| Vismodegib studied in …STUDIED_INderived75 of 75show fewer |
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| → studied in | NCT02465060Phase 2 · active not recruiting Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial) · 75 trials list this drug (15 active) | — | — | Hematopoietic and Lymphoid Cell Neoplasm,Lymphoma,Malignant Solid Neoplasm+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06616623Phase 1 · suspended Vismodegib and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer · 75 trials list this drug (15 active) | — | — | Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00878163Phase 1 · active not recruiting GDC-0449 and Erlotinib Hydrochloride With or Without Gemcitabine Hydrochloride in Treating Patients With Metastatic Pancreatic Cancer or Solid Tumors That Cannot Be Removed by Surgery · 75 trials list this drug (15 active) | — | — | Adult Solid Neoplasm,Pancreatic Neoplasm,Pancreatic Carcinoma+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02523014Phase 2 · recruiting Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas · 75 trials list this drug (15 active) | — | — | Meningioma,Intracranial Meningioma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01267955Phase 2 · active not recruiting Vismodegib in Treating Patients With Advanced Chondrosarcomas · 75 trials list this drug (15 active) | — | — | Chondrosarcoma,Clear Cell Chondrosarcoma,Dedifferentiated Chondrosarcoma+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00887159Phase 2 · completed A Randomized Phase II Study of Cisplatin and Etoposide in Combination With Either Hedgehog Inhibitor GDC-0449 or IGF-1R MOAB IMC-A12 for Patients With Extensive Stage · 75 trials list this drug (15 active) | — | — | Lung Small Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05538091Phase 2 · recruiting Vismodegib Combined With Atezolizumab in Platinum Resistant Ovarian, Fallopian Tube, and Primary Peritoneal Cancer · 75 trials list this drug (15 active) | — | — | Platinum-Resistant Primary Peritoneal Carcinoma,Platinum-Resistant Fallopian Tube Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06357988Phase 2 · active not recruiting Testing GDC-0449 (Vismodegib) as Potentially Targeted Treatment in Cancers With Smoothened or Patched 1 Mutant Tumors (MATCH - Subprotocol T) · 75 trials list this drug (15 active) | — | — | Hematopoietic and Lymphatic System Neoplasm,Lymphoma,Malignant Solid Neoplasm+1 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00833417Phase 2 · completed A Study Evaluating the Efficacy and Safety of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) in Patients With Advanced Basal Cell Carcinoma · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00959647Phase 2 · completed A Study of Vismodegib (GDC-0449) in Patients Treated With Vismodegib in a Previous Genentech-sponsored Phase I or II Cancer Study · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma,Malignant Ovarian Neoplasm,Malignant Colorectal Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02667574Phase 2 · completed Study Evaluating the Interest of Vismodegib as Neo-adjuvant Treatment of Basal Cell Carcinoma (BCC) · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05651828early Phase 1 · recruiting Adaptive Therapy of Vismodegib in Advanced Basal Cell Carcinoma · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03297606Phase 2 · recruiting Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR) · 75 trials list this drug (15 active) | — | — | Solid Neoplasm,Multiple Myeloma,Non-Hodgkin Lymphoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03498521Phase 2 · completed A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site · 75 trials list this drug (15 active) | — | — | Malignant Neoplasm of Unknown Primary | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01878617Phase 2 · active not recruiting A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma · 75 trials list this drug (15 active) | — | — | Medulloblastoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05561634Phase 2 · recruiting Radiotherapy by Sonic Hedgehog Pathway Inhibitors in Basal Cell Carcinoma · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT04341181Phase 2 · recruiting ProTarget - A Danish Nationwide Clinical Trial on Targeted Cancer Treatment Based on Genomic Profiling · 75 trials list this drug (15 active) | — | — | Neoplasm,Malignant Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05463757recruiting Oral Hedgehog Inhibitors in the Treatment of Basal Cell Carcinoma in the Netherlands: a Prospective Registration Study · 75 trials list this