Trametinib

Cutaneous Melanoma,Malignant Biliary Tract Neoplasm,Malignant Colorectal Neoplasm+3

← predicts response to

sensitivity

Curated

← predicts response to

BRAF V600ESNV

11 source records aggregated

sensitivity

Curated

Cutaneous Melanoma,Melanoma

← predicts response to

BRAF V600KSNV

7 source records aggregated

sensitivity

Curated

Malignant Colorectal Neoplasm,Melanoma

← predicts response to

BRAF V600

4 source records aggregated

sensitivity

Curated

← predicts response to

KRAS Mutationother

2 source records aggregated

sensitivity

Curated

← predicts response to

GNAQ Mutationother

sensitivity

Curated

← predicts response to

NRAS Mutationother

sensitivity

Curated

Pancreatic Adenocarcinoma

← predicts response to

KRAS G12/G13

resistance

Curated

Cholangiocarcinoma,Digestive System Neuroendocrine Tumor,Intrahepatic Cholangiocarcinoma

← predicts response to

BRAF V600ESNV

4 source records aggregated

sensitivity

Curated

← predicts response to

BRAF Fusionfusion

sensitivity

Curated

← predicts response to

BRAF Fusionfusion

sensitivity

Curated

Malignant Ovarian Serous Tumor

← predicts response to

NRAS Q61KSNV

sensitivity

Curated

← predicts response to

BRAF Fusionfusion

sensitivity

Curated

← predicts response to

GNA11 Mutationother

sensitivity

Curated

Trametinib targets …TARGETS2 of 2
→ targets	MAP2K1	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	MAP2K2	—	INHIBITOR	—	1	Curated	chembl	graph →

