PDGFRA I843DEL

CI-VAR-00002030Explore in graph →ENST00000257290.5:c.2527_2529delATCCIViC 101

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Gastrointestinal Stromal Tumor2
PDGFRA I843DEL	Crenolanib	Predictive	D	Supports Sensitivity Response	3	accepted	EID46 In CHO cells with the PDGFRA deletion I843 mutation that have shown imatinib sensitivity, crenolanib showed no significant difference from imatinib in kinase activity inhibition. PMID 22745105 · Heinrich et al., 2012 · Open in CIViC	civic
PDGFRA I843DEL	Imatinib	Predictive	D	Supports Sensitivity Response	2	accepted	EID1309 15/127 patients with KIT-WT metastatic gastrointestinal stromal tumors were tested for PDGFRA mutations. 6 GISTs harbored PDGFRA mutations. 1 patient had a deletion of I843. CHO cells expressing this … (full text at CIViC) PMID 14645423 · Heinrich et al., 2003 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.