drug (15 active) | — | — | Skin Neoplasm,Basal Cell Neoplasm,Carcinoma+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01064622Phase 2 · completed Gemcitabine Hydrochloride With or Without Vismodegib in Treating Patients With Recurrent or Metastatic Pancreatic Cancer · 75 trials list this drug (15 active) | — | — | Pancreatic Neoplasm,Pancreatic Carcinoma,Pancreatic Adenocarcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT06344052Phase 2 · recruiting To Assess the Safety and Efficacy of SP-002 with Vismodegib for the Treatment of Locally Advanced Basal Cell Carcinoma · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01774253Phase 2 · terminated Erivedge (Vismodegib) in the Treatment of Pediatric Patients With Refractory Pontine Glioma · 75 trials list this drug (15 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02091141Phase 2 · completed My Pathway: A Study Evaluating Herceptin/Perjeta, Tarceva, Zelboraf/Cotellic, Erivedge, Alecensa, and Tecentriq Treatment Targeted Against Certain Molecular Alterations in Participants With Advanced Solid Tumors · 75 trials list this drug (15 active) | — | — | Neoplasm,Solid Neoplasm,Malignant Bladder Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05159245Phase 2 · recruiting The Finnish National Study to Facilitate Patient Access to Targeted Anti-cancer Drugs · 75 trials list this drug (15 active) | — | — | Hematopoietic and Lymphoid Cell Neoplasm,Malignant Neoplasm,Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03878524Phase 1 · terminated Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial · 75 trials list this drug (15 active) | — | — | Hematopoietic and Lymphatic System Neoplasm,Hematopoietic and Lymphoid Cell Neoplasm,Malignant Solid Neoplasm+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02925234Phase 2 · recruiting The Drug Rediscovery Protocol (DRUP Trial) · 75 trials list this drug (15 active) | — | — | Neoplasm,Malignant Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT05238831early Phase 1 · withdrawn SMMART Adaptive Clinical Treatment (ACT) Trial · 75 trials list this drug (15 active) | — | — | Malignant Solid Neoplasm,Sarcoma,Breast Carcinoma+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02073838Phase 2 · completed Ribavirin and Hedgehog Inhibitor With or Without Decitabine in AML · 75 trials list this drug (15 active) | — | — | Acute Myeloid Leukemia | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03158389Phase 1/Phase 2 · completed NCT Neuro Master Match - N²M² (NOA-20) · 75 trials list this drug (15 active) | — | — | Adult Glioblastoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03035188Phase 2 · completed Neoadjuvant Vismodegib in Patients With Large and/or Recurrent Resectable Basal Cell Carcinoma · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02436408Phase 4 · completed VISmodegib for ORbital and Periocular Basal Cell Carcinoma · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03052478Phase 2 · completed Study of Vismodegib in Advanced Gastric Adenocarcinoma Patients With SMO Overexpression · 75 trials list this drug (15 active) | — | — | Gastric Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01835626Phase 2 · completed Phase II Study of Radiation Therapy and Vismodegib for Advanced Head/Neck Basal Cell Carcinoma · 75 trials list this drug (15 active) | — | — | Malignant Skin Neoplasm,Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02366312Phase 2 · completed A Phase 2, Single-center, Single-arm, Open Label Trial of Vismodegib in Patients With Keratocystic Odontogenic Tumors · 75 trials list this drug (15 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00957229Phase 2 · completed To Determine The Efficacy and Safety of GDC-0449 in Patients With Basal Cell Nevus Syndrome (BCNS) · 75 trials list this drug (15 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01556009Phase 2 · completed Trial Comparing the Effects of Intermittent Vismodegib vs. PDT in Patients With Multiple Basal Cell Carcinomas · 75 trials list this drug (15 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02371967completed A Study to Assess the Effectiveness and Safety of Vismodegib (Erivedge®) in Participants With Advanced Basal Cell Carcinoma (BCC) · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02956889Phase 2 · terminated To Assess The Efficacy And Safety Of Vismodegib And Radiotherapy In Advanced Basal Cell Carcinoma · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT03767439Phase 2 · withdrawn Nivolumab With Vismodegib in Patients With Basal Cell Nevus Syndrome · 75 trials list this drug (15 