Variant · Snv
KRAS A146T
CI-VAR-00000059Explore in graph →NP_004976.2:p.Ala146ThrNM_004985.4:c.436G>AClinVar 197243 CIViC 906 rs121913527
Curated evidence
Evidence by cancer (12 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 2403644
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Lymphoma1 | ||||||||
| KRAS A146T | (predisposing) | Predisposing | D | Supports Pathogenic | 4 | submitted | EID7165A146T variant activates the transforming potential of the c-K-ras gene. DNA from the neutron-induced lymphoma containing the A146T varinat generated three independent nude mouse tumors containing addi… (full text at CIViC) PMID 2403644 · Sloan et al., 1990 · Open in CIViC | civic |
| Malignant Colorectal Neoplasm10 | ||||||||
| KRAS A146T | (oncogenic) | Oncogenic | D | Supports Oncogenicity | 1 | submitted | EID7167The variant was found in 6 of 220 primary colorectal cancer patients. Found in 2 Colorectal Cancer cell lines: HCC2998 and LS1034 Found in 1 AML cell line: ML-2 Mutations of this residue presumably al… (full text at CIViC) PMID 16969076 · | |
ClinVar
Clinical significance (1)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
- Source
- NCBI ClinVar (variant_summary)
- Dataset
- ClinVar variant_summary
- Version
- 2026-09-24
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- database
- License
- Public domain (US Government work, NCBI/NLM); acknowledgment requested
- Run
- ING-CLINVAR-20260929-000001
| Variation | Clinical significance | Review status | Stars | Conditions | Origin | Submitters | Last evaluated | Source |
|---|---|---|---|---|---|---|---|---|
| 197243 | Conflicting classifications of pathogenicity | criteria provided, conflicting classifications | 1 | OCULOECTODERMAL SYNDROME, SOMATIC; RASopathy; Encephalocraniocutaneous lipomatosis; Classic Hodgkin lymphoma; Cardiofaciocutaneous syndrome 2; Vascular malformation; Germinoma; Adenocarcinoma of the large intestine; KRAS-related disorder | germline/somatic | 10 | Feb 24, 2025 |