Clinical trial · Interventional
Dexrazoxane as a Protective Agent in Anthracycline Treated Breast Cancer
Randomized Phase II Trial Of Interventional Therapy Investigate Cardiac Protection of Dexrazoxane In Women With Breast Cancer Having Experienced Grade 1 Cardiotoxicity During Prior Anthracycline-based Chemotherapy.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Enrolled too slow
Summary
Brief summary (as posted)
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs, such as dexrazoxane, may protect normal cells from the side effects of chemotherapy. Monoclonal antibodies such as trastuzumab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. Radiation therapy uses high-energy x-rays to damage tumor cells. CTnT/cTnI/ANP/BNP were proved to be used as a biomarker of drug related cardiotoxicity. There are excellent correlations between the total cumulative dose of doxorubicin, the severity of the resulting cardiomyopathy, and the level of serum troponin-T.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexrazoxane hydrochloride | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- NO_INTERVENTION
- label
- control arm
- description
- anthracycline chemotherapy only
- type
- EXPERIMENTAL
- label
- low dose dexrazoxane group
- description
- anthracycline chemotherapy plus low dose dexrazoxane(10:1)
- interventionNames
- Drug: Dexrazoxane hydrochloride
- type
- EXPERIMENTAL
- label
- middle dose dexrazoxane group
- description
- anthracycline chemotherapy plus middle dose dexrazoxane(15:1)
- interventionNames
- Drug: Dexrazoxane hydrochloride
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: DISEASE CHARACTERISTICS: * Histologically confirmed primary infiltrating adenocarcinoma of the breast * Confirmed by core needle biopsy or incisional biopsy or surgery * Experienced grade 1 cardiac toxicity during prior anthracycline-based chemotherapy * At least 2 cycles same anthracycline based chemotherapy are needed Exclusion Criteria: * Accumulated dose of EPI ≥1000mg/m2,ADM≥550mg/m2 * With the following risk factors: Uncontrolled or severe cardiovascular disease (e.g., myocardial infarction within the past 6 months, congestive heart failure treated with medications, or uncontrolled hypertension); Prior or Concurrent radiation to heart * Pregnant or nursing * Other currently active malignancy except nonmelanoma skin cancer * Uncontrolled or severe bleeding,diarrhea,intestinal obstruction * Grade 2 or more Cardiac Toxicity (CTC AE3.0)
References
Publications (0)
Data not yet available