Ibuprofen

small molecule

Identifier: CI-DRUG-00000291
Entity page: /drug/ibuprofen ↗
Edges: 69

Neighbours: 18 cancers2 genes10 trials14 approvals
Drawn: 44 of 44 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Ibuprofen approved for …APPROVED_FORderived14 of 14
→ approved for	FDA · US · 2026Efficacy supplement 2026-01-23 (see label) FDA (US) · approved · 2026-01-23 · Efficacy supplement 2026-01-23 (see label)	—	approved	not mapped	1	Regulatory	openfda	open ↗
→ approved for	FDA · US · 2023Efficacy supplement 2023-05-11 (see label) FDA (US) · approved · 2023-05-11 · Efficacy supplement 2023-05-11 (see label)	—

Ibuprofen targets …TARGETS2 of 2
→ targets	PTGS1	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	PTGS2	—	INHIBITOR	—	1	Curated	chembl	graph →

Ibuprofen targets …TARGETS2 of 2

→ targets

PTGS1

—

INHIBITOR

—

Curated

Ibuprofen investigated for …INVESTIGATED_FOR4 of 4
→ investigated for	Breast Neoplasmcancer_family	unknown	3	Breast Neoplasm	1	Curated	chembl	graph →
→ investigated for	Gliomasubtype	unknown	2	Glioma	1	Curated	chembl	graph →
→ investigated for	Kidney Neoplasmsubtype	unknown	2	Kidney Neoplasm	1	Curated	chembl	graph →
→ investigated for	Uveal Melanomasubtype	unknown	1	Uveal Melanoma	1	Curated	chembl	graph →

Ibuprofen investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 29show all (up to 200)
→ investigated in trials for	Malignant Neoplasm 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Acute Leukemia 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Acute Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	B Acute Lymphoblastic Leukemia 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	B Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Blastic Plasmacytoid Dendritic Cell Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Blastic Plasmacytoid Dendritic Cell Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Castration-Resistant Prostate Carcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Castration-Resistant Prostate Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Childhood Acute Lymphoblastic Leukemia 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Childhood Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Choroid Melanoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Choroid Melanoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Chronic Myeloid Leukemia, BCR-ABL1 Positive 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Chronic Myeloid Leukemia, BCR-ABL1 Positive	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Eye Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Eye Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Hairy Cell Leukemia 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hairy Cell Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Hematopoietic and Lymphoid Cell Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hematopoietic and Lymphoid Cell Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Hodgkin Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Hodgkin Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Kidney Neoplasmsubtype 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Kidney Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Breast Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colon Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colon Neoplasm	1	Observed	clinicaltrials	graph →

Ibuprofen studied in …STUDIED_INderived10 of 20show all (up to 200)
→ studied in	NCT05842044Phase 2 · recruiting NSAID Use After Robotic Partial Nephrectomy · 20 trials list this drug (2 active)	—	—	Kidney Neoplasm,Malignant Kidney Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT07682558Phase 3 · not yet recruiting Efficacy of Non-opioid Drugs in Addition to Opioid Therapy for Cancer Pain Management · 20 trials list this drug (2 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT04681105Phase 1 · completed Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological Malignancies · 20 trials list this drug (2 active)	—	—	Hematopoietic and Lymphoid Cell Neoplasm,Acute Leukemia,Hairy Cell Leukemia+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT03493945Phase 1/Phase 2 · completed Phase I/II Study of Immunotherapy Combination BN-Brachyury Vaccine, M7824, N-803 and Epacadostat (QuEST1) · 20 trials list this drug (2 active)	—	—	Solid Neoplasm,Prostate Neoplasm,Malignant Prostate Neoplasm+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT02330926Phase 3 · completed Multimodal Intervention for Cachexia in Advanced Cancer Patients Undergoing Chemotherapy · 20 trials list this drug (2 active)	—	—	Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05012098Phase 2 · completed Phase 2 Study of Bintrafusp Alfa in Recurrent/Metastatic Olfactory Neuroblastoma (BARON). · 20 trials list this drug (2 active)	—	—	Nasal Cavity Neoplasm,Olfactory Neuroblastoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04523623NA · withdrawn Pain Control Differences Between Oxycodone and Ibuprofen in Children With Isolated Forearm Injuries · 20 trials list this drug (2 active)	—	—	Childhood Acute Lymphoblastic Leukemia	1	Observed	clinicaltrials	graph →
→ studied in	NCT05782608NA · completed IV Ibuprofen vs Ketorolac in Post Operative Pain in Colorectal Cancer Surgeries in Obese Patient · 20 trials list this drug (2 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT03186638Phase 2 · completed Low-Dose Ibuprofen in Improving Cognitive Impairment in Patients With Cancer · 20 trials list this drug (2 active)	—	—	Malignant Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02351700Phase 4 · completed Analgesia Regimens Following Trans-sphenoidal Surgery for Pituitary Tumors · 20 trials list this drug (2 active)	—	—	Pituitary Gland Neoplasm	1	Observed	clinicaltrials	graph →

Radial view

Every edge, grouped by relationship

Paths