ABL1

ABL proto-oncogene 1, non-receptor tyrosine kinase

Identifier: CI-GENE-00000153
Entity page: /gene/ABL1 ↗
Edges: 176

Neighbours: 10 cancers15 variants11 drugs
Drawn: 36 of 36 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Edges

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
ABL1 associated with …ASSOCIATED_WITH15 of 18show all (up to 200)
→ associated with	Chronic Myeloid Leukemia, BCR-ABL1 Positivemolecular_subtype 4 source records aggregated	supports	A	Chronic Myeloid Leukemia, BCR-ABL1 Positive	4	Curated	civic	graph →
→ associated with

ABL1 targets …TARGETS11 of 11
← targets	Regorafenib Anhydroussmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Regorafenibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Rebastinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Ponatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Nilotinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Imatinib Mesylatesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Imatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Dasatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Bosutinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Bafetinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Asciminibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

ABL1 targets …TARGETS11 of 11

← targets

Regorafenib Anhydroussmall_molecule

—

INHIBITOR

—

Curated

ABL1 has variant …HAS_VARIANTderived15 of 146show all (up to 200)
→ has variant	Fusionfusion 334 accepted CIViC evidence items	—	—	Malignant Neoplasm,Acute Lymphoblastic Leukemia,Acute Myeloid Leukemia+2	334	Curated	civic	graph →
→ has variant	T315ISNV 28 accepted CIViC evidence items	—	—	Malignant Neoplasm,Acute Lymphoblastic Leukemia,Chronic Myeloid Leukemia, BCR-ABL1 Positive	28	Curated	civic	graph →
→ has variant	F317LSNV 21 accepted CIViC evidence items	—	—	Malignant Neoplasm,Chronic Myeloid Leukemia, BCR-ABL1 Positive	21	Curated	civic	graph →
→ has variant	E255KSNV 20 accepted CIViC evidence items	—	—	Acute Lymphoblastic Leukemia,Chronic Myeloid Leukemia, BCR-ABL1 Positive	20	Curated	civic	graph →
→ has variant	G250ESNV 17 accepted CIViC evidence items	—	—	Malignant Neoplasm,Chronic Myeloid Leukemia, BCR-ABL1 Positive	17	Curated	civic	graph →
→ has variant	F359VSNV 15 accepted CIViC evidence items	—	—	Chronic Myeloid Leukemia, BCR-ABL1 Positive	15	Curated	civic	graph →
→ has variant	M244VSNV 15 accepted CIViC evidence items	—	—	Malignant Neoplasm,Chronic Myeloid Leukemia, BCR-ABL1 Positive	15	Curated	civic	graph →
→ has variant	M351TSNV 15 accepted CIViC evidence items	—	—	Malignant Neoplasm,Chronic Myeloid Leukemia, BCR-ABL1 Positive	15	Curated	civic	graph →
→ has variant	Y253HSNV 14 accepted CIViC evidence items	—	—	Acute Lymphoblastic Leukemia,Chronic Myeloid Leukemia, BCR-ABL1 Positive	14	Curated	civic	graph →
→ has variant	Fusionfusion 13 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma,B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	13	Curated	civic	graph →
→ has variant	E255VSNV 11 accepted CIViC evidence items	—	—	Chronic Myeloid Leukemia, BCR-ABL1 Positive	11	Curated	civic	graph →
→ has variant	V299LSNV 11 accepted CIViC evidence items	—	—	Chronic Myeloid Leukemia, BCR-ABL1 Positive	11	Curated	civic	graph →
→ has variant	H396RSNV 10 accepted CIViC evidence items	—	—	Chronic Myeloid Leukemia, BCR-ABL1 Positive	10	Curated	civic	graph →
→ has variant	Q252HSNV 10 accepted CIViC evidence items	—	—	Malignant Neoplasm,Chronic Myeloid Leukemia, BCR-ABL1 Positive	10	Curated	civic	graph →
→ has variant	F359CSNV 9 accepted CIViC evidence items	—	—	Chronic Myeloid Leukemia, BCR-ABL1 Positive	9	Curated	civic	graph →

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