Variant
KRAS G12
CI-VAR-00001584Explore in graph →ClinVar 45122 CIViC 76 rs121913529
Curated evidence
Evidence by cancer (13 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 24571676
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Acute Leukemia1 | ||||||||
| KRAS G12 | (diagnostic) | Diagnostic | B | Supports Positive | 3 | accepted | EID8Children with early age leukaemia who had second hand smoke exposure are more likely to harbor KRAS mutation. PMID 24571676 · Andrade et al., 2014 · Open in CIViC | civic |
| Colorectal Adenocarcinoma2 | ||||||||
| KRAS G12 OR KRAS G13 OR KRAS Q61 | (prognostic) | Prognostic | B | Supports Poor Outcome | 3 | submitted | EID11056The Medical Research Council (MRC) COIN trial consisted of patients with histologically confirmed adenocarcinoma of the colon or rectum, inoperable metastatic or locoregional measurable disease, and w… (full text at CIViC) PMID 21641636 · Maughan et al., 2011 · Open in CIViC | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available