Study of Activated Cytokine-induced Killer Armed With Bispecific Antibody for Advanced Colorectal Cancer

Inclusion Criteria:

* 18-75 years old
* The patient is diagnosed as advanced colorectal cancer,MUC1 is positive
* There is at least one tumor should be measured,and length≥10mm of focus not at lymph node or length≥10mm of focus at lymph node
* The patient can't tolerate system(systemic chemotherapy/molecular targeted therapy) or local therapies
* If the patient received adjuvant chemotherapy after local treatment,the time should be more than 4 weeks after the end of chemotherapy, and disease progression or metastasis patients can also assigned into the group
* The time of surgical treatment≥ 3 months ;At the end of the intervention,radiotherapy and the end of the ablation time is more than 4 weeks
* The expected survival time ≥12 weeks
* The patient did not took any antitumor drugs within 4 weeks(any antitumor drugs, Chinese patent medicine including Delisheng injection,Kanglaite injection, Aidi injection
* No serious disease are conflicts with the solution(such as autoimmune disease,immunodeficiency,organ transplantation)
* Sign the informed consent

Exclusion Criteria:

* medium or above ascites
* Patient of second primary tumor or multiple primary cancer
* Patients of T cell lymphoma、myeloma,and patients are using immunosuppressant
* Systemic autoimmune diseases, allergic constitution or immunocompromised patients
* Patients of chronic diseases need immune stimulant or hormone therapy
* Patients of active bleeding or coagulant function abnormality（PT\>16s、APTT\>43s、TT\>21s、INR≥2）,and patients of bleeding tendency or are receiving thrombolysis and anticoagulation and antiplatelet therapy
* Women who is pregnant or during breast feeding or plan to pregnant in 2 years,and not willing to contraception during the test
* Patients with brain、dura mater metastases or history of psychogenic
* Gastrointestinal bleeding in the past six months or have clear gastrointestinal bleeding tendency,such as: patients of local active ulcerative lesions, defecate occult blood + + above shall not enter into group; defecate occult blood + depend on gastroscopy
* Patients with severe stomach/esophageal varices and need for intervention treatment
* Patients with abdominal fistula, gastrointestinal perforation or abdominal abscess within 4 weeks before the first treatment
* Positive for HIV antibody
* Patients who are allergic to computed tomography (CT) and magnetic resonance imaging (MRI) contrast agents at the same time, can't imaging assay
* Patients accepted any experimental drugs or pilot medical apparatus and instruments in the past 4 weeks of first treatment
* Other reasons the researchers think not suitable