Trametinib targets …TARGETS2 of 2

→ targets

MAP2K1

—

INHIBITOR

—

Curated

→ targets

MAP2K2

—

INHIBITOR

—

Curated

Trametinib investigated for …INVESTIGATED_FOR67 of 67show fewer
→ investigated for	Low Grade Gliomasubtype	supports	A	Low Grade Glioma	1	Curated	civic	graph →
→ investigated for	Solid Neoplasmcancer_family	supports	A	Solid Neoplasm	1	Curated	civic	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	supports	A	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ investigated for	Cutaneous Melanomacancer	supports	A	Cutaneous Melanoma	1	Curated	civic	graph →
→ investigated for	Melanomacancer_family 14 source records aggregated	supports	B	Melanoma	14	Curated	civic	graph →
→ investigated for	Cutaneous Melanomacancer 3 source records aggregated	supports	B	Cutaneous Melanoma	3	Curated	civic	graph →
→ investigated for	Malignant Colorectal Neoplasmsubtype 2 source records aggregated	supports	B	Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype 2 source records aggregated	supports	B	Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →
→ investigated for	Uveal Melanomasubtype	supports	B	Uveal Melanoma	1	Curated	civic	graph →
→ investigated for	Malignant Neoplasmcancer_family	supports	B	Malignant Neoplasm	1	Curated	civic	graph →
→ investigated for	Malignant Biliary Tract Neoplasmsubtype	supports	B	Malignant Biliary Tract Neoplasm	1	Curated	civic	graph →
→ investigated for	Thyroid Gland Anaplastic Carcinomasubtype	supports	B	Thyroid Gland Anaplastic Carcinoma	1	Curated	civic	graph →
→ investigated for	Pancreatic Adenocarcinomasubtype	supports	B	Pancreatic Adenocarcinoma	1	Curated	civic	graph →
→ investigated for	Glioblastomasubtype	unknown	4	Glioblastoma	1	Curated	chembl	graph →
→ investigated for	Gliomasubtype	unknown	4	Glioma	1	Curated	chembl	graph →
→ investigated for	Lung Neoplasmcancer_family	unknown	4	Lung Neoplasm	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Melanomacancer_family	unknown	4	Melanoma	1	Curated	chembl	graph →
→ investigated for	Cutaneous Melanomacancer 5 source records aggregated	supports	C	Cutaneous Melanoma	5	Curated	civic	graph →
→ investigated for	Melanomacancer_family 5 source records aggregated	supports	C	Melanoma	5	Curated	civic	graph →
→ investigated for	Intrahepatic Cholangiocarcinomasubtype 2 source records aggregated	supports	C	Intrahepatic Cholangiocarcinoma	2	Curated	civic	graph →
→ investigated for	Malignant Ovarian Serous Tumorsubtype	supports	C	Malignant Ovarian Serous Tumor	1	Curated	civic	graph →
→ investigated for	Uveal Melanomasubtype	supports	C	Uveal Melanoma	1	Curated	civic	graph →
→ investigated for	Spindle Cell Sarcomasubtype	supports	C	Spindle Cell Sarcoma	1	Curated	civic	graph →
→ investigated for	Gangliogliomasubtype	supports	C	Ganglioglioma	1	Curated	civic	graph →
→ investigated for	Transitional Cell Carcinomahistology	supports	C	Transitional Cell Carcinoma	1	Curated	civic	graph →
→ investigated for	Malignant Pancreatic Neoplasmcancer	supports	C	Malignant Pancreatic Neoplasm	1	Curated	civic	graph →
→ investigated for	Cholangiocarcinomasubtype	supports	C	Cholangiocarcinoma	1	Curated	civic	graph →
→ investigated for	Digestive System Neuroendocrine Tumorsubtype	supports	C	Digestive System Neuroendocrine Tumor	1	Curated	civic	graph →
→ investigated for	Sarcomacancer_family	unknown	3	Sarcoma	1	Curated	chembl	graph →
→ investigated for	Thyroid Gland Neoplasmsubtype	unknown	3	Thyroid Gland Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype 5 source records aggregated	supports	D	Lung Non-Small Cell Carcinoma	5	Curated	civic	graph →
→ investigated for	Cutaneous Melanomacancer 4 source records aggregated	supports	D	Cutaneous Melanoma	4	Curated	civic	graph →
