Clinical trial · Interventional
Phase I Biomarker Study of Dietary Grape-derived Low Dose Resveratrol for Colon Cancer Prevention
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Non applicable clinical trial
Summary
Brief summary (as posted)
This study is designed to investigate the dietary influence of grapes in colon cancer prevention. A natural compound found in the skin of grapes, resveratrol, may protect against cancer by acting as an antioxidant (a chemical compound or substance that helps reduce damages due to oxygen). This compound is known to block colon cancer cell lines from growing in the laboratory. The purpose of this study is to determine the minimum amount of resveratrol-rich fresh red grapes needed to exhibit such signs of prevention.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| grapes | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Dose Level 1
- description
- 1 lb/day fresh red grapes
- interventionNames
- Dietary Supplement: grapes
- type
- ACTIVE_COMPARATOR
- label
- Dose Level 2
- description
- 2/3 lb/day fresh red grapes
- interventionNames
- Dietary Supplement: grapes
- type
- ACTIVE_COMPARATOR
- label
- Dose Level 3
- description
- 1/3 lb/day fresh red grapes
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * 18 years of age or older, male or female * Participants must sign informed consent for enrollment * Participants must have values for tests included in CBC, CMPAN and UA within normal range or no greater than 1.5x ULN or less than 0.75x LLN at prestudy to proceed to registration * Participants must have normal limited flexible sigmoidoscopic examination on Day 15 to proceed to re-registration * To receive Day 28 limited flexible sigmoidoscopy, participants must have taken \>80% of prescribed dose of red grapes (based on food diary review) Exclusion Criteria: * Pregnant or lactating (and/or elevated ßHCG at enrollment) * Known history of diabetes
References
Publications (0)
Data not yet available