Clinical trial · Observational
Breast Magnetic Resonance Imaging (MRI) Screening After Mantle Radiation Therapy
Breast MRI Screening in High-Risk Women After Mantle Radiation Therapy for Lymphoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Low accrual
Summary
Brief summary (as posted)
Objectives: The objective of this single-arm, prospective study is to perform annual mammography and MRI breast cancer screening in women who underwent mantle-field irradiation between 1970-1995 at M. D. Anderson Cancer Center in order to compare the ability of MRI and standard mammography to identify breast cancer. In addition, we will determine whether the combination of breast MRI and mammography identifies smaller, earlier-stage tumors, which would lead to improved cure rates. We will also take the opportunity to determine the incidence and stage of breast cancer in this high-risk cohort.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Breast MRI | Procedure | — | UNRESOLVED |
| Mammogram | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Breast MRI Screening
- interventionNames
- Procedure: Breast MRI
- Procedure: Mammogram
Primary outcomes (1)
- measure
- Incidence of breast cancer detected with addition of breast MRI
- timeFrame
- Once a year
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria: 1. Female patients diagnosed with lymphoma prior to 1995 2. The radiation therapy must have been delivered at M.D. Anderson from start to finish with complete records of dose received 3. Patients must have received radiation therapy to the chest between the ages of 10 and 30 Exclusion Criteria: 1. Patients with claustrophobia 2. Obese patients (the equipment weight limit is 350 pounds and the maximum scanner bore diameter is 55 cm) 3. Patients with myocardial infarction within 6 months of study entry 4. Patients with unstable angina pectoris, uncontrolled congestive heart failure, or uncontrolled arrhythmias 5. Patients with aneurysm clips, pacemakers, or other implanted devices that are not MRI compatible 6. Pregnant patients 7. Patients with compromised renal function, with a calculated glomerular filtration rate (cGFR) less than 60 ml/min/1.73m2. 8. Patients who began their treatment outside of MD Anderson Cancer Center.
References
Publications (0)
Data not yet available