→ investigated for	Malignant Neoplasmcancer_family 4 source records aggregated	supports	D	Malignant Neoplasm	4	Curated	civic	graph →
→ investigated for	Melanomacancer_family 3 source records aggregated	supports	D	Melanoma	3	Curated	civic	graph →
→ investigated for	Uveal Melanomasubtype 2 source records aggregated	supports	D	Uveal Melanoma	2	Curated	civic	graph →
→ investigated for	Childhood Low Grade Gliomasubtype	supports	D	Childhood Low Grade Glioma	1	Curated	civic	graph →
→ investigated for	Childhood Pilocytic Astrocytomasubtype	supports	D	Childhood Pilocytic Astrocytoma	1	Curated	civic	graph →
→ investigated for	Malignant Colorectal Neoplasmsubtype	supports	D	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ investigated for	Uveal Melanomasubtype	unknown	2	Uveal Melanoma	1	Curated	chembl	graph →
→ investigated for	Thyroid Gland Anaplastic Carcinomasubtype	unknown	2	Thyroid Gland Anaplastic Carcinoma	1	Curated	chembl	graph →
→ investigated for	Craniopharyngiomacancer	unknown	2	Craniopharyngioma	1	Curated	chembl	graph →
→ investigated for	Colon Neoplasmsubtype	unknown	2	Colon Neoplasm	1	Curated	chembl	graph →
→ investigated for	Triple-Negative Breast Carcinomamolecular_subtype	unknown	2	Triple-Negative Breast Carcinoma	1	Curated	chembl	graph →
→ investigated for	Gastrointestinal Stromal Tumorsubtype	unknown	2	Gastrointestinal Stromal Tumor	1	Curated	chembl	graph →
→ investigated for	Carcinomacancer_family	unknown	2	Carcinoma	1	Curated	chembl	graph →
→ investigated for	Cholangiocarcinomasubtype	unknown	2	Cholangiocarcinoma	1	Curated	chembl	graph →
→ investigated for	Ameloblastomasubtype	unknown	2	Ameloblastoma	1	Curated	chembl	graph →
→ investigated for	Epithelioid Hemangioendotheliomasubtype	unknown	2	Epithelioid Hemangioendothelioma	1	Curated	chembl	graph →
→ investigated for	Breast Neoplasmcancer_family	unknown	2	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Cervical Neoplasmsubtype	unknown	2	Cervical Neoplasm	1	Curated	chembl	graph →
→ investigated for	Colorectal Neoplasmsubtype	unknown	2	Colorectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Multiple Myelomahematologic_malignancy	unknown	2	Multiple Myeloma	1	Curated	chembl	graph →
→ investigated for	Pancreatic Neoplasmsubtype	unknown	2	Pancreatic Neoplasm	1	Curated	chembl	graph →
→ investigated for	Thyroid Gland Follicular Carcinomacancer_family	unknown	2	Thyroid Gland Follicular Carcinoma	1	Curated	chembl	graph →
→ investigated for	Oral Cavity Neoplasmsubtype	unknown	2	Oral Cavity Neoplasm	1	Curated	chembl	graph →
→ investigated for	Hepatocellular Carcinomasubtype	unknown	2	Hepatocellular Carcinoma	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	2	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Prostate Neoplasmsubtype	unknown	2	Prostate Neoplasm	1	Curated	chembl	graph →
→ investigated for	Acute Myeloid Leukemiahematologic_malignancy	unknown	2	Acute Myeloid Leukemia	1	Curated	chembl	graph →
→ investigated for	Cutaneous Melanomacancer	supports	E	Cutaneous Melanoma	1	Curated	civic	graph →
→ investigated for	Liver Neoplasmsubtype	unknown	1	Liver Neoplasm	1	Curated	chembl	graph →
→ investigated for	Meningiomasubtype	unknown	1	Meningioma	1	Curated	chembl	graph →
→ investigated for	Gastric Neoplasmcancer_family	unknown	1	Gastric Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Adenocarcinomasubtype	unknown	1	Lung Adenocarcinoma	1	Curated	chembl	graph →
→ investigated for	Rectal Neoplasmsubtype	unknown	1	Rectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Leukemiacancer_family	unknown	1	Leukemia	1	Curated	chembl	graph →

