Clinical trial · Interventional
Epidural Versus Patient-controlled Analgesia for Reduction in Long-term Mortality Following Colorectal Cancer Surgery
Epidural or Patient-controlled Analgesia for Colorectal Cancer Surgery. Long-term Outcomes.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Difficulty in recruiting
Summary
Brief summary (as posted)
Colorectal cancer is one of the most common cancers in the industrialized world (12% of all cancers). In Sweden, 6000 new cases of colorectal cancer are reported each year, and almost half of these cases result in death. Several recently published retrospective studies show that regional anaesthesia (RA) can reduce cancer-related mortality following surgical treatment of colorectal, breast and prostate cancers and malignant melanoma. If these results are true, then the choice of perioperative pain management is as beneficial, or even better, than the current oncological therapies. This theory needs to be investigated in a prospective, randomized and controlled trail.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Other Complications | — | UNRESOLVED | — |
| Pain | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Morphine | Drug | — | UNRESOLVED |
| Ropivacaine + opioid epidurally | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Epidural anesthesia and analgesia
- interventionNames
- Drug: Ropivacaine + opioid epidurally
- type
- ACTIVE_COMPARATOR
- label
- Patient controlled analgesia
- interventionNames
- Drug: Morphine
Primary outcomes (1)
- measure
- Long-term (up to 5 yrs) all-cause mortality
- timeFrame
- 7 years from start of enrollment
- description
- Cancer specific as well as all-cause mortality would be recorded.
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * ASA status 1-3 * Age group 40-80 years old * Undergoing elective surgery for colorectal cancer Exclusion Criteria: * All contraindications to epidural analgesia * Chronic opiate medication/drug abuse * Allergy to morphine
References
Publications (0)
Data not yet available