.7%	cbioportal
10	HMCN1	Ssm	66	295	22.4%	cbioportal
11	CSMD1	Ssm	65	295	22%	cbioportal
12	KMT2D	Ssm	65	295	22%	cbioportal
13	FLG	Ssm	62	295	21%	cbioportal
14	RYR2	Ssm	59	295	20%	cbioportal
15	PIK3CA	Ssm	57	295	19.3%	cbioportal
16	SPTA1	Ssm	57	295	19.3%	cbioportal
17	DNAH5	Ssm	56	295	19%	cbioportal
18	FAT3	Ssm	56	295	19%	cbioportal
19	OBSCN	Ssm	55	295	18.6%	cbioportal
20	ZFHX4	Ssm	53	295	18%	cbioportal
21	RYR3	Ssm	50	295	16.9%	cbioportal
22	PCDH15	Ssm	49	295	16.6%	cbioportal
23	RNF43	Ssm	49	295	16.6%	cbioportal
24	ADGRV1	Ssm	48	295	16.3%	cbioportal
25	PLEC	Ssm	48	295	16.3%	cbioportal
26	DMD	Ssm	47	295	15.9%	cbioportal
27	SACS	Ssm	47	295	15.9%	cbioportal
28	COL12A1	Ssm	46	295	15.6%	cbioportal
29	RYR1	Ssm	46	295	15.6%	cbioportal
30	TSPOAP1	Ssm	46	295	15.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Stomach Adenocarcinoma (TCGA, PanCancer Atlas) stad_tcga_pan_can_atlas_2018TCGA

436 cases with simple somatic mutation data · 440 cases total · 2026-06-04 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	235	436	53.9%	cbioportal
2	TP53	Ssm	213	436	48.9%	cbioportal
3	MUC16	Ssm	146	436	33.5%	cbioportal
4	LRP1B	Ssm	120	436	27.5%	cbioportal
5	SYNE1	Ssm	111	436	25.5%	cbioportal
6	ARID1A	Ssm	110	436	25.2%	cbioportal
7	CSMD3	Ssm	107	436	24.5%	cbioportal
8	FLG	Ssm	103	436	23.6%	cbioportal
9	FAT4	Ssm	94	436	21.6%	cbioportal
10	CSMD1	Ssm	88	436	20.2%	cbioportal
11	PCLO	Ssm	88	436	20.2%	cbioportal
12	HMCN1	Ssm	86	436	19.7%	cbioportal
13	OBSCN	Ssm	81	436	18.6%	cbioportal
14	DNAH5	Ssm	80	436	18.3%	cbioportal
16	ZFHX4	Ssm	79	436	18.1%	cbioportal
15	RYR2	Ssm	79	436	18.1%	cbioportal
17	FAT3	Ssm	77	436	17.7%	cbioportal
18	SPTA1	Ssm	77	436	17.7%	cbioportal
19	KMT2D	Ssm	73	436	16.7%	cbioportal
20	PCDH15	Ssm	72	436	16.5%	cbioportal
21	PIK3CA	Ssm	71	436	16.3%	cbioportal
22	AHNAK2	Ssm	68	436	15.6%	cbioportal
24	SACS	Ssm	64	436	14.7%	cbioportal
23	PLEC	Ssm	64	436	14.7%	cbioportal
29	RYR3	Ssm	62	436	14.2%	cbioportal
30	USH2A	Ssm	62	436	14.2%	cbioportal
25	COL12A1	Ssm	62	436	14.2%	cbioportal
26	CUBN	Ssm	62	436	14.2%	cbioportal
27	DNAH11	Ssm	62	436	14.2%	cbioportal
28	LAMA1	Ssm	62	436	14.2%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Stomach Adenocarcinoma (UHK, Nat Genet 2011) stad_uhongkongUHK