Trametinib investigated for …INVESTIGATED_FOR67 of 67show fewer

→ investigated for

Low Grade Gliomasubtype

supports

Low Grade Glioma

Curated

→ investigated for

Solid Neoplasmcancer_family

supports

Solid Neoplasm

Curated

→ investigated for

supports

Curated

→ investigated for

supports

Curated

→ investigated for

Melanomacancer_family

14 source records aggregated

supports

Curated

→ investigated for

3 source records aggregated

supports

Curated

Malignant Colorectal Neoplasm

→ investigated for

Malignant Colorectal Neoplasmsubtype

2 source records aggregated

supports

Curated

→ investigated for

2 source records aggregated

supports

Curated

→ investigated for

Uveal Melanomasubtype

supports

Curated

→ investigated for

Malignant Neoplasmcancer_family

supports

Curated

Malignant Biliary Tract Neoplasm

→ investigated for

Malignant Biliary Tract Neoplasmsubtype

supports

Curated

Thyroid Gland Anaplastic Carcinoma

→ investigated for

Thyroid Gland Anaplastic Carcinomasubtype

supports

Curated

Pancreatic Adenocarcinoma

→ investigated for

Pancreatic Adenocarcinomasubtype

supports

Curated

→ investigated for

Glioblastomasubtype

unknown

Glioblastoma

Curated

→ investigated for

Gliomasubtype

unknown

Glioma

Curated

→ investigated for

Lung Neoplasmcancer_family

unknown

Lung Neoplasm

Curated

→ investigated for

Neoplasmcancer_family

unknown

Neoplasm

Curated

→ investigated for

Melanomacancer_family

unknown

Curated

→ investigated for

5 source records aggregated

supports

Curated

→ investigated for

Melanomacancer_family

5 source records aggregated

supports

Curated

Intrahepatic Cholangiocarcinoma

→ investigated for

Intrahepatic Cholangiocarcinomasubtype

2 source records aggregated

supports

Curated

Malignant Ovarian Serous Tumor

→ investigated for

Malignant Ovarian Serous Tumorsubtype

supports

Curated

→ investigated for

Uveal Melanomasubtype

supports

Curated

→ investigated for

Spindle Cell Sarcomasubtype

supports

Spindle Cell Sarcoma

Curated

→ investigated for

Gangliogliomasubtype

supports

Ganglioglioma

Curated

Transitional Cell Carcinoma

→ investigated for

Transitional Cell Carcinomahistology

supports

Curated

Malignant Pancreatic Neoplasm

→ investigated for

Malignant Pancreatic Neoplasmcancer

supports

Curated

→ investigated for

Cholangiocarcinomasubtype

supports

Cholangiocarcinoma

Curated

Digestive System Neuroendocrine Tumor

→ investigated for

Digestive System Neuroendocrine Tumorsubtype

supports

Curated

→ investigated for

Sarcomacancer_family

unknown

Sarcoma

Curated

→ investigated for

Thyroid Gland Neoplasmsubtype

unknown

Thyroid Gland Neoplasm

Curated

→ investigated for

5 source records aggregated

supports

Curated

→ investigated for

4 source records aggregated

supports

Curated

→ investigated for

Malignant Neoplasmcancer_family

4 source records aggregated

supports

Curated

→ investigated for

Melanomacancer_family

3 source records aggregated

supports

Curated

→ investigated for

Uveal Melanomasubtype

2 source records aggregated

supports

Curated

Childhood Low Grade Glioma

→ investigated for

Childhood Low Grade Gliomasubtype

supports

Curated

Childhood Pilocytic Astrocytoma

→ investigated for

Childhood Pilocytic Astrocytomasubtype

supports

Curated

Malignant Colorectal Neoplasm

→ investigated for

Malignant Colorectal Neoplasmsubtype

supports

Curated

→ investigated for

Uveal Melanomasubtype

unknown

Curated

Thyroid Gland Anaplastic Carcinoma

→ investigated for

Thyroid Gland Anaplastic Carcinomasubtype

unknown

Curated

→ investigated for

Craniopharyngiomacancer

unknown

Craniopharyngioma

Curated

→ investigated for

Colon Neoplasmsubtype

unknown

Colon Neoplasm

Curated

Triple-Negative Breast Carcinoma

→ investigated for

Triple-Negative Breast Carcinomamolecular_subtype

unknown

Curated

Gastrointestinal Stromal Tumor

→ investigated for

Gastrointestinal Stromal Tumorsubtype

unknown

Curated

→ investigated for

Carcinomacancer_family

unknown

Carcinoma

Curated

→ investigated for

Cholangiocarcinomasubtype

unknown

Cholangiocarcinoma

Curated

→ investigated for

Ameloblastomasubtype

unknown

Ameloblastoma

Curated

Epithelioid Hemangioendothelioma

→ investigated for

Epithelioid Hemangioendotheliomasubtype

unknown

Curated

→ investigated for

Breast Neoplasmcancer_family

unknown

Breast Neoplasm

Curated

→ investigated for

Cervical Neoplasmsubtype

unknown

Cervical Neoplasm

Curated

→ investigated for

Colorectal Neoplasmsubtype

unknown

Colorectal Neoplasm

Curated

