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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,575 stopped studies mapped to Malignant Breast Neoplasm and descendants · 90% state a reason
Over the 1,575 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00607438 | A Phase II Study Of Abraxane and Nexavar in the First-Line Treatment of Locally Advanced… | Phase 2 | terminated | Feb 5, 2008 | Veeda Oncology | Low accrual | Enrollment / accrual |
| NCT00312637 | Using Magnetic Resonance Spectroscopy With MRI to Non-invasively Determine Breast Cancer… | N/A | withdrawn | Apr 10, 2006 | UNC Lineberger Comprehensive Cancer Center | Lack of funding. | Funding |
| NCT00343512 | Docetaxel Followed by Surgery in Treating Women With Stage II or Stage III Breast Cancer | Phase 2 | terminated | Jun 23, 2006 | Vanderbilt-Ingram Cancer Center | closed due to competing neoadjuvant studies for a small patient population | Other (stated, no rule matched) |
| NCT00083044 | Ductal Lavage in Assessing Women With Early Breast Cancer or at High Risk of Developing… | — | withdrawn | May 17, 2004 | Northwestern University | Funding ended and will not be renewed | Funding |
| NCT00241046 | Letrozole in the Treatment of 1st and 2nd Line Hormone Receptor Positive Breast Cancer:… | Phase 4 | terminated | Oct 18, 2005 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT01024114 | Study to Evaluate the Diagnostic Value of a Combined Molecular Breast Imaging/ Breast… | — | withdrawn | Dec 2, 2009 | Mayo Clinic | not stated | Not stated |
| NCT01305239 | A Survey Of Clinical Practice Of Adjuvant Treatment Of Breast Cancer Using Exemestane…(ETAPE) | — | terminated | Feb 28, 2011 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01045044 | Magnetic Resonance Imaging (MRI) of Tumor Response and Cognitive Impairment in Breast… | — | withdrawn | Jan 8, 2010 | Kettering Health Network | No participants enrolled | Enrollment / accrual |
| NCT01409226 | 3.0 Tesla Magnetic Resonance Imaging for Breast Cancer Detection in High Risk Women | N/A | withdrawn | Aug 4, 2011 | NYU Langone Health | Due to slow accrual | Enrollment / accrual |
| NCT01075607 | Lymph Fluid and Blood Collection for Identification of Novel Biomarkers | — | terminated | Feb 25, 2010 | Indiana University | Halted prematurely due to lack of funding. | Funding |
| NCT00657137 | APRiCOT-B: Study to Evaluate Apricoxib in Combination With Lapatinib and Capecitabine in…(APRiCOT-B) | Phase 2 | terminated | Apr 14, 2008 | Tragara Pharmaceuticals, Inc. | Slow accrual | Enrollment / accrual |
| NCT00739063 | Phase II Study of Erlotinib, an EGFR Inhibitor in Metastatic EGFR-positive 'Triple… | Phase 2 | terminated | Aug 21, 2008 | M.D. Anderson Cancer Center | Poor Accrual | Enrollment / accrual |
| NCT00453635 | Study With Docetaxel, Carboplatin and Herceptin Versus Vinorelbine and Herceptin in HER-2… | Phase 2 | terminated | Mar 29, 2007 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT00804544 | 99mTc-MIBI SPECT/CT in Breast Malignancy | N/A | terminated | Dec 9, 2008 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 4 patients have been enrolled into the pilot study. No complications reported. Another clinical… | Enrollment / accrual |
| NCT00955890 | Dexrazoxane as a Protective Agent in Anthracycline Treated Breast Cancer(cardioprotec) | Phase 2 | terminated | Aug 10, 2009 | Fudan University | Enrolled too slow | Enrollment / accrual |
| NCT01212887 | Treated Blood Cells, Cyclophosphamide, Fludarabine Phosphate, and Aldesleukin in Treating… | Phase 1 | terminated | Oct 1, 2010 | Cancer Research UK | due to safety concerns and lack of efficacy | Safety / toxicity |
