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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
848 stopped studies mapped to Malignant Large Intestinal Neoplasm and descendants · 91% state a reason
Over the 848 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01767857 | A Phase III Study of Xilonix in Patients With Advanced Colorectal Cancer(XCITE) | Phase 3 | terminated | Jan 14, 2013 | Janssen Research & Development, LLC | The study crossed the prospective futility boundary of primary endpoint | Efficacy / futility |
| NCT03856255 | Polyp Measurement Device | N/A | terminated | Feb 27, 2019 | NYU Langone Health | Covid-19 restrictions with screening/surveillance colonoscopies | COVID-19 / pandemic |
| NCT03311750 | Anti-EGFR Therapy Rechallenge in Combination With Chemotherapy in Patients With Advanced…(A-REPEAT) | Phase 2 | terminated | Oct 17, 2017 | Hellenic Cooperative Oncology Group | It was considered that the recruitment of the remaining 10 patients required of the trial will not… | Enrollment / accrual |
| NCT02448810 | Phase 2a Study of BAX69 and 5-FU/Leucovorin or Panitumumab Versus Standard of Care in… | Phase 2 | terminated | May 20, 2015 | Baxalta now part of Shire | Based on overall benefit-risk assessment. | Other (stated, no rule matched) |
| NCT04464967 | Safety and Preliminary Efficacy of SNK01 in Combination With Trastuzumab or Cetuximab in… | Phase 1 / Phase 2 | withdrawn | Jul 9, 2020 | NKGen Biotech, Inc. | Trial not initiated | Other (stated, no rule matched) |
| NCT03158610 | Biological-guided Metronomic Chemotherapy as Maintenance Strategy in Metastatic… | Phase 2 / Phase 3 | terminated | May 18, 2017 | Ruijin Hospital | Difficult to enrollment patient | Enrollment / accrual |
| NCT02038699 | A First-in-man Phase I/II Study of Oral ONC201 in Patients With Advanced Cancer | Phase 1 / Phase 2 | withdrawn | Jan 16, 2014 | Jazz Pharmaceuticals | Protocol not activated. | Other (stated, no rule matched) |
| NCT02117466 | Image Guided Treatment Optimization With Cetuximab for Patients With Metastatic…(IMPACT-CRC) | Phase 1 / Phase 2 | terminated | Apr 21, 2014 | Amsterdam UMC, location VUmc | Primary endpoint could no longer be reached. | Other (stated, no rule matched) |
| NCT03137706 | Characterization of Mechanical Tissue Properties in Patients With Pancreatic, Liver, or… | — | terminated | May 3, 2017 | University of Southern California | Insufficient accrual | Enrollment / accrual |
| NCT03576963 | Guadecitabine and Nivolumab in Treating Refractory Metastatic Colorectal Cancer | Phase 1 / Phase 2 | withdrawn | Jul 5, 2018 | University of Southern California | No funding | Funding |
| NCT01280643 | Combination Chemotherapy and Cetuximab or Bevacizumab in Treating Patients With… | N/A | terminated | Jan 21, 2011 | Fox Chase Cancer Center | Slow accrual | Enrollment / accrual |
| NCT02550743 | BrUOG 302:BYL719, Capecitabine and Radiation for Rectal Cancer: A Brown University… | Phase 1 | terminated | Sep 15, 2015 | howard safran | lack of accural | Other (stated, no rule matched) |
| NCT03380689 | Phase I Study of Biweekly SIRB Regimen for Metastatic Colorectal Cancer(SIRB2) | Phase 1 | withdrawn | Dec 21, 2017 | Fujian Cancer Hospital | There is no fund to support it | Funding |
| NCT00005944 | Second-look Surgery With or Without Intraperitoneal Chemotherapy in Treating Patients… | Phase 2 | terminated | Mar 24, 2004 | UNICANCER | insuffisient recruitment | Enrollment / accrual |
| NCT01318161 | Epidural Versus Patient-controlled Analgesia for Reduction in Long-term Mortality…(EPICOL) | Phase 3 | terminated | Mar 18, 2011 | Örebro University, Sweden | Difficulty in recruiting | Enrollment / accrual |
| NCT02614157 | Lateral Lymph Node Dissection After Neoadjuvant Chemo-radiation in Advanced Low Rectal… | N/A | terminated | Nov 25, 2015 | West China Hospital | The enrollment was too low | Enrollment / accrual |
