KRAS

KRas proto-oncogene, GTPase

Identifier: CI-GENE-00007164
Entity page: /gene/KRAS ↗
Edges: 234

Neighbours: 32 cancers15 variants3 drugs
Drawn: 50 of 50 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
KRAS associated with …ASSOCIATED_WITH15 of 40show all (up to 200)
→ associated with	Malignant Colorectal Neoplasmsubtype 4 source records aggregated	supports	A	Malignant Colorectal Neoplasm	4	Curated	civic	graph →
→ associated with	Lung Non-Small Cell Carcinoma

KRAS targets …TARGETS3 of 3
← targets	Sotorasibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Salirasibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Adagrasibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

KRAS targets …TARGETS3 of 3

← targets

Sotorasibsmall_molecule

—

INHIBITOR

—

Curated

KRAS has variant …HAS_VARIANTderived15 of 168show all (up to 200)
→ has variant	Mutationother 49 accepted CIViC evidence items	—	—	Malignant Neoplasm,Melanoma,Hepatocellular Carcinoma+2	49	Curated	civic	graph →
→ has variant	G12DSNV 23 accepted CIViC evidence items	—	—	Melanoma,Hairy Cell Leukemia,Malignant Lung Neoplasm+2	23	Curated	civic	graph →
→ has variant	G12CSNV 18 accepted CIViC evidence items	—	—	Malignant Neoplasm,Solid Neoplasm,Malignant Lung Neoplasm+2	18	Curated	civic	graph →
→ has variant	G13DSNV 15 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm,Malignant Colorectal Neoplasm	15	Curated	civic	graph →
→ has variant	G12/G13 12 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Malignant Colorectal Neoplasm,Pancreatic Adenocarcinoma	12	Curated	civic	graph →
→ has variant	G12VSNV 12 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma+1	12	Curated	civic	graph →
→ has variant	Exon 2 MutationSNV 11 accepted CIViC evidence items	—	—	Malignant Pancreatic Neoplasm,Pancreatic Carcinoma,Malignant Colorectal Neoplasm+1	11	Curated	civic	graph →
→ has variant	G12 9 accepted CIViC evidence items	—	—	Acute Leukemia,Multiple Myeloma,Lung Non-Small Cell Carcinoma+1	9	Curated	civic	graph →
→ has variant	G12ASNV 9 accepted CIViC evidence items	—	—	Malignant Lung Neoplasm,Multiple Myeloma,Lung Adenocarcinoma+1	9	Curated	civic	graph →
→ has variant	G12SSNV 8 accepted CIViC evidence items	—	—	Malignant Lung Neoplasm,Multiple Myeloma,Malignant Colorectal Neoplasm	8	Curated	civic	graph →
→ has variant	G12RSNV 5 accepted CIViC evidence items	—	—	Malignant Pancreatic Neoplasm,Malignant Colorectal Neoplasm	5	Curated	civic	graph →
→ has variant	A146TSNV 4 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Colorectal Neoplasm	4	Curated	civic	graph →
→ has variant	Amplificationamplification 3 accepted CIViC evidence items	—	—	Melanoma,Cutaneous Melanoma,Malignant Endometrial Neoplasm	3	Curated	civic	graph →
→ has variant	Q61HSNV 3 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Colorectal Neoplasm	3	Curated	civic	graph →
→ has variant	Wildtypeother 3 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm,Pancreatic Ductal Adenocarcinoma	3	Curated	civic	graph →

KRAS altered in cohorts of …ALTERED_INderived23 of 23show fewer
→ altered in cohorts of	Testicular Germ Cell Tumor 255 / 263 cases (97 %) · ssm · TCGA-TGCT	—	—	Testicular Germ Cell Tumor	1	Observed	gdc	graph →
→ altered in cohorts of	Appendix Adenocarcinoma 161 / 273 cases (59 %) · ssm · appendiceal_msk_2022	—	—	Appendix Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Ampulla of Vater Carcinoma 86 / 160 cases (54 %) · ssm · ampca_bcm_2016	—	—	Ampulla of Vater Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colorectal Adenocarcinoma 495 / 1,134 cases (44 %) · ssm · crc_msk_2017 · largest of 14 cohorts	—	—	Colorectal Adenocarcinoma	14	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 3,096 / 7,237 cases (43 %) · ssm · crc_msk_2026 · largest of 2 cohorts	—	—	Rectal Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 183 / 429 cases (43 %) · ssm · coad_tcga_gdc · largest of 4 cohorts	—	—	Colon Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Pancreatic Adenocarcinoma 168 / 412 cases (41 %) · ssm · pancreas_ctdna_msk_2025 · largest of 10 cohorts	—	—	Pancreatic Adenocarcinoma	10	Observed	cbioportal	graph →
→ altered in cohorts of	Low-Grade Serous Ovarian Cancer 38 / 119 cases (32 %) · ssm · lgsoc_mapk_msk_2022	—	—	Low-Grade Serous Ovarian Cancer	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinomasubtype 787 / 2,653 cases (30 %) · ssm · luad_mskcc_2023_met_organotropism · largest of 13 cohorts	—	—	Lung Adenocarcinoma	13	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 67 / 247 cases (27 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Multiple Myelomahematologic_malignancy 227 / 961 cases (24 %) · ssm · MMRF-COMMPASS · largest of 2 cohorts	—	—	Multiple Myeloma	2	Observed	gdc	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinomasubtype 523 / 2,621 cases (20 %) · ssm · nsclc_ctdx_msk_2022 · largest of 6 cohorts	—	—	Lung Non-Small Cell Carcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 357 / 1,882 cases (19 %) · ssm · ucec_ancestry_cds_msk_2023 · largest of 8 cohorts	—	—	Endometrial Carcinoma	8	Observed	cbioportal	graph →
→ altered in cohorts of	Cholangiocarcinoma 76 / 417 cases (18 %) · ssm · chol_icgc_2017 · largest of 2 cohorts	—	—	Cholangiocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Non-Seminomatous Germ Cell Tumor 20 / 155 cases (13 %) · ssm · tgct_tcga	—	—	Non-Seminomatous Germ Cell Tumor	1	Observed	cbioportal	graph →
→ altered in cohorts of	Acute Lymphoblastic Leukemia 97 / 768 cases (13 %) · ssm · TARGET-ALL-P2	—	—	Acute Lymphoblastic Leukemia	1	Observed	gdc	graph →
→ altered in cohorts of	B Lymphoblastic Leukemia/Lymphoma 90 / 739 cases (12 %) · ssm · bll_target_gdc	—	—	B Lymphoblastic Leukemia/Lymphoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinomasubtype 152 / 1,370 cases (11 %) · ssm · hcc_msk_2024	—	—	Hepatocellular Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Intrahepatic Cholangiocarcinoma 39 / 412 cases (9.5 %) · ssm · ihch_msk_2021	—	—	Intrahepatic Cholangiocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 31 / 341 cases (9.1 %) · ssm · egc_msk_2017	—	—	Gastroesophageal Junction Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Acute Myeloid Leukemia 78 / 887 cases (8.8 %) · ssm · aml_stjude_2024 · largest of 2 cohorts	—	—	Acute Myeloid Leukemia	2	Observed	cbioportal	graph →
→ altered in cohorts of	Histiocytic and Dendritic Cell Neoplasm 102 / 1,270 cases (8.0 %) · ssm · hdcn_msk_2025	—	—	Histiocytic and Dendritic Cell Neoplasm	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 37 / 478 cases (7.7 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →

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