| NCT01096381 | Potential Biomarkers for Bevacizumab-Induced High Blood Pressure in Patients With Solid… | — | terminated | Mar 31, 2010 | Vanderbilt-Ingram Cancer Center | funding withdrawn due to fellow's departure from VICC | Funding |
| NCT00502814 | 3-Dimensional Form and Soft Tissue Biomechanics of the Breast | — | terminated | Jul 18, 2007 | M.D. Anderson Cancer Center | Sample size too small for data analysis. | Other (stated, no rule matched) |
| NCT01254136 | Safety and Efficacy of INCB007839 With Trastuzumab and Vinorelbine in Patients With… | Phase 1 / Phase 2 | terminated | Dec 6, 2010 | Incyte Corporation | Incyte has suspended development of the compound. | Other (stated, no rule matched) |
| NCT01169870 | Genexol-PM Versus Paclitaxel in Anthracycline-pretreated Metastatic Breast Cancer Patients | Phase 2 | withdrawn | Jul 26, 2010 | National Cancer Center, Korea | withdrawn studies | Other (stated, no rule matched) |
| NCT00555867 | Patient's Anastrozole Compliance to Therapy Programme(PACT) | — | terminated | Nov 9, 2007 | AstraZeneca | High drop-out rate leads to the conclusion: not enough data will be available to perform proper… | Other (stated, no rule matched) |
| NCT01229605 | Cyclophosphamide and Docetaxel Every 3 Weeks as Neoadjuvant Therapy in Locally Advanced… | Phase 2 | withdrawn | Oct 28, 2010 | Tufts Medical Center | Study was not a good fit for the patient population seen at this hospital. | Other (stated, no rule matched) |
| NCT01100489 | Breast-Conserving Surgery Followed by Radiation Therapy With MRI-Detected Stage I or… | Phase 2 | withdrawn | Apr 9, 2010 | Case Comprehensive Cancer Center | No accrual | Enrollment / accrual |
| NCT00925405 | Breast Magnetic Resonance Imaging (MRI) Screening After Mantle Radiation Therapy | — | terminated | Jun 22, 2009 | M.D. Anderson Cancer Center | Low accrual | Enrollment / accrual |
| NCT00028483 | Monoclonal Antibody Therapy and Docetaxel in Treating Women With Metastatic or Recurrent… | Phase 2 | terminated | Jun 27, 2003 | Seagen Inc. | not stated | Not stated |
| NCT00679874 | Assessment of Cardiotoxicity After Chemotherapy for Breast Cancer by Cardio-vascular…(Cardiotox) | — | terminated | May 19, 2008 | University of Calgary | No subjects indentifiable | Other (stated, no rule matched) |
| NCT00023790 | Photodynamic Therapy in Treating Patients With Skin Cancer or Solid Tumors Metastatic to… | Phase 1 | terminated | Jan 27, 2003 | Case Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT00898781 | Study of Circulating Cancer Cells in Patients With Metastatic Breast, Ovarian, Colon, or… | — | terminated | May 12, 2009 | Mayo Clinic | Due to poor accrual | Enrollment / accrual |
| NCT00532285 | Primary Paclitaxel Plus Gemcitabine in Patients With Stage II and III Breast Cancer | Phase 2 | terminated | Sep 20, 2007 | National Cancer Center, Korea | terminated | Other (stated, no rule matched) |
| NCT00355745 | Safety and Efficacy of Using CBUS™ System for Ultrasound Breast Imaging Designed for… | N/A | terminated | Jul 25, 2006 | Helix Medical Systems | not stated | Not stated |
| NCT00942396 | Study to Compare the Diagnostic Accuracy of Nuance Full-Field Digital Mammography to… | Phase 3 | withdrawn | Jul 20, 2009 | Planmed Oy | FDA changed classification of device and no longer requires this type of clinical data | Other (stated, no rule matched) |
| NCT00101062 | Letrozole and Celecoxib in Treating Postmenopausal Women With Locally Advanced or… | Phase 2 | terminated | Jan 10, 2005 | University of Medicine and Dentistry of New Jersey | study drug unavailable | Other (stated, no rule matched) |
| NCT00790894 | Trial of Ixabepilone in Patients With HER-2 Negative Metastatic Breast Cancer (HIT)(HIT) | Phase 2 | terminated | Nov 14, 2008 | Hellenic Cooperative Oncology Group | The low accrual rate of the study (25% of the expected accrual rate) | Enrollment / accrual |
