MYC Fusion

CI-VAR-00001463Explore in graph →CIViC 5148

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
B-lymphoblastic Leukemia With MYC Rearrangement3unmapped disease
IGH::MYC Fusion	(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID12381 In this 2018 study, the authors analyzed tumor samples from 13 patients diagnosed with IG-MYC–positive neoplasms exhibiting a precursor B-cell phenotype. This entity is molecularly distinct from class… (full text at CIViC) PMID 30282799 · Wagener et al., 2018 · Open in CIViC	civic
IGH::MYC Fusion	(diagnostic)	Diagnostic	C	Supports Positive	3	accepted	EID12382 In this 2018 study, the authors described three rare adult cases of B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) exhibiting Burkitt lymphoma-like morphology driven by isolated IGH/MYC translocations—… (full text at CIViC) PMID 29112016 · Li et al., 2018 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.