→ investigated for

Multiple Myelomahematologic_malignancy

unknown

Multiple Myeloma

Curated

→ investigated for

Pancreatic Neoplasmsubtype

unknown

Pancreatic Neoplasm

Curated

Thyroid Gland Follicular Carcinoma

→ investigated for

Thyroid Gland Follicular Carcinomacancer_family

unknown

Curated

→ investigated for

Oral Cavity Neoplasmsubtype

unknown

Oral Cavity Neoplasm

Curated

→ investigated for

Hepatocellular Carcinomasubtype

unknown

Hepatocellular Carcinoma

Curated

→ investigated for

unknown

Curated

→ investigated for

Prostate Neoplasmsubtype

unknown

Prostate Neoplasm

Curated

→ investigated for

Acute Myeloid Leukemiahematologic_malignancy

unknown

Acute Myeloid Leukemia

Curated

→ investigated for

supports

Curated

→ investigated for

Liver Neoplasmsubtype

unknown

Liver Neoplasm

Curated

→ investigated for

Meningiomasubtype

unknown

Meningioma

Curated

→ investigated for

Gastric Neoplasmcancer_family

unknown

Gastric Neoplasm

Curated

→ investigated for

Lung Adenocarcinomasubtype

unknown

Lung Adenocarcinoma

Curated

→ investigated for

Rectal Neoplasmsubtype

unknown

Rectal Neoplasm

Curated

→ investigated for

Leukemiacancer_family

unknown

Leukemia

Curated

Trametinib investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 180show all (up to 200)
→ investigated in trials for	Melanomacancer_family 63 trials (15 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Melanoma	63	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasmcancer_family 36 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	36	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 23 trials (7 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	23	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasmcancer_family 21 trials (7 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	21	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Solid Neoplasm 14 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Solid Neoplasm	14	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colorectal Neoplasmsubtype 13 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	13	Observed	clinicaltrials	graph →
→ investigated in trials for	Multiple Myelomahematologic_malignancy 11 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Multiple Myeloma	11	Observed	clinicaltrials	graph →
→ investigated in trials for	Hematopoietic and Lymphoid Cell Neoplasm 8 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hematopoietic and Lymphoid Cell Neoplasm	8	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Thyroid Gland Neoplasmcancer 7 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Thyroid Gland Neoplasm	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Thyroid Gland Anaplastic Carcinomasubtype 7 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Thyroid Gland Anaplastic Carcinoma	7	Observed	clinicaltrials	graph →
→ investigated in trials for	Cutaneous Melanomacancer 6 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Cutaneous Melanoma	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Carcinoma 5 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Carcinoma	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Lymphoma 5 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoma	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Neoplasmcancer_family 5 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Anaplastic Astrocytoma 4 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Anaplastic Astrocytoma	4	Observed	clinicaltrials	graph →

Trametinib investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 180show all (up to 200)

→ investigated in trials for

Melanomacancer_family

63 trials (15 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Malignant Neoplasmcancer_family

36 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

23 trials (7 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Solid Neoplasmcancer_family

21 trials (7 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Solid Neoplasm

Observed

→ investigated in trials for

Malignant Solid Neoplasm

14 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Malignant Solid Neoplasm

Observed

Malignant Colorectal Neoplasm

→ investigated in trials for

Malignant Colorectal Neoplasmsubtype

13 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Multiple Myelomahematologic_malignancy

11 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Multiple Myeloma

Observed

Hematopoietic and Lymphoid Cell Neoplasm

→ investigated in trials for

8 trials (6 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Hematopoietic and Lymphoid Cell Neoplasm

