EGFR

epidermal growth factor receptor

Identifier: CI-GENE-00044375
Entity page: /gene/EGFR ↗
Edges: 4,204

Neighbours: 15 cancers15 variants32 drugs
Drawn: 60 of 62 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
EGFR associated with …ASSOCIATED_WITH15 of 32show all (up to 200)
→ associated with	Lung Non-Small Cell Carcinomasubtype 28 source records aggregated	supports	A	Lung Non-Small Cell Carcinoma	28	Curated	civic	graph →
→ associated with

EGFR targets …TARGETS32 of 32show fewer
← targets	Vandetanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Tarloxotinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	TAK-788small_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Rociletinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Rindopepimut	—	VACCINE ANTIGEN	—	1	Curated	chembl	graph →
← targets	Pyrotinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Poziotinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Panitumumabmonoclonal_antibody	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Osimertinib Mesylatesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Osimertinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Nimotuzumabmonoclonal_antibody	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Neratinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Necitumumabmonoclonal_antibody	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Naquotinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Mobocertinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Lazertinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Lapatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Icotinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Gefitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Firmonertinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Erlotinib Hydrochloridesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Erlotinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Duligotuzumabmonoclonal_antibody	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Dacomitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Dacomitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Cetuximabmonoclonal_antibody	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Canertinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Brigatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Aumolertinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Amivantamabmonoclonal_antibody	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Agerafenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Afatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

EGFR targets …TARGETS32 of 32show fewer

← targets

Vandetanibsmall_molecule

—

INHIBITOR

—

Curated

EGFR has variant …HAS_VARIANTderived15 of 4,134show all (up to 200)
→ has variant	L858RSNV 48 accepted CIViC evidence items	—	—	Malignant Neoplasm,Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma+2	48	Curated	civic	graph →
→ has variant	T790MSNV 37 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma+2	37	Curated	civic	graph →
→ has variant	Exon 19 Deletiondeletion 31 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	31	Curated	civic	graph →
→ has variant	Mutationother 17 accepted CIViC evidence items	—	—	Peritoneal Mesothelial Neoplasm,Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma+1	17	Curated	civic	graph →
→ has variant	Amplificationamplification 13 accepted CIViC evidence items	—	—	Glioblastoma,Barrett Adenocarcinoma,Cervical Squamous Cell Carcinoma+2	13	Curated	civic	graph →
→ has variant	Overexpressionexpression 9 accepted CIViC evidence items	—	—	Brain Glioblastoma,Esophageal Squamous Cell Carcinoma,Head and Neck Squamous Cell Carcinoma+1	9	Curated	civic	graph →
→ has variant	Exon 20 Insertioninsertion 7 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	7	Curated	civic	graph →
→ has variant	S768ISNV 6 accepted CIViC evidence items	—	—	Malignant Neoplasm,Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	6	Curated	civic	graph →
→ has variant	VIIIdeletion 6 accepted CIViC evidence items	—	—	Glioblastoma,Head and Neck Squamous Cell Carcinoma,High-Grade Glioma, NOS	6	Curated	civic	graph →
→ has variant	Expressionexpression 5 accepted CIViC evidence items	—	—	Chordoma,Lung Non-Small Cell Carcinoma,Malignant Colorectal Neoplasm	5	Curated	civic	graph →
→ has variant	G719SSNV 4 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Malignant Colorectal Neoplasm	4	Curated	civic	graph →
→ has variant	S492RSNV 4 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	4	Curated	civic	graph →
→ has variant	A763_Y764insFQEAinsertion 3 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	3	Curated	civic	graph →
→ has variant	A767_V769dupASVinsertion 3 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	3	Curated	civic	graph →
→ has variant	E746_A750deldeletion 3 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Minimally Invasive Lung Adenocarcinoma	3	Curated	civic	graph →

EGFR altered in cohorts of …ALTERED_INderived6 of 6
→ altered in cohorts of	Glioblastomasubtype 455 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →
→ altered in cohorts of	Lung Adenocarcinomasubtype 866 / 2,653 cases (33 %) · ssm · luad_mskcc_2023_met_organotropism · largest of 16 cohorts	—	—	Lung Adenocarcinoma	16	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinomasubtype 662 / 2,621 cases (25 %) · ssm · nsclc_ctdx_msk_2022 · largest of 5 cohorts	—	—	Lung Non-Small Cell Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 146 / 1,004 cases (15 %) · ssm · glioma_mskcc_2019 · largest of 10 cohorts	—	—	Diffuse Glioma	10	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 65 / 696 cases (9.3 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 27 / 527 cases (5.1 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →

Radial view

Every edge, grouped by relationship

Paths