PDGFRA D842V

CI-VAR-00000587Explore in graph →NP_006197.1:p.Asp842ValNM_006206.4:c.2525A>TClinVar 13543 CIViC 99 rs121908585

Curated evidence

Evidence by cancer (18 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–18 of 18 evidence items across 4 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Chronic Myeloid Leukemia, BCR-ABL1 Positive1
PDGFRA D842V	Bosutinib	Predictive	D	Supports Sensitivity Response	2	submitted	EID7514 In an in vitro kinase study, the recombinant PDGFRA D842V mutant kinase demonstrated sensitivity to bosutinib treatment at concentrations of 1μM and 10μM (activity %: 25 and 6) when compared to wild t… (full text at CIViC) PMID 19039322 · Remsing Rix et al., 2009 · Open in CIViC	civic
Gastrointestinal Stromal Tumor13
PDGFRA D842V	(diagnostic)	Diagnostic	B	Supports Negative	3	accepted	EID2 GIST tumors harboring PDGFRA D842V mutation are more likely to be benign than malignant. PMID 15146165 · Lasota et al., 2004 · Open in CIViC

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
13543	Conflicting classifications of pathogenicity	no assertion criteria provided	0	Gastrointestinal stromal tumor; Primary intracranial sarcoma, DICER1-mutant; Diffuse midline glioma, H3 K27M-mutant	somatic	4	Dec 01, 2006	clinvar

Malignant Neoplasm3
PDGFRA D842V	Imatinib	Predictive	D	Supports Resistance	2	accepted	EID2463 In an in vitro study of imatinib sensitivity, PDGFRA D842V was cloned into a plasmid by site-directed mutagenesis of PDGFRA WT cDNA. Chinese hamster ovary cells were transiently transfected with the p… (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC	civic
PDGFRA D842V	Imatinib Mesylate	Predictive	D	Supports Resistance	2	accepted	EID5346 In an in vitro study, Chinese hamster ovary cells expressing PDGFRA D842V mutation demonstrated reduced sensitivity to imatinib treatment (IC50=2,500 vs. IC50<100), compared to Chinese hamster ovary c… (full text at CIViC) PMID 18955458 · Heinrich et al., 2008 · Open in CIViC	civic
PDGFRA D842V	Sunitinib	Predictive	D	Supports Resistance	2	accepted	EID4060 In an in vitro study, Chinese hamster ovary cells expressing PDGFRA D842V mutation demonstrated reduced sensitivity to sunitinib treatment (IC50>1000 vs. IC50<100), compared to Chinese hamster ovary c… (full text at CIViC) PMID 18955458 · Heinrich et al., 2008 · Open in CIViC	civic

Myeloid/Lymphoid Neoplasms with Eosinophilia and Tyrosine Kinase Gene Fusions1
PDGFRA D842V AND FIP1L1::PDGFRA Fusion	Dasatinib + Imatinib + Masitinib + Nilotinib + Sorafenib + SunitinibSubstitutes	Predictive	D	Supports Resistance	3	submitted	EID13087 Ba/F3 cells expressing two clinically relevant, imatinib-resistant, mutant forms of FIP1L1-PDGFRA, namely T674I and D842V were tested for growth inhibition by 8 PDGFR-blocking TKIs. Cells expressing D… (full text at CIViC) PMID 24407160 · Sadovnik et al., 2014 · Open in CIViC	civic