Monoclonal Antibody Therapy and Docetaxel in Treating Women With Metastatic or Recurrent Breast Cancer

DISEASE CHARACTERISTICS:

* Histologically confirmed metastatic or recurrent breast carcinoma

  * Unresectable disease
  * Previously treated with no more than 2 chemotherapy regimens for metastatic disease OR
  * Recurrent within 6 months of adjuvant chemotherapy
* Must have one of the following:

  * Measurable disease
  * Positive bone scan and elevation of serum tumor marker for adenocarcinoma

    * Serum levels must have increased over 2 consecutive measurements and exceed at least 2 times upper limit of normal
* Lewis-y antigen expression documented by immunohistochemistry
* No brain metastases that are uncontrolled or require active treatment (including steroids)
* Hormone receptor status:

  * Not specified

PATIENT CHARACTERISTICS:

Age:

* 18 and over

Sex:

* Female

Menopausal status:

* Not specified

Performance status:

* ECOG 0-2

Life expectancy:

* At least 3 months

Hematopoietic:

* Hemoglobin at least 10 g/dL
* Absolute neutrophil count at least 1,500/mm\^3
* Platelet count at least 100,000/mm\^3
* No bleeding diathesis

Hepatic:

* Bilirubin no greater than 1.5 mg/dL
* SGOT no greater than 2.5 times normal
* Alkaline phosphatase no greater than 2.5 times normal (unless documented bony metastasis present)
* Amylase/lipase less than 1.5 times normal
* Hepatitis B and C negative
* No hepatic failure

Renal:

* Creatinine no greater than 1.5 times upper limit of normal
* No renal failure

Cardiovascular:

* LVEF greater than 50% by echocardiogram or MUGA scan
* No congestive heart failure

Other:

* HIV negative
* No antibody present that detects monoclonal antibody BR96 in serum
* No peripheral neuropathy grade 2 or greater
* No dementia or altered mental status
* No other serious underlying medical condition that would preclude study participation
* No prior allergic reactions to recombinant human or murine proteins
* No uncontrolled peptic ulcer disease
* No active viral, bacterial, or systemic fungal infections
* No other primary malignancy except nonmelanoma skin cancer or carcinoma in situ of the cervix
* No serious nonmalignant disease
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* At least 8 weeks since prior therapeutic or diagnostic murine/humanized/human chimeric antibodies

Chemotherapy:

* See Disease Characteristics
* At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas, carboplatin, mitomycin, or anthracyclines)
* No prior cumulative anthracycline of 300 mg/m2 or more
* No concurrent antineoplastic agents

Endocrine therapy:

* See Disease Characteristics
* At least 4 weeks since prior hormonal therapy
* No concurrent hormonal therapy except estrogen replacement

Radiotherapy:

* At least 4 weeks since prior radiotherapy

Surgery:

* See Disease Characteristics

Other:

* No other concurrent experimental agents
* No concurrent immunosuppressive medications