| NCT00193024 | Epirubicin and Docetaxel in the Treatment of Patients With Metastatic Breast Cancer | Phase 2 | terminated | Sep 19, 2005 | SCRI Development Innovations, LLC | not stated | Not stated |
| NCT00193102 | Thalidomide in Combination With Capecitabine in Patients With Metastatic Breast Cancer | Phase 2 | terminated | Sep 19, 2005 | SCRI Development Innovations, LLC | not stated | Not stated |
| NCT00216073 | Capecitabine, Oxaliplatin and Trastuzumab in Treating Patients With HER2 Positive… | Phase 2 | terminated | Sep 22, 2005 | Hoosier Cancer Research Network | Lack of patient accrual | Enrollment / accrual |
| NCT00522457 | Phase II Study With the Trifunctional Antibody Ertumaxomab to Treat Metastatic Breast… | Phase 2 | terminated | Aug 29, 2007 | Neovii Biotech | change in development plan, not due to safety concerns. | Safety / toxicity |
| NCT01232881 | Predicting Response and Toxicity in Patients Receiving Lonafarnib for Breast Cancer | — | terminated | Nov 2, 2010 | Hoosier Cancer Research Network | funding terminated | Funding |
| NCT00252811 | A Study of ZD1839 Effects on Cell Proliferation in Breast Cancer | Phase 2 | withdrawn | Nov 15, 2005 | AstraZeneca | not stated | Not stated |
| NCT00749255 | Collect Breast Cancer Patients' Digital Mammography Images With Corresponding Reports for… | — | terminated | Sep 9, 2008 | WellSpan Health | not enough personnel to conduct study at site | Other (stated, no rule matched) |
| NCT00888082 | Protection of Ovarian Function With Goserelin Acetate in Premenopausal Early Breast…(PROOF) | Phase 3 | withdrawn | Apr 24, 2009 | AstraZeneca | not stated | Not stated |
| NCT00847067 | Chronic Post Breast Surgery Pain | N/A | terminated | Feb 19, 2009 | Mayo Clinic | Funding not renewed | Funding |
| NCT00006261 | Allogeneic Transplantation Using Mini-Conditioning for Treatment of Stage IV Breast Cancer | Phase 2 | withdrawn | Apr 29, 2004 | Case Comprehensive Cancer Center | not stated | Not stated |
| NCT00630292 | Feasibility Study of Vessel Analysis for Noninvasive Diagnosis of Malignancy in Breast… | N/A | terminated | Mar 7, 2008 | University of North Carolina, Chapel Hill | Existing vessel analysis software could not be applied to breast MRI data. | Other (stated, no rule matched) |
| NCT00892268 | Acupuncture or Medication in Reducing Pain in Postmenopausal Women With Breast Cancer and… | Phase 2 | terminated | May 4, 2009 | University of Arizona | Poor accural | Other (stated, no rule matched) |
| NCT00171847 | Study of the Efficacy and Safety of Letrozole Combined With Trastuzumab in Patients With…(eLEcTRA) | Phase 4 | terminated | Sep 15, 2005 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT00036621 | A Randomized, Placebo-Controlled Trial of BMS-275291 Given Daily for 12 Months to Women… | Phase 2 | terminated | May 13, 2002 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00909558 | Safety and Effectiveness Study of Autologous Natural Killer and Natural Killer T Cells on… | Phase 1 | suspended | May 28, 2009 | Envita Medical Center, Inc. | not stated | Not stated |
| NCT00532454 | Evaluation of the Association Between CYP2D6 Genetic Polymorphisms and the Treatment… | Phase 2 | terminated | Sep 20, 2007 | National Cancer Center, Korea | planned to design a prospective study | Other (stated, no rule matched) |
| NCT00627627 | A Study to Evaluate the Antitumor Activity and Safety of IPI-504 in Patients With… | Phase 1 / Phase 2 | withdrawn | Mar 3, 2008 | MedImmune LLC | Redirect focus of the indication | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated May 11, 2012source: clinicaltrials