| NCT04664543 | Efficacy of Free Versus Low Residue Diet as Preparation for Screening Colonoscopy(CriLi) | N/A | terminated | Dec 11, 2020 | Parc Taulí Hospital Universitari | Organization and logistic problems due to COVID19 pandemy | COVID-19 / pandemic |
| NCT00578396 | Phase I Biomarker Study of Dietary Grape-derived Low Dose Resveratrol for Colon Cancer… | Phase 1 | withdrawn | Dec 21, 2007 | University of California, Irvine | Non applicable clinical trial | Other (stated, no rule matched) |
| NCT03149679 | The p53 Colorectal Cancer Trial | Phase 2 | terminated | May 11, 2017 | Haukeland University Hospital | The study was discontinued after the first pre-planned interim analysis due to insufficient… | Efficacy / futility |
| NCT03170115 | Induction Chemotherapy Plus Chemoradiotherapy With or Without Aspirin in High Risk Rectal…(ICAR) | Phase 2 | terminated | May 30, 2017 | Instituto Nacional de Cancer, Brazil | Aspirin added to chemoradiotherapy was safe but did not improve response to total neoadjuvant… | Other (stated, no rule matched) |
| NCT03563352 | Nutritional Preferences and Product Accessibility in Oral Nutritional Supplements in… | — | withdrawn | Jun 20, 2018 | University of Southern California | Zero accrual | Enrollment / accrual |
| NCT03257332 | Determining Early Development of Faecal Incontinence and Anorectal Muscle Function After…(EDFI-Cohort) | — | withdrawn | Aug 22, 2017 | Slagelse Hospital | Not possible to include participants | Other (stated, no rule matched) |
| NCT00023868 | Combination Chemotherapy With or Without Chemoembolization in Treating Patients With… | Phase 3 | terminated | Jun 17, 2003 | American College of Radiology Imaging Network | redesign | Other (stated, no rule matched) |
| NCT01097239 | Examining the Role of Transrectal High Intensity Focused Ultrasound (HIFU) in Rectal… | Phase 1 / Phase 2 | withdrawn | Apr 1, 2010 | Imperial College London | Failure to recruit. | Enrollment / accrual |
| NCT00986440 | Study of CS-7017 in Colorectal Cancer Patients Who Have Achieved Disease Control… | Phase 2 | terminated | Sep 30, 2009 | Daiichi Sankyo | Due to changes to the standard of care within the proposed market for CS-7017. | Other (stated, no rule matched) |
| NCT03974984 | Anesthesia and Immunological and Oxidative Stress in Relation to Abdominal Cancer Surgery(ANIMOX) | — | withdrawn | Jun 5, 2019 | University of Copenhagen | Not feasable due to logistics | Other (stated, no rule matched) |
| NCT02010567 | Neoadjuvant Chemoradiotherapy With CRLX-101 and Capecitabine for Rectal Cancer | Phase 1 / Phase 2 | terminated | Dec 12, 2013 | UNC Lineberger Comprehensive Cancer Center | The study was halted prematurely at the funding partner's request. | Funding |
| NCT02757391 | CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic… | Phase 1 | terminated | May 2, 2016 | M.D. Anderson Cancer Center | Study halted prematurely and will not resume; participants are no longer being examined or… | Other (stated, no rule matched) |
| NCT03724253 | [68Ga]-NeoBOMB1 Imaging in Patients With Malignancies Known to Overexpress Gastrin…(NeoFIND) | Phase 2 | terminated | Oct 30, 2018 | Advanced Accelerator Applications | Recruitment was stopped before the target sample size was achieved. | Enrollment / accrual |
| NCT04270461 | NKG2D-based CAR T-cells Immunotherapy for Patient With r/r NKG2DL+ Solid Tumors | Phase 1 | withdrawn | Feb 17, 2020 | Jiujiang University Affiliated Hospital | Study is withdrawn because of administrative reasons | Other (stated, no rule matched) |
| NCT00671645 | Preoperative Combined RadioChemo-Molecular Target Therapy With Capecitabine, Bevacizumab,… | Phase 2 | terminated | May 5, 2008 | Austrian Breast & Colorectal Cancer Study Group | reaching of step 1 (recruitment of 8 patients) per protocol -\> risk assessment -\> termination… | Safety / toxicity |
| NCT02012231 | Phase I/IIa Study to Evaluate the Safety, PK, PD, and Preliminary Efficacy of PLX8394 in… | Phase 1 | terminated | Dec 16, 2013 | Fore Biotherapeutics | not stated | Not stated |
