Vismodegib in Basal Cell Carcinomas (BCC) Chemoprevention

Inclusion Criteria:

* Signed and dated informed consent document indicating that the subject (or legally acceptable representative) has been informed of all pertinent aspects
* Comply with scheduled visits, treatment plan, laboratory tests, and other study procedures.
* At least 18 years of age at the time of informed consent.
* History of 3 or more biopsy confirmed BCCs in the preceding 2 years, calculated from 2 years prior to the screening visit.
* No active skin cancers.
* Women of reproductive potential must agree to use two forms of acceptable contraception
* Male subjects must agree to use condoms at all times, even after a vasectomy, during sexual intercourse with female partners of reproductive potential during treatment with vismodegib and for 2 months after the last dose to avoid exposing a pregnant partner and the unborn fetus to vismodegib.
* Male patients must agree not to donate sperm during the study and for 2 months after discontinuation of vismodegib
* Agreement not to donate blood or blood products during the study and for 7 months after the last dose.
* Ability to understand and the willingness to sign a written informed consent document in English

Exclusion Criteria:

* Women who are pregnant or lactating, or planning pregnancy while enrolled in the study or for 7 months after the last dose of the study drug.
* Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. Subjects with clinically stable chronic medical conditions including, but not limited to, controlled hypertension, diabetes mellitus type II, hypercholesterolemia, or osteoarthritis, will be allowed to enter the study.
* Inability or unwillingness to swallow capsules.
* Have a history of alcohol of substance abuse, unless in full remission for greater than 6 months prior to the screening visit (Day 0) when the consent form is signed.
* Known to be infected with human immunodeficiency virus (HIV), hepatitis B or hepatitis C viruses.
* Currently receiving vismodegib, biologics or chemotherapy
* Currently undergoing treatment with photodynamic therapy, topical chemotherapy agents including Imiquimod, fluorouracil
* Subjects who have Gorlins syndrome
* Subjects who have received any type of solid organ transplant
* Subjects taking immunosuppressive medications at the screening visit. (Day 0)
* Participation in other study using an investigational or experimental therapy or procedure within 4 weeks or 5 half-lives (whichever is longer) before the screening visit and/or during study participation. Subjects cannot participate in studies of other investigational or experimental therapies or procedures at any time during their participation in this study.
* Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the subject inappropriate for entry into this study.
* Subjects unable or unwilling to comply with the study visit schedule and requirements of the study
* Subjects unable to speak and read the English language
* A subject who, in the opinion of the sponsor-investigator will be uncooperative or unable to comply with study procedures.