NKG2D-based CAR T-cells Immunotherapy for Patient With r/r NKG2DL+ Solid Tumors

Inclusion criteria:

1. Men or women≥18 years old,
2. Patient with NKG2DL+ cell tumors confirmed by pathology and histology，
3. Fail or unwilling to receive first-line treatment,
4. Disease must be measurable according to the corresponding guidelines,
5. Main organs function normally and meet following requirements:

   Routine blood index（No Blood transfusion within 14 days） 1)HB≥90g/L; 2)ANC≥1.5×109/L; 3)PLT≥75×109/L； Serum biochemicals index 1) BIL \<1.5 upper normal limit (ULN); 2) ALT and AST\<2.5×ULN; In the case of liver metastasis, ALT and AST\<5×ULN; 3) Serum Cr≤1×ULN, endogenous creatinine clearance≥50ml/min (Cockcroft-Gault formula); 4) ECOG physical condition score: 0-2
6. Expected survival time ≥3 months,
7. Patient with adequate bone marrow reserve, hepatic and renal functions,
8. No other uncontrolled diseases such as lung, kidney and liver infection before enrollment,
9. Women of child-bearing age must undergo a negative pregnancy test (serum or urine) within 7 days prior to enrollment and voluntarily use appropriate methods of contraception during the observation period and within 8 weeks after the last dose; men should agree to contraception during the observation period and within 8 weeks of the last dose,
10. Patients voluntarily participated in this trial and sign the informed consent form,
11. Patients with compliance and expected to follow up the efficacy and adverse reactions as required by the protocol.

Exclusion criteria:

1. Pregnant or lactating women,
2. Patients who need to use systemic steroids at the same time,
3. Under following treatment conditions currently: 1) during the other anti- tumor clinical observation period within 14 days before blood collection; 2) patient has not recovered from acute side effects of the previous treatment;
4. Receive radiotherapy within 4 weeks before enrollment,
5. Patients who received any other cell therapy before,
6. Patients with unqualified T cell amplification efficiency,
7. Uncontrolled symptoms or other illnesses, including but not limited to infection, congestive heart failure, unstable angina, arrhythmia, psychosis,
8. Patients with severe acute allergic reactions,
9. Patients who have received other cell therapies,
10. Other serious conditions that may limit patient's participation in the study.

Detailed disease specific criteria exist and can be discussed with contacts listed below.