Observed

Malignant Thyroid Gland Neoplasm

→ investigated in trials for

Malignant Thyroid Gland Neoplasmcancer

7 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

Thyroid Gland Anaplastic Carcinoma

→ investigated in trials for

Thyroid Gland Anaplastic Carcinomasubtype

7 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

6 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Observed

→ investigated in trials for

Colorectal Carcinoma

5 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Colorectal Carcinoma

Observed

→ investigated in trials for

Lymphoma

5 trials (5 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Lymphoma

Observed

→ investigated in trials for

Neoplasmcancer_family

5 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Neoplasm

Observed

→ investigated in trials for

Anaplastic Astrocytoma

4 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Anaplastic Astrocytoma

Observed

Hematopoietic and Lymphoid Cell Neoplasm,Lymphoma,Malignant Solid Neoplasm+2

Trametinib studied in …STUDIED_INderived10 of 224show all (up to 200)
→ studied in	NCT02465060Phase 2 · active not recruiting Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial) · 224 trials list this drug (69 active)	—	—	Hematopoietic and Lymphoid Cell Neoplasm,Lymphoma,Malignant Solid Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT04111458Phase 1 · active not recruiting A Study to Test Different Doses of BI 1701963 Alone and Combined With Trametinib in Patients With Different Types of Advanced Cancer (Solid Tumours With KRAS Mutation) · 224 trials list this drug (69 active)	—	—	Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02015117Phase 1 · active not recruiting Trametinib With or Without Whole Brain Radiation Therapy in Treating Patients With Brain Metastases · 224 trials list this drug (69 active)	—	—	Brain Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06475989Phase 3 · recruiting Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer · 224 trials list this drug (69 active)	—	—	Differentiated Thyroid Gland Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT07468071Phase 1/Phase 2 · recruiting Rollover Study for Participants Who Have Been Treated With and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments · 224 trials list this drug (69 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT03340506Phase 4 · recruiting Dabrafenib and/or Trametinib Rollover Study · 224 trials list this drug (69 active)	—	—	Solid Neoplasm,Melanoma,Lung Non-Small Cell Carcinoma+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT03899155Phase 2 · recruiting Pan Tumor Rollover Study · 224 trials list this drug (69 active)	—	—	Malignant Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04940052Phase 3 · active not recruiting Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Previously Treated Patients With Metastatic, Radio-active Iodine Refractory BRAF V600E Mutation Positive Differentiated Thyroid Cancer · 224 trials list this drug (69 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT04544111Phase 2 · active not recruiting PDR001 Combination Therapy for Radioiodine-Refractory Thyroid Cancer · 224 trials list this drug (69 active)	—	—	Thyroid Gland Follicular Carcinoma,Malignant Thyroid Gland Neoplasm,Thyroid Gland Oncocytic Neoplasm+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT02196181Phase 2 · active not recruiting Testing Two Different Treatment Schedules of Dabrafenib and Trametinib for Skin Cancer Which Has Spread · 224 trials list this drug (69 active)	—	—	Melanoma,Cutaneous Melanoma	1	Observed	clinicaltrials	graph →

Trametinib studied in …STUDIED_INderived10 of 224show all (up to 200)

→ studied in

NCT02465060Phase 2 · active not recruiting

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial) · 224 trials list this drug (69 active)

—

Observed

→ studied in

NCT04111458Phase 1 · active not recruiting

A Study to Test Different Doses of BI 1701963 Alone and Combined With Trametinib in Patients With Different Types of Advanced Cancer (Solid Tumours With KRAS Mutation) · 224 trials list this drug (69 active)

—

Solid Neoplasm

Observed

→ studied in

NCT02015117Phase 1 · active not recruiting

Trametinib With or Without Whole Brain Radiation Therapy in Treating Patients With Brain Metastases · 224 trials list this drug (69 active)

—

Brain Neoplasm

Observed

Differentiated Thyroid Gland Carcinoma

→ studied in

NCT06475989Phase 3 · recruiting

Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer · 224 trials list this drug (69 active)

—

Observed

→ studied in

NCT07468071Phase 1/Phase 2 · recruiting

Rollover Study for Participants Who Have Been Treated With and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments · 224 trials list this drug (69 active)

—

not mapped

Observed

Solid Neoplasm,Melanoma,Lung Non-Small Cell Carcinoma+1

→ studied in

NCT03340506Phase 4 · recruiting

Dabrafenib and/or Trametinib Rollover Study · 224 trials list this drug (69 active)

—

Observed

→ studied in

NCT03899155Phase 2 · recruiting

Pan Tumor Rollover Study · 224 trials list this drug (69 active)

—

Observed

→ studied in

NCT04940052Phase 3 · active not recruiting

Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Previously Treated Patients With Metastatic, Radio-active Iodine Refractory BRAF V600E Mutation Positive Differentiated Thyroid Cancer · 224 trials list this drug (69 active)

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not mapped

Observed

Thyroid Gland Follicular Carcinoma,Malignant Thyroid Gland Neoplasm,Thyroid Gland Oncocytic Neoplasm+2

→ studied in

NCT04544111Phase 2 · active not recruiting

PDR001 Combination Therapy for Radioiodine-Refractory Thyroid Cancer · 224 trials list this drug (69 active)

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Observed