Clinical trial · Interventional
Acupuncture or Medication in Reducing Pain in Postmenopausal Women With Breast Cancer and Joint Pain
Acupuncture for the Treatment of Aromatase Inhibitor Associated Joint Pain in Post-Menopausal Breast Cancer Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Poor accural
Summary
Brief summary (as posted)
RATIONALE: Acupuncture may reduce joint pain in postmenopausal women with breast cancer. It is not yet known whether acupuncture is more effective than standard therapy analgesics in decreasing joint pain caused by aromatase inhibitors. PURPOSE: This randomized phase II trial is studying acupuncture to see how well it works compared with medication in reducing pain in postmenopausal women with breast cancer and joint pain.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Menopausal Symptoms | — | UNRESOLVED | — |
| Pain | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| acupuncture therapy | Procedure | — | UNRESOLVED |
| pain therapy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Arm I
- description
- Patients undergo acupuncture for 20-30 minutes, on the appropriate pain points on the anterior portion of the body alternating with posterior portion of the body, thrice weekly for 2 weeks and then twice weekly for 3 weeks.
- interventionNames
- Procedure: acupuncture therapy
- type
- ACTIVE_COMPARATOR
- label
- Arm II
- description
- Patients receive standard-of-care analgesics (i.e., NSAIDs, narcotics, acetaminophen, or other) for 5 weeks. Patients not responding to analgesia may cross over to arm I.
- interventionNames
- Procedure: pain therapy
Primary outcomes (1)
- measure
- Improvement in pain, as defined by the WOMAC global score at 6 weeks
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Diagnosis of breast cancer * Concurrent therapy with anastrozole for the adjuvant treatment of breast cancer * Must have moderate or worse arthralgia, as defined by a baseline WOMAC pain scale score ≥ 48 * Patients with other underlying pain syndromes (e.g., osteoarthritis) are eligible, but the arthralgia must have worsened since starting anastrozole * Hormone receptor-positive disease PATIENT CHARACTERISTICS: * Post-menopausal status meeting the following criteria: * At least 12 months without spontaneous menstrual bleeding * History of bilateral salpingo-oophorectomy with or without hysterectomy * Age \> 55 with hysterectomy with or without oophorectomy * Age \< 55 with hysterectomy without oophorectomy or with unknown status, and serum FSH in post-menopausal range within the past 4 weeks * Not needle phobic * Patients with a contraindication to NSAIDs (i.e., prior gastrointestinal bleed secondary to NSAIDs or severe renal insufficiency) are eligible, but will be treated with alternative analgesics such as narcotics or acetaminophen PRIOR CONCURRENT THERAPY: * See Disease Characteristics * Concurrent chronic narcotics or NSAIDs allowed, but doses must be stable for ≥ the past month * Concurrent antidepressant medications allowed, but doses must be stable for ≥ the past 3 months * At least 6 months since prior acupuncture * No prior acupuncture for aromatase inhibitor-associated pain syndrome
References
Publications (0)
Data not yet available