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02067104Phase 2 · terminated Vismodegib in Basal Cell Carcinomas (BCC) Chemoprevention · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01367665Phase 2 · completed STEVIE: A Study of Vismodegib in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01700049Phase 2 · completed Study Evaluating the Efficacy of Oral Vismodegib in Various Histologic Subtypes · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01601184Phase 1/Phase 2 · terminated Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Patients With Medulloblastomas With an Activation of the Sonic Hedgehog Pathway · 75 trials list this drug (15 active) | — | — | Medulloblastoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02674009completed Observational Study to Determine the Effectiveness and Safety of Vismodegib (Erivedge®) in Participants With Locally Advanced Basal Cell Carcinoma (laBCC) · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01537107Phase 1 · completed Sirolimus and Vismodegib in Treating Patients With Solid Tumors or Pancreatic Cancer That is Metastatic or Cannot Be Removed By Surgery · 75 trials list this drug (15 active) | — | — | Adult Solid Neoplasm,Malignant Pancreatic Neoplasm,Pancreatic Neoplasm+1 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02690948Phase 1/Phase 2 · completed Pembrolizumab With or Without Vismodegib in Treating Metastatic or Unresectable Basal Cell Skin Cancer · 75 trials list this drug (15 active) | — | — | Skin Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01163084Phase 1/Phase 2 · terminated Leuprolide Acetate or Goserelin Acetate With or Without Vismodegib Followed by Surgery in Treating Patients With Locally Advanced Prostate Cancer · 75 trials list this drug (15 active) | — | — | Prostate Adenocarcinoma,Malignant Prostate Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01154452Phase 1/Phase 2 · completed Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma · 75 trials list this drug (15 active) | — | — | Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor,Chondrosarcoma,Gastrointestinal Stromal Tumor+2 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02115828early Phase 1 · completed A Study of Vismodegib in Men With Metastatic CRPC With Accessible Metastatic Lesions for Tumor Biopsy · 75 trials list this drug (15 active) | — | — | Malignant Prostate Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02639117Phase 1 · completed Photodynamic Therapy and Vismodegib for Multiple Basal Cell Carcinomas · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01631331early Phase 1 · completed Vismodegib in Treating Patients With Basal Cell Carcinoma (BCC) · 75 trials list this drug (15 active) | — | — | Malignant Skin Neoplasm,Skin Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT02694224Phase 2 · unknown Addition of Vismodegib to Neoadjuvant Chemotherapy in Triple Negative Breast Cancer Patients · 75 trials list this drug (15 active) | — | — | Malignant Breast Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01815840Phase 2 · completed A Study of Two Vismodegib Regimens in Participants With Multiple Basal Cell Carcinomas · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00980343Phase 2 · completed GDC-0449 in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery · 75 trials list this drug (15 active) | — | — | Adult Giant Cell Glioblastoma,Adult Glioblastoma,Adult Brain Neoplasm+1 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01195415Phase 2 · completed Vismodegib and Gemcitabine Hydrochloride in Treating Patients With Advanced Pancreatic Cancer · 75 trials list this drug (15 active) | — | — | Malignant Pancreatic Neoplasm,Pancreatic Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00968981Phase 1 · completed A Study of Hedgehog Pathway Inhibitor GDC-0449 in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists · 75 trials list this drug (15 active) | — | — | Malignant Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00636610Phase 2 · completed A Study of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) With Concurrent Chemotherapy and Bevacizumab As First-Line Therapy for Metastatic Colorectal Cancer · 75 trials list this drug (15 active) | — | — | Malignant Colorectal Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00739661Phase 2 · completed A Study of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) As Maintenance Therapy in Patients With Ovarian Cancer in a Second or Third Complete Remission · 75 trials list this drug (15 active) | — | — | Malignant Ovarian Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01174264Phase 