| NCT03524274 | Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced… | Phase 2 | withdrawn | May 14, 2018 | Fuda Cancer Hospital, Guangzhou | No participants enrolled | Enrollment / accrual |
| NCT03549338 | Sym004 Versus Futuximab or Modotuximab in Patients With mCRC | Phase 2 | terminated | Jun 8, 2018 | Symphogen A/S | Study was terminated due to administrative reasons | Other (stated, no rule matched) |
| NCT03957096 | A Safety Study of SGN-CD47M in Patients With Solid Tumors | Phase 1 | terminated | May 21, 2019 | Seagen Inc. | Sponsor decision based on portfolio prioritization | Sponsor / business decision |
| NCT03029988 | An Evaluation of Tilmanocept by IV Injection Using SPECT/CT vs PET Imaging in Subjects… | Phase 1 | terminated | Jan 24, 2017 | Navidea Biopharmaceuticals | Lack of effect in Cohort 1 | Other (stated, no rule matched) |
| NCT01367275 | Irinotecan Plus Brivanib in Metastatic Colorectal Cancer (CRC) Enriched for Elevated… | Phase 2 | terminated | Jun 7, 2011 | M.D. Anderson Cancer Center | Sponsor closed study | Other (stated, no rule matched) |
| NCT02346955 | Study of CM-24 (MK-6018) Alone and In Combination With Pembrolizumab (MK-3475) in… | Phase 1 | terminated | Jan 27, 2015 | Famewave Ltd. | not stated | Not stated |
| NCT01302613 | Altered Chemotherapy Sequencing During Neoadjuvant Therapy for Patients With Stage II or… | Phase 1 / Phase 2 | withdrawn | Feb 24, 2011 | University of Texas Southwestern Medical Center | Drug shortage | Other (stated, no rule matched) |
| NCT03035253 | A Study of OMP-305B83 in Subjects With Metastatic Colorectal Cancer | Phase 1 | terminated | Jan 27, 2017 | OncoMed Pharmaceuticals, Inc. | not stated | Not stated |
| NCT03448874 | Seal-G MIST (Minimally Invasive Sealant/Spray Technology) System Safety Study [SEALAR…(SEALAR) | N/A | withdrawn | Feb 28, 2018 | Sealantis Ltd. | The company will design a new study | Sponsor / business decision |
| NCT01249443 | Paclitaxel and Carboplatin in Treating Patients With Metastatic or Recurrent Solid Tumors… | Phase 1 | terminated | Nov 29, 2010 | AIDS Malignancy Consortium | Inadequate accrual rate | Enrollment / accrual |
| NCT00740961 | Older Patients With Newly Diagnosed Breast Cancer or Colon Cancer | — | terminated | Aug 25, 2008 | Case Comprehensive Cancer Center | low accrual | Enrollment / accrual |
| NCT02453490 | Compare Efficacy and Safety of Raltitrexed-based and 5fu-based Neoadjuvant Chemotherapy… | Phase 3 | terminated | May 25, 2015 | Zhejiang University | difficultly recruiting | Enrollment / accrual |
| NCT02652702 | Study Comparing Circular Stapler-assisted Colostomy vs Hand-stitching Colostomy of…(STAPLER) | Phase 2 | terminated | Jan 12, 2016 | Zhejiang University | Not enough patients recruited | Enrollment / accrual |
| NCT00568425 | QOL & Functional Outcomes After Combined Modality Tx for Anal CA: Comparison of… | — | terminated | Dec 6, 2007 | Stanford University | Inadequate response to Scientific Review Committee. | Other (stated, no rule matched) |
| NCT04285008 | Randomized Controlled Study Comparing Colon Evaluation With The Pure-Vu System To A…(RESCue) | N/A | withdrawn | Feb 26, 2020 | Motus GI Medical Technologies Ltd | Sponsor has terminated study due to COVID-19 related concerns | COVID-19 / pandemic |
| NCT02205307 | A Study Assessing Perfusion Outcomes With PINPOINT® Near Infrared Fluorescence Imaging in…(PILLAR III) | N/A | terminated | Jul 31, 2014 | Novadaq Technologies ULC, now a part of Stryker | Slow recruitment | Enrollment / accrual |
| NCT03300609 | 5-FU Based Maintenance Therapy in RAS Wild Type Metastatic Colorectal Cancer After… | Phase 3 | terminated | Oct 3, 2017 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT03480152 | Messenger RNA (mRNA)-Based, Personalized Cancer Vaccine Against Neoantigens Expressed by… | Phase 1 / Phase 2 | terminated | Mar 29, 2018 | National Cancer Institute (NCI) | slow accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jun 29, 2021source: clinicaltrials