MYC

MYC proto-oncogene, bHLH transcription factor

Identifier: CI-GENE-00015957
Entity page: /gene/MYC ↗
Edges: 36

Neighbours: 12 cancers24 variants
Drawn: 36 of 36 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
MYC associated with …ASSOCIATED_WITH3 of 3
→ associated with	Lung Squamous Cell Carcinomasubtype	supports	C	Lung Squamous Cell Carcinoma	1	Curated	civic	graph →
→ associated with	Lung Small Cell Carcinomasubtype	supports	D

MYC has variant …HAS_VARIANTderived24 of 24show fewer
→ has variant	Fusionfusion 3 accepted CIViC evidence items	—	—	not mapped	3	Curated	civic	graph →
→ has variant	Overexpressionexpression 3 accepted CIViC evidence items	—	—	Multiple Myeloma,Lung Squamous Cell Carcinoma,Lung Small Cell Carcinoma	3	Curated	civic	graph →
→ has variant	Amplificationamplification no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.1177C>T (p.Arg393Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.162G>C (p.Glu54Asp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.164T>C (p.Leu55Pro)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.176C>T (p.Ala59Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.17T>C (p.Val6Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.211C>A (p.Leu71Met)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.214C>T (p.Pro72Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.217_261del (p.Thr73_Pro87del)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.217A>G (p.Thr73Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.218C>A (p.Thr73Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.220C>G (p.Pro74Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.221C>T (p.Pro74Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.229T>C (p.Ser77Pro)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.302A>C (p.Asn101Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.482C>T (p.Ser161Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.490C>G (p.Leu164Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.62G>C (p.Ser21Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.770A>G (p.Glu257Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002467.6(MYC):c.77A>G (p.Asn26Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	p.S146LSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Translocationstructural no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

MYC has variant …HAS_VARIANTderived24 of 24show fewer

→ has variant

Fusionfusion

3 accepted CIViC evidence items

—

not mapped

Curated

MYC altered in cohorts of …ALTERED_INderived9 of 9
→ altered in cohorts of	Ovarian Serous Cystadenocarcinoma 455 / 603 cases (75 %) · ssm · TCGA-OV	—	—	Ovarian Serous Cystadenocarcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Uveal Melanoma 60 / 80 cases (75 %) · ssm · TCGA-UVM	—	—	Uveal Melanoma	1	Observed	gdc	graph →
→ altered in cohorts of	Esophageal Carcinoma 138 / 185 cases (75 %) · ssm · TCGA-ESCA	—	—	Esophageal Carcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 370 / 528 cases (70 %) · ssm · TCGA-HNSC	—	—	Head and Neck Squamous Cell Carcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 296 / 443 cases (67 %) · ssm · TCGA-STAD	—	—	Gastric Adenocarcinoma	1	Observed	gdc	graph →
→ altered in cohorts of	Osteosarcoma 65 / 145 cases (45 %) · ssm · TARGET-OS	—	—	Osteosarcoma	1	Observed	gdc	graph →
→ altered in cohorts of	Burkitt Lymphoma 45 / 263 cases (17 %) · ssm · CGCI-BLGSP	—	—	Burkitt Lymphoma	1	Observed	gdc	graph →
→ altered in cohorts of	Acute Myeloid Leukemia 27 / 200 cases (14 %) · ssm · TCGA-LAML	—	—	Acute Myeloid Leukemia	1	Observed	gdc	graph →
→ altered in cohorts of	B-Cell Non-Hodgkin Lymphoma 82 / 755 cases (11 %) · ssm · mbn_mdacc_2013 · largest of 3 cohorts	—	—	B-Cell Non-Hodgkin Lymphoma	3	Observed	cbioportal	graph →

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