Encorafenib

small molecule

Identifier: CI-DRUG-00000211
Entity page: /drug/encorafenib ↗
Edges: 133

Neighbours: 21 cancers1 genes2 variants10 trials12 approvals
Drawn: 46 of 46 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Encorafenib approved for …APPROVED_FOR19 of 12
→ approved for	Lung Non-Small Cell Carcinomasubtype	supports	FDA ORIG	Lung Non-Small Cell Carcinoma	1	Regulatory	openfda	graph →
→ approved for	Malignant Colorectal Neoplasmsubtype	supports	FDA ORIG

Encorafenib predicts response to …PREDICTS_RESPONSE_TO4 of 4
← predicts response to	BRAF V600ESNV	sensitivity	A	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
← predicts response to	BRAF V600	sensitivity	A	Melanoma	1	Curated	civic	graph →
← predicts response to	BRAF V600ESNV 2 source records aggregated	sensitivity	B	Malignant Colorectal Neoplasm	2	Curated	civic	graph →
← predicts response to	BRAF V600 2 source records aggregated	sensitivity	B	Malignant Colorectal Neoplasm	2	Curated	civic	graph →

Encorafenib predicts response to …PREDICTS_RESPONSE_TO4 of 4

← predicts response to

BRAF V600ESNV

sensitivity

Malignant Colorectal Neoplasm

Curated

Encorafenib investigated for …INVESTIGATED_FOR12 of 12
→ investigated for	Malignant Colorectal Neoplasmsubtype	supports	A	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ investigated for	Melanomacancer_family	supports	A	Melanoma	1	Curated	civic	graph →
→ investigated for	Malignant Colorectal Neoplasmsubtype 4 source records aggregated	supports	B	Malignant Colorectal Neoplasm	4	Curated	civic	graph →
→ investigated for	Colorectal Neoplasmsubtype	unknown	4	Colorectal Neoplasm	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	4	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Melanomacancer_family	unknown	4	Melanoma	1	Curated	chembl	graph →
→ investigated for	Pancreatic Neoplasmsubtype	unknown	2	Pancreatic Neoplasm	1	Curated	chembl	graph →
→ investigated for	Hairy Cell Leukemiahematologic_malignancy	unknown	2	Hairy Cell Leukemia	1	Curated	chembl	graph →
→ investigated for	Multiple Myelomahematologic_malignancy	unknown	2	Multiple Myeloma	1	Curated	chembl	graph →
→ investigated for	Thyroid Gland Neoplasmsubtype	unknown	2	Thyroid Gland Neoplasm	1	Curated	chembl	graph →
→ investigated for	Lung Non-Small Cell Carcinomasubtype	unknown	2	Lung Non-Small Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Skin Neoplasmcancer_family	unknown	0.5	Skin Neoplasm	1	Curated	chembl	graph →

Encorafenib investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 36show all (up to 200)
→ investigated in trials for	Melanomacancer_family 26 trials (9 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Melanoma	26	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colorectal Neoplasmsubtype 15 trials (8 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colorectal Neoplasm	15	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 6 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	6	Observed	clinicaltrials	graph →
→ investigated in trials for	Cutaneous Melanoma 5 trials (4 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Cutaneous Melanoma	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 5 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	5	Observed	clinicaltrials	graph →
→ investigated in trials for	Colon Adenocarcinoma 4 trials (3 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colon Adenocarcinoma	4	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Neoplasmsubtype 3 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Colon Neoplasm 3 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Colon Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Rectal Adenocarcinoma 3 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Rectal Adenocarcinoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Brain Neoplasm 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Brain Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Adenocarcinoma 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Adenocarcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Colorectal Carcinoma 2 trials (2 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Colorectal Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Neoplasm 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Rectal Neoplasm 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Rectal Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Microsatellite Stable Colorectal Carcinoma 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Microsatellite Stable Colorectal Carcinoma	2	Observed	clinicaltrials	graph →

Encorafenib studied in …STUDIED_INderived10 of 68show all (up to 200)
→ studied in	NCT06102902Phase 1 · recruiting Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer · 68 trials list this drug (28 active)	—	—	Colorectal Adenocarcinoma,Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04511013Phase 2 · recruiting A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases · 68 trials list this drug (28 active)	—	—	Melanoma,Cutaneous Melanoma,Mucosal Melanoma+1	1	Observed	clinicaltrials	graph →
→ studied in	NCT05985954Phase 1 · recruiting Open-label Phase 1b Study of Ulixertinib and Cetuximab or Ulixertinib in Combination With Cetuximab and Encorafenib in Patients With Unresectable or Metastatic Colorectal Cancer Who Have Previously Received EGFR or BRAF-directed Therapy · 68 trials list this drug (28 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT06578559Phase 2 · active not recruiting Phase II Study of ctDNA-guided Encorafenib Plus Cetuximab Retreatment in Patients BRAF V600E Mutated mCRC · 68 trials list this drug (28 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT04657991Phase 3 · active not recruiting A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma · 68 trials list this drug (28 active)	—	—	Melanoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04526782Phase 2 · active not recruiting ENCOrafenib With Binimetinib in bRAF NSCLC · 68 trials list this drug (28 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04221438Phase 2 · terminated Testing Treatment With Encorafenib and Binimetinib Before Surgery for Melanoma With Lymph Node Involvement · 68 trials list this drug (28 active)	—	—	Cutaneous Melanoma,Melanoma of Unknown Primary	1	Observed	clinicaltrials	graph →
→ studied in	NCT05217446Phase 2 · active not recruiting A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer · 68 trials list this drug (28 active)	—	—	Malignant Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT03693170Phase 2 · completed Encorafenib, Binimetinib and Cetuximab in Subjects With Previously Untreated BRAF-mutant ColoRectal Cancer · 68 trials list this drug (28 active)	—	—	Colorectal Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT05308446Phase 2 · active not recruiting Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation · 68 trials list this drug (28 active)	—	—	Colon Adenocarcinoma,Malignant Colon Neoplasm,Malignant Rectal Neoplasm+1	1	Observed	clinicaltrials	graph →

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