DNMT1

DNA methyltransferase 1

Identifier: CI-GENE-00043699
Entity page: /gene/DNMT1 ↗
Edges: 22

Neighbours: 4 cancers16 variants2 drugs
Drawn: 22 of 22 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
DNMT1 associated with …ASSOCIATED_WITH2 of 2
→ associated with	Gastric Adenocarcinomasubtype	supports	B	Gastric Adenocarcinoma	1	Curated	civic	graph →
→ associated with	Malignant Ovarian Neoplasmcancer	supports	D

DNMT1 targets …TARGETS2 of 2
← targets	Decitabinesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Azacitidinesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

DNMT1 targets …TARGETS2 of 2

← targets

Decitabinesmall_molecule

—

INHIBITOR

—

Curated

DNMT1 has variant …HAS_VARIANTderived16 of 16show fewer
→ has variant	EXPRESSIONexpression 2 accepted CIViC evidence items	—	—	Malignant Ovarian Neoplasm,Gastric Adenocarcinoma	2	Curated	civic	graph →
→ has variant	NM_001130823.3(DNMT1):c.1044-9_1044-8deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001130823.3(DNMT1):c.1171-19C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001130823.3(DNMT1):c.1280+1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001130823.3(DNMT1):c.1399+56G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001130823.3(DNMT1):c.1399+5G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001130823.3(DNMT1):c.1645-1G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001130823.3(DNMT1):c.1650G>A (p.Thr550=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001130823.3(DNMT1):c.3280G>T (p.Gly1094Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001130823.3(DNMT1):c.3939C>T (p.Gly1313=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001130823.3(DNMT1):c.410C>G (p.Thr137Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001130823.3(DNMT1):c.769-21T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001130823.3(DNMT1):c.80G>A (p.Arg27Gln)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001130823.3(DNMT1):c.855C>T (p.Gly285=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001130823.3(DNMT1):c.890A>G (p.Lys297Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001130823.3(DNMT1):c.891+8C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

DNMT1 altered in cohorts of …ALTERED_INderived2 of 2
→ altered in cohorts of	Invasive Breast Carcinoma 33 / 527 cases (6.3 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 42 / 696 cases (6.0 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →

Radial view

Every edge, grouped by relationship

Paths