KIT Exon 11 Mutation

CI-VAR-00000990Explore in graph →CIViC 66

Curated evidence

Evidence by cancer (18 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–18 of 18 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Gastrointestinal Stromal Tumor14
KIT Exon 11 Mutation	(prognostic)	Prognostic	B	Does Not Support N/A	3	accepted	EID53 There is no significant association between wildtype KIT or KIT mutations in exon 9 or 11 in survival among GIST patients. PMID 16551858 · Wardelmann et al., 2006 · Open in CIViC	civic
KIT Exon 11 Mutation	(diagnostic)	Diagnostic	B	Supports Positive	2	accepted	EID225 KIT mutation is associated with larger, more invasive tumors, greater pathologic histology and older patients compared to tumors with wildtype KIT. PMID 10485475 · Taniguchi et al., 1999 · Open in CIViC	civic
KIT Exon 11 Mutation	(prognostic)	Prognostic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Malignant Lung Neoplasm1
KIT Exon 11 Mutation	(prognostic)	Prognostic	B	Does Not Support N/A	2	accepted	EID334 KIT mutations detected in 5/60 patients showed no prognostic significance in patients with small cell lung cancer. PMID 15217946 · Boldrini et al., 2004 · Open in CIViC	civic

Melanoma3
KIT Exon 11 Mutation	Dasatinib	Predictive	C	Supports Resistance	—	submitted	EID4686 In a phase 2 clinical trial of 39 stage 3/4 chemotherapy-naive unresectable melanoma patients, a patient harboring a KIT exon 11 Deletion mutation was reported to have no response to dasatinib monothe… (full text at CIViC) PMID 21523734 · Kluger et al., 2011 · Open in CIViC	civic
KIT Exon 11 Mutation	Imatinib	Predictive	B	Supports Sensitivity Response	3	accepted	EID58 Melanoma patients with KIT mutation but not KIT amplification showed response to imatinib treatment in a small cohort of patients. PMID 23775962 · Hodi et al., 2013 · Open in CIViC	civic
KIT Exon 11 Mutation	Sunitinib	Predictive	C	Supports Sensitivity Response	3	accepted	EID1224 10 melanoma patients were evaluated after sunitinib treatment, among which 3 out of the 4 patients with KIT exon 11 mutations showed either complete or partial response. PMID 22261812 · Minor et al., 2012 · Open in CIViC	civic