22 cases with simple somatic mutation data · 22 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	9	22	40.9%	cbioportal
2	DNAH7	Ssm	7	22	31.8%	cbioportal
5	LRP1B	Ssm	6	22	27.3%	cbioportal
4	CSMD3	Ssm	6	22	27.3%	cbioportal
3	ARID1A	Ssm	6	22	27.3%	cbioportal
7	SLCO6A1	Ssm	6	22	27.3%	cbioportal
6	PTEN	Ssm	6	22	27.3%	cbioportal
9	TTN	Ssm	5	22	22.7%	cbioportal
8	PCDH15	Ssm	5	22	22.7%	cbioportal
24	USH2A	Ssm	4	22	18.2%	cbioportal
10	ACVR2A	Ssm	4	22	18.2%	cbioportal
11	BAZ2B	Ssm	4	22	18.2%	cbioportal
12	COPB2	Ssm	4	22	18.2%	cbioportal
13	DNAH3	Ssm	4	22	18.2%	cbioportal
14	EIF3A	Ssm	4	22	18.2%	cbioportal
15	FMN2	Ssm	4	22	18.2%	cbioportal
16	HERC2	Ssm	4	22	18.2%	cbioportal
17	HMCN1	Ssm	4	22	18.2%	cbioportal
18	LMAN1	Ssm	4	22	18.2%	cbioportal
19	PAPPA	Ssm	4	22	18.2%	cbioportal
20	SPTA1	Ssm	4	22	18.2%	cbioportal
21	SYNE2	Ssm	4	22	18.2%	cbioportal
22	TIAM1	Ssm	4	22	18.2%	cbioportal
23	TTK	Ssm	4	22	18.2%	cbioportal
25	USP34	Ssm	4	22	18.2%	cbioportal
28	ABCB5	Ssm	3	22	13.6%	cbioportal
26	ABCA7	Ssm	3	22	13.6%	cbioportal
27	ABCA8	Ssm	3	22	13.6%	cbioportal
29	ADAMTS18	Ssm	3	22	13.6%	cbioportal
30	ANK3	Ssm	3	22	13.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Stomach Adenocarcinoma (U Tokyo, Nat Genet 2014) stad_utokyoU Tokyo

30 cases with simple somatic mutation data · 30 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	10	30	33.3%	cbioportal
2	TTN	Ssm	8	30	26.7%	cbioportal
3	RHOA	Ssm	7	30	23.3%	cbioportal
4	ARID1A	Ssm	5	30	16.7%	cbioportal
5	CACNA1H	Ssm	4	30	13.3%	cbioportal
6	CDC27	Ssm	4	30	13.3%	cbioportal
7	CDH1	Ssm	4	30	13.3%	cbioportal
8	KIF2B	Ssm	4	30	13.3%	cbioportal
9	MUC16	Ssm	4	30	13.3%	cbioportal
11	SPTA1	Ssm	4	30	13.3%	cbioportal
10	MYT1L	Ssm	4	30	13.3%	cbioportal
14	CSMD1	Ssm	3	30	10%	cbioportal
26	STAB1	Ssm	3	30	10%	cbioportal
12	COL12A1	Ssm	3	30	10%	cbioportal
13	CRB1	Ssm	3	30	10%	cbioportal
27	SYNE1	Ssm	3	30	10%	cbioportal
28	TENM1	Ssm	3	30	10%	cbioportal
29	TLL1	Ssm	3	30	10%	cbioportal
30	TPRXL	Ssm	3	30	10%	cbioportal
25	SRRM4	Ssm	3	30	10%	cbioportal
24	RYR2	Ssm	3	30	10%	cbioportal
23	PLXNA4	Ssm	3	30	10%	cbioportal
22	NF1	Ssm	3	30	10%	cbioportal
21	NCKAP5	Ssm	3	30	10%	cbioportal
20	KCNT2	Ssm	3	30	10%	cbioportal
19	HEATR5B	Ssm	3	30	10%	cbioportal
18	GRM5	Ssm	3	30	10%	cbioportal
17	DYNC2H1	Ssm	3	30	10%	cbioportal
16	DMD	Ssm	3	30	10%	cbioportal
15	CYP7B1	Ssm	3	30	10%	cbioportal

Data updated 22 days agoSource updated 2026-01-13