1/Phase 2 · completed Evaluation of Food Effect on Pharmacokinetics of Vismodegib · 75 trials list this drug (15 active) | — | — | Malignant Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01898598Phase 2 · terminated A Study of Vismodegib With Surgery in Participants With Previously Untreated Basal Cell Carcinoma · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01944943Phase 2 · terminated Phase II Study of Vismodegib in Patients With Refractory or Relapsed B-cell Lymphoma or Chronic Lymphocytic Leukemia · 75 trials list this drug (15 active) | — | — | Chronic Lymphocytic Leukemia,Primary Central Nervous System Lymphoma,Diffuse Large B-Cell Lymphoma+1 | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01546519Phase 1 · completed A Study of Vismodegib in Patients With Advanced Solid Malignancies Including Hepatocellular Carcinoma With Varying Degrees of Renal or Hepatic Function · 75 trials list this drug (15 active) | — | — | Malignant Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00939484Phase 2 · completed Vismodegib in Treating Patients With Recurrent or Refractory Medulloblastoma · 75 trials list this drug (15 active) | — | — | Adult Medulloblastoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00982592Phase 2 · completed Combination Chemotherapy With or Without Vismodegib in Treating Patients With Advanced Stomach Cancer or Gastroesophageal Junction Cancer · 75 trials list this drug (15 active) | — | — | Malignant Gastric Neoplasm,Gastric Adenocarcinoma,Gastroesophageal Junction Adenocarcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01239316Phase 2 · completed Vismodegib in Treating Younger Patients With Recurrent or Refractory Medulloblastoma · 75 trials list this drug (15 active) | — | — | Childhood Medulloblastoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01880437Phase 2 · terminated A Study of Vismodegib in Patients With Relapsed/Refractory Acute Myelogenous Leukemia and Relapsed Refractory High-Risk Myelodysplastic Syndrome · 75 trials list this drug (15 active) | — | — | Myelodysplastic Syndrome | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00607724Phase 1 · completed GDC-0449 in Treating Patients With Locally Advanced or Metastatic Solid Tumors · 75 trials list this drug (15 active) | — | — | Adult Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01160250approved for marketing A Study of Vismodegib (GDC-0449) in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01209143Phase 1 · completed A Study of Pharmacokinetic Drug Interaction Study of the Hedgehog Pathway Inhibitor GDC-0449 in Combination With Rosiglitazone or Combined Oral Contraceptive in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists · 75 trials list this drug (15 active) | — | — | Malignant Solid Neoplasm | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01071564Phase 1 · terminated RO4929097 and Vismodegib in Treating Patients With Breast Cancer That is Metastatic or Cannot Be Removed By Surgery · 75 trials list this drug (15 active) | — | — | Malignant Breast Neoplasm,Breast Carcinoma,Triple-Negative Breast Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01330173Phase 1 · completed Vismodegib After Stem Cell Transplant in Treating Patients With High-Risk First Remission or Relapsed Multiple Myeloma · 75 trials list this drug (15 active) | — | — | Multiple Myeloma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01543581Phase 2 · completed Vismodegib for Treatment of Basal Cell Carcinoma · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01201915Phase 2 · completed A Study Evaluating the Efficacy and Safety of Vismodegib (GDC-0449) in Operable Basal Cell Carcinoma · 75 trials list this drug (15 active) | — | — | Basal Cell Carcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT00822458Phase 1 · completed GDC-0449 in Treating Young Patients With Medulloblastoma That is Recurrent or Did Not Respond to Previous Treatment · 75 trials list this drug (15 active) | — | — | Childhood Medulloblastoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01096732Phase 2 · terminated Hedgehog Inhibition for Pancreatic Ductal Adenocarcinoma (PDAC) in the Preoperative Setting (HIPPoS) · 75 trials list this drug (15 active) | — | — | Pancreatic Ductal Adenocarcinoma | 1 | Observed | clinicaltrials | graph → |
| → studied in | NCT01713218early Phase 1 · unknown Effect on Tumor Perfusion of a Chemotherapy Combining Gemcitabine and Vismodegib Before Surgery in Pancreatic Cancer · 75 trials list this drug (15 active) | — | — | not mapped | 1 | Observed | clinicaltrials | graph → |